Histidine as a mercurial poisoning inhibitor

[Guest guest]

This is information only, not a suggested treatment, it is not even

a human study. Personally, we had a very marked response to a

histidine supplement, but then there were some days of irritability,

that is when we went to carnosine. I have yet to find anything

negative on the internet (including medline) on carnosine.

Biochem Biophys Res Commun 2000 Jul 14;273(3):816-9

Histidin as a mercurial poisoning inhibitor.

Myshkin AE, Khromova VS

Institute of Biochemical Physics of the Russian Academy of Sciences,

Kosygin St. 4, Moscow V-334, 117977, Russia.

myshkin@...

Histidin has been shown to effectively inhibit coagulation of horse

oxyhemoglobin (HbO(2)) modified by mercury(II) ion bound to

reactive thiol groups of protein. Kinetic parameters were measured and

the histidin-to-mercury binding constant was kinetically

estimated. Histidin, as other pharmaceutically acceptable compounds with

some mercury-binding capacity, has been suggested to

alleviate mercury intoxication conditions. Copyright 2000 Academic

Press.

MeSH Terms:

Animal

Histidine/pharmacology

Histidine/chemistry*

Horses

Kinetics

Mercury Poisoning/prevention & control*

Methemoglobin/chemistry

Substances:

Methemoglobin

Histidine

PMID: 10891329, UI: 20351183