Guest guest Posted March 19, 2000 Report Share Posted March 19, 2000 That's very interesting, . In my husband's family, there have been three people in four generations with trisomy 21. His grandmother's brother, his uncle (her son) and aunt's pregnancy (which they did not have), and our son . It's not translocation, just trisomy 21. I think there must be some connection, but the doctors tell me it's just coincidence and everything I've read says the same. Maybe they'll discover some connection in future research. (mom of (DS) and ) Very interesting . Are you in contact with these families? Re: Situation From: " " <lauranra@...> > You thought maybe twins, one with Ds is unusual...listen to this. I just > met a mother and a daughter who each have a child with Down syndrome. The > mother's child is 4, and Laurie, her daughter, has a 3 month old with Ds. > Both are straight trisomy 21 too! They really want to find anyone else in > the world with this going on. I remember being sooooo excited (still am) to > find all of you. Does anyone remember how that happened. I think it had > something to do with ? Did I find you on another Ds website? Forgive > my ailing mind. Hi ; From what I have seen (I might be wrong) a mother and her daughter both having children with trisomy 21 down syndrome is more common then twins, one with ds. I know of two families in my area where a mother and her daughter both have children with down syndrome....but the exception is that the mother's child with ds is alot older then the daughter's child with ds. I believe when I was on the listserve (1-2 years ago now) that there were several families where someone had a child with ds along with a sibling with trisomy 21. BTW My hubby's cousin had a baby exactly 5 months after and Nicala were born and the baby has trisomy 21 too. There does seem to be some type of familiar pre disposition to trisomy 21 ds...IMO. ------------------------------------------------------------------------ GET A NEXTCARD VISA, in 30 seconds! Get rates as low as 2.9% Intro or 9.9% Fixed APR and no hidden fees. Apply NOW! 1/936/1/_/598201/_/953473168/ ------------------------------------------------------------------------ http://DSyndrome.com/Multiples ____________________________________________________________________ Get your own FREE, personal Netscape WebMail account today at http://webmail.netscape.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 19, 2000 Report Share Posted March 19, 2000 > That's very interesting, . In my husband's family, there have been three > people in four generations with trisomy 21. His grandmother's brother, his > uncle (her son) and aunt's pregnancy (which they did not have), and our son > . It's not translocation, just trisomy 21. I think there must be some > connection, but the doctors tell me it's just coincidence and everything I've > read says the same. Maybe they'll discover some connection in future research. > > > (mom of (DS) and ) One thing that science has just recently realized (some of you probably know what I am talking about) is that 74% of trisomy 21 mothers have a MTHFR mutation. I have this particular mutation myself. 40% of the population has this mutation so it can't be the ONLY contributing factor to trisomy 21 but it would make sense to have it more in one family then another (since the mutation is hereditary). I cut and pasted some of my editorial comments from our March newsletter. , mom to twins Nicala & ,ds (3) and (1) On page 8 you will notice a summary (written by Dr. ) of a research study that was done on the causes of Down syndrome. I participated in this study and found the results to be very informative. I have the full report that was published in American Journal for Clinical Nutrition (the study was FDA funded and approved) and would be willing to send a copy to anyone interested. Approximately 74% of mothers who have a child with Down syndrome have one or both copies of the gene affected (MTHFR: Methelenetetrahydrofolate Reductase). Since I have this mutation and my homocysteine levels are high I am taking folic acid, B6, B12 and TMG. People with this mutation usually have high homocysteine, which is a cardiac risk. This news is all fairly new to the medical profession so be prepared for your Dr. to be unaware of this. I would suggest having your homocysteine levels tested. Ideal levels are 6-8 micro-mol/Liter. