Re: Question from jxqyz1 - Interesting Hypothesis To Control HIV/...

[Guest guest]

's comments are very useful. I would like to note that for those of you on a major regimen of supplements but not yet on ARV treatment, you will need to screen your supplements against any antiretroviral meds if/when you DO go on treatment. There are some supplements that have to be discontinued (e.g., St. 's Wart, melatonin, etc.) if you are on certain ARVs.

www.aidsmeds.com has a handy tool that allows you to enter all of your meds and supplements; it will screen for interactions and give you information on any interactions and their seriousness (low, mediu, and high).

J

Jerome WeingartStart the year off right. Easy ways to stay in shape in the new year.

[Guest guest]

On Jan 4, 2008, at 2:39 PM, solarjerom@... wrote:'s comments are very useful.  I would like to note that for those of you on a major regimen of supplements but not yet on ARV treatment, you will need to screen your supplements against any antiretroviral meds if/when you DO go on treatment.  There are some supplements that have to be discontinued (e.g., St. 's Wart, melatonin, etc.) if you are on certain ARVs.Really? The SJW may be a problem and yes, probably should be avoided. Milk thistle is probably fine (read the original study).But melatonin? This is an interesting one. See, e.g.,http://www.springerlink.com/content/6xpypdapbundvxfd/(Abstract below).It's late and I'm probably just forgetting, but which ARVs does it negatively affect? M. ** Reduction of Serum Melatonin Levels in HIV-1-Infected Individuals’ Parallel Disease Progression: Correlation with Serum Interleukin-12 LevelsJournal InfectionG. Nunnari1 Contact Information, L. Nigro2, F. Palermo2, D. Leto2, R. J. Pomerantz1 and B. Cacopardo2(1) The Dorrance H. Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Dept. of Medicine, Jefferson Medical College, Jefferson University, Jefferson Alumni Hall 1020 Locust Street, Suite 329, Philadelphia, PA USA, 19107(2) Dept. of Internal Medicine and Medical Specialties, Unit of Infectious Diseases, University of Catania, Catania, ItalyReceived: 25 March 2003  Accepted: 10 September 2003  Abstract.Background:   During the natural history of human immunodeficiency virus type I (HIV-1) infection, an impairment of interleukin-12 (IL-12) production precedes a switch from a T-helper 1 (Th1) to a T-helper 2 (Th2) stage of cellular immunity. Melatonin, the main hormone produced by the pineal gland, seems to promote a Th1 response by increasing the production of IL-12 in vitro. The aim of this study was to measure and correlate serum levels of melatonin and IL-12 in a cohort of HIV-1-infected individuals.Patients and Methods:   77 anti-HIV-1-positive subjects were enrolled: 20 were in CDC stage A, 25 in CDC stage B and 32 in CDC stage C. 30 healthy HIV-1-seronegative subjects were recruited as controls. IL-12 and melatonin concentrations were quantitated in serum samples.Results:   Mean levels of serum melatonin were significantly lower in HIV-1-infected individuals in comparison with controls (p < 0.001). Within the HIV-1-seropositive group, mean melatonin and IL-12 concentrations were significantly lower in patients in CDC stage C, as compared with patients in CDC stages B and A (p < 0.01).Conclusion:   During the natural history of HIV-1 disease, serum melatonin levels are progressively reduced. This reduction may be related to the impairment of Th1 immunoresponses.

[Guest guest]

That drug interaction tool is a GREAT reference. Thanks for pointing it out! Re: Question from jxqyz1 - Interesting Hypothesis To Control HIV/...

's comments are very useful. I would like to note that for those of you on a major regimen of supplements but not yet on ARV treatment, you will need to screen your supplements against any antiretroviral meds if/when you DO go on treatment. There are some supplements that have to be discontinued (e.g., St. 's Wart, melatonin, etc.) if you are on certain ARVs.

www.aidsmeds. com has a handy tool that allows you to enter all of your meds and supplements; it will screen for interactions and give you information on any interactions and their seriousness (low, mediu, and high).

J

Jerome WeingartStart the year off right. Easy ways to stay in shape in the new year.

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