Guest guest Posted October 5, 2009 Report Share Posted October 5, 2009 Hi Jo-Dee, The question you really want asked is: what is the sensitivity of the PCR test that is done at this lab? It is possible that the sensitivity could be +or- 0.001. This would mean that there is no difference between a value of 0.003 and 0.004. I don't believe that any of the CML experts would even consider a change in therapy until there is a full 1 log change in results. If you are nervous about these results, I would ask to have the PCR done again right away and then every 3 months afterwards. Zavie Zavie (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 3.8 log reduction Aug/09 e-mail: zmiller@... Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 ID: zaviem _____ From: [mailto: ] On Behalf Of Jo-Dee McKibben Sent: October 5, 2009 12:37 PM Subject: [ ] Possible Relapse Good Afternoon. I have a question for those of you that were on Gleevec and everything was going well. My last BCR-ABL test showed a tiny increase from .003 to .004. Instead of waiting 6 months to run the test again, Dr. is doing it in 3 months. I know I have been really busy lately but I have been napping on my lunch hour for about the last month or so on and off. This weekend I was so bone tired I could hardly put one foot in front of the other. I have my blood drawn on Wednesday. When the Gleevec started to not work anymore, what were your syptoms? Blessings, Jo-Dee Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2009 Report Share Posted October 5, 2009 What does a 1 full log change mean? thanks, Jo-Dee From: Zavie <zmiller@...> Subject: RE: [ ] Possible Relapse Date: Monday, October 5, 2009, 6:15 PM Hi Jo-Dee, The question you really want asked is: what is the sensitivity of the PCR test that is done at this lab? It is possible that the sensitivity could be +or- 0.001. This would mean that there is no difference between a value of 0.003 and 0.004. I don't believe that any of the CML experts would even consider a change in therapy until there is a full 1 log change in results. If you are nervous about these results, I would ask to have the PCR done again right away and then every 3 months afterwards. Zavie Zavie (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 3.8 log reduction Aug/09 e-mail: zmillersympatico (DOT) ca Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 ID: zaviem _____ From: groups (DOT) com [mailto:groups (DOT) com] On Behalf Of Jo-Dee McKibben Sent: October 5, 2009 12:37 PM groups (DOT) com Subject: [ ] Possible Relapse Good Afternoon. I have a question for those of you that were on Gleevec and everything was going well. My last BCR-ABL test showed a tiny increase from .003 to .004. Instead of waiting 6 months to run the test again, Dr. is doing it in 3 months. I know I have been really busy lately but I have been napping on my lunch hour for about the last month or so on and off. This weekend I was so bone tired I could hardly put one foot in front of the other. I have my blood drawn on Wednesday. When the Gleevec started to not work anymore, what were your syptoms? Blessings, Jo-Dee Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2009 Report Share Posted October 5, 2009 Hi again, A log is a mathematical term. For our situation it means a 10 fold change. So, if we start with a number like 0.003, then a value of 0.03 would be 10 times bigger and we would say that was a 1 log increase in value. Going from 0.003 to 0.0003 would be a 1 log decrease. So, going from 0.003 to 0.004 is a very, very small increase. Zavie Zavie (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 3.8 log reduction Aug/09 e-mail: zmiller@... Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 ID: zaviem _____ From: [mailto: ] On Behalf Of Jo-Dee McKibben Sent: October 5, 2009 2:20 PM Subject: RE: [ ] Possible Relapse What does a 1 full log change mean? thanks, Jo-Dee From: Zavie <zmillersympatico (DOT) <mailto:zmiller%40sympatico.ca> ca> Subject: RE: [ ] Possible Relapse groups (DOT) <mailto:%40> com Date: Monday, October 5, 2009, 6:15 PM Hi Jo-Dee, The question you really want asked is: what is the sensitivity of the PCR test that is done at this lab? It is possible that the sensitivity could be +or- 0.001. This would mean that there is no difference between a value of 0.003 and 0.004. I don't believe that any of the CML experts would even consider a change in therapy until there is a full 1 log change in results. If you are nervous about these results, I would ask to have the PCR done again right away and then every 3 months afterwards. Zavie Zavie (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 3.8 log reduction Aug/09 e-mail: zmillersympatico (DOT) ca Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 ID: zaviem _____ From: groups (DOT) com [mailto:groups (DOT) com] On Behalf Of Jo-Dee McKibben Sent: October 5, 2009 12:37 PM groups (DOT) com Subject: [ ] Possible Relapse Good Afternoon. I have a question for those of you that were on Gleevec and everything was going well. My last BCR-ABL test showed a tiny increase from .003 to .004. Instead of waiting 6 months to run the test again, Dr. is doing it in 3 months. I know I have been really busy lately but I have been napping on my lunch hour for about the last month or so on and off. This weekend I was so bone tired I could hardly put one foot in front of the other. I have my blood drawn on Wednesday. When the Gleevec started to not work anymore, what were your syptoms? Blessings, Jo-Dee Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2009 Report Share Posted October 6, 2009 High platelets and lots of stomach and abdominal distress. My hemoglobin also dropped into the 8.'s Sent from my iPhone On Oct 5, 2009, at 12:36 PM, Jo-Dee McKibben <tuskarawaz64@...> wrote: Good Afternoon. I have a question for those of you that were on Gleevec and everything was going well. My last BCR-ABL test showed a tiny increase from .003 to .004. Instead of waiting 6 months to run the test again, Dr. is doing it in 3 months. I know I have been really busy lately but I have been napping on my lunch hour for about the last month or so on and off. This weekend I was so bone tired I could hardly put one foot in front of the other. I have my blood drawn on Wednesday. When the Gleevec started to not work anymore, what were your syptoms? Blessings, Jo-Dee Quote Link to comment Share on other sites More sharing options...
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