Guest guest Posted August 31, 2009 Report Share Posted August 31, 2009 Hi Mark, I lost my response to Gleevec (Imatinib) in 2004 which was found on a routine FISH test. I had four out of 200 positive cells and my onc IMMEDIATELY referred me to a clinical trial for Sprycel (Dasatinib). By the time I had a BMB, within a week -- I had 8 out of 20 positive cells. I was first denied entrance into the clinical trial closest to me geographically but tried again elsewhere, Within a couple of weeks I was 100% positive (20 out of 20 cells) when I was accepted to a dasatinib trial at the University of land. Within 3 months after starting that trial I was PCRU and have remained at that level for about 3 1/2 years now. What I learned from this experience is that you must move very QUICKLY. Loss of response happens very fast. Sprycel (dasatinib) has worked very well for me with no apparent side effects but there are other therapies as well which others on this site may address. Best of luck. Let us know if you have further questions. L [ ] Glivec Failure Hi all, I was DX in October 2008 with Chronic Phase CML, I had a marvelous response coming from 113.553% baseline to 0.468% which was my result in April 2009. However in my July PCR it came back as an increase to 18.204%. I had the standard retest done which came back at 48% which I guess is a definate Glivec failure. I have had a BMA done last week and they are currentley carrying out a mutation test at the Hammersmith. I know that there are many individuals that fail Glivec and move onto other TKI's due to mutations etc. Does anyone have an experience similar to this as I would be interested to understand what your approach, actions etc were. I want to makesure that I am asking the right questions and making sure the right tests are being done. I know we have many long term CMlers on the site and would appreciate any information experiences you may have. Best wishes Mark Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 31, 2009 Report Share Posted August 31, 2009 > Hi thank you for your reply I totally agree lose of response does happen quickly which has happened in my case, as stated in my previous post they have seen this and immediately done a BMA and a mutation test. I blieve they are looking a Gleevec levels as well. My doc is looking at a change to Dasatinib or Nilotinib dependant on the test results. I was hoping they would start straight away but I guess they need to understand what the problem is?? Thanks Mark > Hi Mark, > > I lost my response to Gleevec (Imatinib) in 2004 which was found on a routine FISH test. I had four out of 200 positive cells and my onc IMMEDIATELY referred me to a clinical trial for Sprycel (Dasatinib). By the time I had a BMB, within a week -- I had 8 out of 20 positive cells. I was first denied entrance into the clinical trial closest to me geographically but tried again elsewhere, Within a couple of weeks I was 100% positive (20 out of 20 cells) when I was accepted to a dasatinib trial at the University of land. Within 3 months after starting that trial I was PCRU and have remained at that level for about 3 1/2 years now. > > What I learned from this experience is that you must move very QUICKLY. Loss of response happens very fast. > > Sprycel (dasatinib) has worked very well for me with no apparent side effects but there are other therapies as well which others on this site may address. > > Best of luck. Let us know if you have further questions. > > L > [ ] Glivec Failure > > > Hi all, > > I was DX in October 2008 with Chronic Phase CML, I had a marvelous response coming from 113.553% baseline to 0.468% which was my result in April 2009. However in my July PCR it came back as an increase to 18.204%. > > I had the standard retest done which came back at 48% which I guess is a definate Glivec failure. I have had a BMA done last week and they are currentley carrying out a mutation test at the Hammersmith. > > I know that there are many individuals that fail Glivec and move onto other TKI's due to mutations etc. Does anyone have an experience similar to this as I would be interested to understand what your approach, actions etc were. > > I want to makesure that I am asking the right questions and making sure the right tests are being done. I know we have many long term CMlers on the site and would appreciate any information experiences you may have. > > Best wishes > > Mark > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 31, 2009 Report Share Posted August 31, 2009 Hi , You make a strong point for PCR testing more often than every 6 months. Suppose someone starts relapsing shortly after their PCR test. It will be at least 5 months before they test again. I hate to think where you would be if you were in that situation and only tested 5 months later. Zavie Zavie (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 e-mail: zmiller@... Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 ID: zaviem YM: zaviemiller Skype: Zavie _____ From: [mailto: ] On Behalf Of seloew12 Sent: August 31, 2009 9:14 AM Subject: Re: [ ] Glivec Failure--Mark Hi Mark, I lost my response to Gleevec (Imatinib) in 2004 which was found on a routine FISH test. I had four out of 200 positive cells and my onc IMMEDIATELY referred me to a clinical trial for Sprycel (Dasatinib). By the time I had a BMB, within a week -- I had 8 out of 20 positive cells. I was first denied entrance into the clinical trial closest to me geographically but tried again elsewhere, Within a couple of weeks I was 100% positive (20 out of 20 cells) when I was accepted to a dasatinib trial at the University of land. Within 3 months after starting that trial I was PCRU and have remained at that level for about 3 1/2 years now. What I learned from this experience is that you must move very QUICKLY. Loss of response happens very fast. Sprycel (dasatinib) has worked very well for me with no apparent side effects but there are other therapies as well which others on this site may address. Best of luck. Let us know if you have further questions. L [ ] Glivec Failure Hi all, I was DX in October 2008 with Chronic Phase CML, I had a marvelous response coming from 113.553% baseline to 0.468% which was my result in April 2009. However in my July PCR it came back as an increase to 18.204%. I had the standard retest done which came back at 48% which I guess is a definate Glivec failure. I have had a BMA done last week and they are currentley carrying out a mutation test at the Hammersmith. I know that there are many individuals that fail Glivec and move onto other TKI's due to mutations etc. Does anyone have an experience similar to this as I would be interested to understand what your approach, actions etc were. I want to makesure that I am asking the right questions and making sure the right tests are being done. I know we have many long term CMlers on the site and would appreciate any information experiences you may have. Best wishes Mark Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.