Guest guest Posted October 28, 2009 Report Share Posted October 28, 2009 I seldom post but always read everyones posts. I was diagnosed 3 years ago and started on Gleevec at 800 but because of neutropenia I went to 600, then 400, and now currently I am on 200. I had been doing well until this past few months I have seen a slight increase in my PCR results. 07/09 b3a2 was .405, and my last results 10/09 was .236. My b2a2 that was once undetectable on 07/09 was .002 and is now at .012. Should I be worried with this increase? Any feed back would be greatly appreciated. Thanks, e Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 29, 2009 Report Share Posted October 29, 2009 e, Neutropenia is normal for those of us on Gleevec. It took almost five years for my white cell count to get to the low normal range. My question for you is this, " How experienced is your oncologist with CML and Gleevec. " The reason I ask is that no one should be on 200MG of Gleevec. 400 is the minimum therapeutic dose. Gleevec works differently from normal Chemo, with normal Chemo a low wbc would be a danger signal, but not with Gleevec, a low count is NORMAL! This is very important! Even a Great " old school " oncologist needs to be trained in Gleevec. It is a very different animal! You should, at least, go to a university hospital or major cancer hospital and get a second opinion... it can save your life!!! Don't be afraid to hurt some ones feelings, your life is at stake. When you go for your opinion, take all of your CBC results as well as your PCR results. If you tell us where you live there may be someone in the group who can recommend a doctor or medical center. Best wishes, Troxel On Wed, Oct 28, 2009 at 3:13 PM, jonesdjkj <jonesdjkj@...> wrote: > > > I seldom post but always read everyones posts. I was diagnosed 3 years ago > and started on Gleevec at 800 but because of neutropenia I went to 600, then > 400, and now currently I am on 200. I had been doing well until this past > few months I have seen a slight increase in my PCR results. > 07/09 b3a2 was .405, and my last results 10/09 was .236. My b2a2 that was > once undetectable on 07/09 was .002 and is now at .012. Should I be worried > with this increase? Any feed back would be greatly appreciated. > Thanks, > e > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 29, 2009 Report Share Posted October 29, 2009 , Thanks for your reponse. I live in Colorado, about 100 miles south of Denver. The oncologist I see is well respected here and is part of the Rocky Mountain Cancer Centers. I have mentioned to him that I would like to try going to 300MG, and he is afraid I would not tolerate that level well. My white cell count ranges from 600-1200. I will have a bone marrow bx done in 3 weeks. Once that is complete I am going to try to get an appointment at OHSU. I just don't know exactly what it means to now have the b2a2 transcipt popping up all of the sudden. Any information on that would be great. Kritine > > > > > > > I seldom post but always read everyones posts. I was diagnosed 3 years ago > > and started on Gleevec at 800 but because of neutropenia I went to 600, then > > 400, and now currently I am on 200. I had been doing well until this past > > few months I have seen a slight increase in my PCR results. > > 07/09 b3a2 was .405, and my last results 10/09 was .236. My b2a2 that was > > once undetectable on 07/09 was .002 and is now at .012. Should I be worried > > with this increase? Any feed back would be greatly appreciated. > > Thanks, > > e > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 29, 2009 Report Share Posted October 29, 2009 Hi e, I would be concerned about the suboptimal dose you're on. It has been shown that doses lower than 300mg can induce drug resistance. The first thing I would ask for is a blood serum test to determine how much of the drug you are absorbing. In very rare cases, a suboptimal dose has been shown to be safe but you need to confirm that that's the case from serum testing if you're going to proceed with such a protocol. Given your unusual situation, I would really encourage you to seek an expert consultation. Good luck, Tracey > > I seldom post but always read everyones posts. I was diagnosed 3 years ago and started on Gleevec at 800 but because of neutropenia I went to 600, then 400, and now currently I am on 200. I had been doing well until this past few months I have seen a slight increase in my PCR results. > 07/09 b3a2 was .405, and my last results 10/09 was .236. My b2a2 that was once undetectable on 07/09 was .002 and is now at .012. Should I be worried with this increase? Any feed back would be greatly appreciated. > Thanks, > e > Quote Link to comment Share on other sites More sharing options...
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