Tracey and Zavie, help me understand it, please!!!

[Guest guest]

I visited Dr. Druker on August 20th. He did additional PCR test as my last PCR

test on July 31st was incomplete (I'm very disappointed by my local onc). Today

Carolyn, Dr. Druker's assistant, posted FISH results on My Chart (see below).

Can you, please, help me to translate it from medical terms to " normal "

language?

Thank you in advance,

Lilia.

P.S. Back to our group discussion about frequency of PCR test. I asked about it

Dr. Druker and his recommendation was - every three months. I'll follow his

recommendation even if I would need to change local doctor every three months.

Unfortunately, my doc demands to perform PCR every six months despite my request

for three months interval.

CHROMOSOME REPORT Hem/Onc Blood: Full Study/FISH

** THIS IS AN AMENDED REPORT **

Supplemental indications: Chronic Myelogenous Leukemia FISH Results:

Normal Chromosome Results: See below

KARYOTYPE RESULTS: See below

IMPRESSIONS AND RECOMMENDATIONS:

Only three metaphase cells were found in all available material - they

appeared normal female.

Fluorescent in situ hybridization (FISH) was performed using the Abbott

BCR/ABL dual fusion and ASS probes. Of 200 interphase cells scored, 189

had the normal 2 green/ 2 red/ 2 aqua signal pattern; 11 cells had a 1

green/ 1 red/ 1 yellow/ 2 aqua signal pattern. Since these cells were not

deleted for ASS, the yellow signal is assumed to be artifact. No evidence

for BCR/ABL fusion.

[Note: Interphase FISH analysis is not intended to stand alone, but rather

to provide supplemental information to routine cytogenetic studies.]

Thank you very much for your referral. If you have any questions regarding

this report or future cytogenetic testing issues, please feel free to

contact us.

CYTOGENETIC ANALYSIS SUMMARY:

Number of Cells Analyzed: 3 Banding Level: <400

Number of Cells Karyotyped: 1 Banding Method: GTW

INTERPHASE FISH ANALYSIS SUMMARY:

Cells Scored: 200 Probe(s): Abbott BCR (22q11.2) (SG) / ABL (9q34)

(SO) + ASS (9q34) SA)

This test was developed and its performance characteristics determined by

the OHSU Cytogenetics Laboratory as required by the CLIA '88 regulations.

It has not been cleared or approved for specific uses by the U.S. Food and

Drug Administration.

Preliminary report date: FISH: 8/24/2009 Chromosomes: 8/31/2009

**Amended for typographical error – does not change interpretation**

The clinical interpretation was made by the clinical geneticist.

Rendering Diagnostician: Robb Moses MD, ABMG, FACMG

Clinical Geneticist

Electronically Signed 09/02/2009

Rendering Diagnostician: Olson PhD, ABMG, FACMG

Clinical Cytogeneticist

Electronically Signed 09/02/2009