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" Emerging evidence suggests that, in conjunction with achieving a hematologic

response and a cytogenetic response, achieving a molecular response to therapy

may correlate with improved progression-free survival in patients with Ph+ CML.

Intitative reverse-transcriptase polymerase chain reaction (Q-RT-PCR) is " The

best way to assess molecular response in patients with Ph+ CML.2 Q-RT-PCR

enables extremely low levels of Bcr-Abl RNA transcripts to be monitored over

time.Timely access to consistent and easily interpretable Q-RT-PCR results is

important for:

a.. Assessing whether a patient with Ph+ CML has achieved or is trending

toward a desired response to therapy2

b.. Helping to ensure that a patient’s treatment is optimized over time2

A group of international experts in Ph+ CML is currently working to establish a

uniform standard for performing Q-RT-PCR and reporting and interpreting the

results.2 These experts recommend that Q-RT-PCR be performed at least every 3

months to assess response to therapy.2

Look for more information on standardized PCR testing offered through CML

Alliance™.

************************************

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Lottie

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