Guest guest Posted August 7, 2009 Report Share Posted August 7, 2009 A warm welcome. , didn't your doc consider a switch to Tasigna, the third-line CML drug? I'm so terribly sorry to hear about your wife's death. Best from in San Francisco From: aardvarktype1a@... Date: Thu, 6 Aug 2009 22:42:14 +0000 Subject: [ ] Intro to ME! We hello all! Rotten place to meet isn't it? Think about it! This is like having tea and cake while watching a slow motion train wreck. And we are watching it happen to us. Oh, my name is george and I was diagnosed with CML in April 2006, and I was told about this group by Bobby who I met at the UofM Cancer Center. I know we've all had more than our share of cancer and cancer treatment, but I've had more than my share. You see my wife, Doreen, was diagnosed with breast cancer in in August of 2006. She was cancer free for one year before the cancer came back with a vengence. Sadly I lost my dearest Doreen this past January. Well enough said about that. I've been through some of the drugs that you are familiar with, Gleevec, which worked for about a year, then Sprycel that worked for about 8 months. At that point I was told by my doctor that my only options were a bone marrow transplant or a clinical trial, both available at the University of Michigan. I opted for the clinical trial keeping a transplant as my ace in the hole. The first trial I participated in was a Phase One trial of XL-228. Worked for only a few months. Now I've been in in the Ariad AP trial since the first of the year. And it isn't working as planned. It is doing something, but I'm not getting any big clinical splash. Well looking forward to conversing with you folks, take care. george rudzinski _________________________________________________________________ Get back to school stuff for them and cashback for you. http://www.bing.com/cashback?form=MSHYCB & publ=WLHMTAG & crea=TEXT_MSHYCB_BackToSch\ ool_Cashback_BTSCashback_1x1 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 7, 2009 Report Share Posted August 7, 2009 Hi , it is so good to have you post here. I have not run into you lately at the U of Mich., I am only going there once a month, and almost always on a Mon. I'll be there next on Aug. 31. You say Ariad is doing something, but not making a big clinical splash, but it is doing something....maybe you are just going to take a bit longer than some of us. Did Dr. Talpaz say why he did not try you on Tasigna? I believe he told me with the mutations I had, he did not think it would work. Please keep posting , I hope to see you there one of these days. Blessings, Bobby a (Bobby) Doyle Brecksville, Ohio, USA DX 05/1995 02/2000 - Gleevec Trial/OHSU 06/2002 - Gleevec/Trisenox Trial/OHSU 06/2003 - Gleevec/Zarnestra Trial/OHSU 04/2004 - Sprycel Trial/MDACC, CCR in 10 months #840 - Zavie's Zero Club 09/2006 - out of CCR 04/29/08 - XL228 Trial/ U.of Michigan 06/02/08 - CCR ( in 4 weeks) 02/13/09 - XL trial ended due to side effects 04/13/09 - New Trial, Ariad / U. of Mich./ Dr. Talpaz --- On Thu, 8/6/09, aardvarktype1a@... <aardvarktype1a@...> wrote: From: aardvarktype1a@... <aardvarktype1a@...> Subject: [ ] Intro to ME! Date: Thursday, August 6, 2009, 6:42 PM We hello all! Rotten place to meet isn't it? Think about it! This is like having tea and cake while watching a slow motion train wreck. And we are watching it happen to us. Oh, my name is george and I was diagnosed with CML in April 2006, and I was told about this group by Bobby who I met at the UofM Cancer Center. I know we've all had more than our share of cancer and cancer treatment, but I've had more than my share. You see my wife, Doreen, was diagnosed with breast cancer in in August of 2006. She was cancer free for one year before the cancer came back with a vengence. Sadly I lost my dearest Doreen this past January. Well enough said about that. I've been through some of the drugs that you are familiar with, Gleevec, which worked for about a year, then Sprycel that worked for about 8 months. At that point I was told by my doctor that my only options were a bone marrow transplant or a clinical trial, both available at the University of Michigan. I opted for the clinical trial keeping a transplant as my ace in the hole. The first trial I participated in was a Phase One trial of XL-228. Worked for only a few months. Now I've been in in the Ariad AP trial since the first of the year. And it isn't working as planned. It is doing something, but I'm not getting any big clinical splash. Well looking forward to conversing with you folks, take care. george rudzinski Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 7, 2009 Report Share Posted August 7, 2009 Hi !! I love how you write!! I'm sorry you are here and for what you have already been through!! I have to thank you and all the other warriors on this sight that keep plugging along. All of you who are bravely taking part in trials so if Gleevec stops working for me I will have options!! Thanks and Blessings, Jo-Dee --- On Thu, 8/6/09, aardvarktype1a@... <aardvarktype1a@...> wrote: From: aardvarktype1a@... <aardvarktype1a@...> Subject: [ ] Intro to ME! Date: Thursday, August 6, 2009, 10:42 PM We hello all! Rotten place to meet isn't it? Think about it! This is like having tea and cake while watching a slow motion train wreck. And we are watching it happen to us. Oh, my name is george and I was diagnosed with CML in April 2006, and I was told about this group by Bobby who I met at the UofM Cancer Center. I know we've all had more than our share of cancer and cancer treatment, but I've had more than my share. You see my wife, Doreen, was diagnosed with breast cancer in in August of 2006. She was cancer free for one year before the cancer came back with a vengence. Sadly I lost my dearest Doreen this past January. Well enough said about that. I've been through some of the drugs that you are familiar with, Gleevec, which worked for about a year, then Sprycel that worked for about 8 months. At that point I was told by my doctor that my only options were a bone marrow transplant or a clinical trial, both available at the University of Michigan. I opted for the clinical trial keeping a transplant as my ace in the hole. The first trial I participated in was a Phase One trial of XL-228. Worked for only a few months. Now I've been in in the Ariad AP trial since the first of the year. And it isn't working as planned. It is doing something, but I'm not getting any big clinical splash. Well looking forward to conversing with you folks, take care. george rudzinski Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2009 Report Share Posted August 14, 2009 Hello Jo-Dee, (Jo-Dee) I love how you write!! Why thankyou! I'm glad you were talking about my writing. A compliment like that could pose possible performance problems for a guy. I did have something profound to say here, well written I might add, but it has slipped my mind and is sadly lost in my neural morass. (Jo-Dee) I'm sorry you are here and for what you have already been through!! I'm not happy about being here either. I mean look at this place, all these sick people are depressing. (Jo-Dee) I have to thank you and all the other warriors on this sight that keep plugging along. All of you who are bravely taking part in trials so if Gleevec stops working for me I will have options!! Well I can't speak for others, but I don't see myself as being brave. I just didn't like the alternatives. As it was explained to me a transplant involved a one in four chance of dying. Even if the transplant is successful you have a one in three chance of having complications that are life altering. You see, from what I understand, the name of the game with a transplant is to induce " graft-host disease " where the donor marrow attacks the diseased marrow to keep it in check. And going without treatment would result in an extended dirt nap. Not a, ahem, viable option. I will admit I do like being at the cutting edge of medicine. At least this way I can make some sense out of this disease. I have a more optimistic outlook for drug trials than simply giving you options, though that is a bonus. I want to see a drug developed that wipes out the disease for you once and for all. Not to mention push the boundaries of using targeted drugs for other forms of cancer. george rudzinski Quote Link to comment Share on other sites More sharing options...
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