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2000 Report Share Posted March 23, 2000 In a message dated 3/19/00 2:40:52 PM Eastern Standard Time, cabevizzo@... writes: << . I think there must be some connection, but the doctors tell me it's just coincidence and everything I've read says the same. Maybe they'll discover some connection in future research. >> HAS ANYONE ACTUALLY BEEN TESTED TO SEE IF THEY ARE A CARRIER? BECAUSE OUR FAMILY HAS TWO WITH DS, MOST OF US HAVE NOW BEEN TESTED TO CHECK OUT OUR GENES....MY HUSBANDS AND DAUGHTER'S WERE FINE, BUT...I, THE MOM, AM A CARRIER. MY GENES ARE A BALANCED TRANSLOCATION, BUT THERE IS A 50/50 CHANCE THAT EACH OF MY CHILDREN COULD BE CARRIERS. MY DAUGHTER IS OK BUT TWO OF OUR OTHER BOYS HAVE NOT YET BEEN TESTED DR. LEICHTMAN EXPLAINED TO US THAT AS A CARRIER, WITH EACH PREGNANCY ONE OF FOUR SITUATIONS WILL HAPPEN...I WILL MISCARRY, OR I WILL HAVE A CHILD WITH DS, OR I WILL HAVE A NORMAL CHILD, OR I WILL HAVE A NORMAL CHILD WHO IS A CARRIER. I HAVE INDEED HAD 3 MISCARRIAGES, 2 WITH DS, AND 3 OTHER NORMAL CHILDREN WHO HAVE NOT ALL BEEN TESTED YET. SO, HAVE ANY OF THE REST OF YOU WITH MORE THAN ONE DS CHILD BEEN TESTED? PEGGY....PLEASE FORGIVE THE CAPITAL LETTERS, I WAS HOLDING A SLEEPY BABY AND TRYING TO TYPE SO ALL CAPS HELPED! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2000 Report Share Posted March 23, 2000 Peggy- Both my sister and I have children with DS. She is 13 years older than me (no siblings in between-my Mom could not get pregnant and then I was an accident!) She had Jim when she was 28 years old. I had Alyssa when I was 35. After my nephew was born 21 years ago, my sister and her husband were tested--but there was no indication that she was a carrier. After was 2 years old, we tried for three years to have a child--only results were 2 miscarriages. A few specialists indicated that I should also be tested since the miscarriages may have occurred because of the history of DS. I turned out NOT to be a carrier as was also the result for my sister. Two years later, we bacame pregnant---had the AFP performed and the results showed risk due to my age and multiple birth. Refused to have an amnio done because it didn't matter to me what the twins had---we had waited too long to have more kids and did not want to risk it. **I am a scientist and believe what our Geneticist stated--We (possibly my side but my husband also has a cousin (37 years) with DS) may be suffering from " Sticky Genes " --Some of the genes may be sticky and slower than the others during cell division--and if this occurs, there may be a higher chance for the extra chromosome. **Even though my kids will likely come out as not being carriers--they may still have a chance of having a child with DS. In our case it seems as if testing may not tell us anything more about our chances. Fran Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2000 Report Share Posted March 23, 2000 Peggy, I am . I have 6 1/2(DS) and Dayton 21months(DS). I was 18 when I had . We found out she was Transloaction 13. So that meant test on me and hubby. I am a carrier for DS. WHY? I don't know we have went back for the last 4generations and can not find anyone in my family with DS. WEIRD.... I knew my chances were in the middle to have another. At the time were medical science was, my chances were 1 in 100. I got pregnat 4yrs later and WE did not do any testing to know before hand. The only thing we did was grade 2 or 3 ultrasound. Everything was borderline for DS. So no definte or anything. He was born also with the same type of DS. So my chances now are 1 in 5. So baby factory is closed here for just this reason. I have always wanted 4 children so adoption is on my plate now. WELL LATER IN THE FUTURE. ----------------------------------------------------- Click here for Free Video!! http://www.gohip.com/freevideo/ Re: [RE: Situation] >From: PeggyLago@... > >In a message dated 3/19/00 2:40:52 PM Eastern Standard Time, >cabevizzo@... writes: > ><< . I think there must be some > connection, but the doctors tell me it's just coincidence and everything I've > read says the same. Maybe they'll discover some connection in future >research. >> >HAS ANYONE ACTUALLY BEEN TESTED TO SEE IF THEY ARE A CARRIER? BECAUSE OUR >FAMILY HAS TWO WITH DS, MOST OF US HAVE NOW BEEN TESTED TO CHECK OUT OUR >GENES....MY HUSBANDS AND DAUGHTER'S WERE FINE, BUT...I, THE MOM, AM A >CARRIER. MY GENES ARE A BALANCED TRANSLOCATION, BUT THERE IS A 50/50 CHANCE >THAT EACH OF MY CHILDREN COULD BE CARRIERS. MY DAUGHTER IS OK BUT TWO OF OUR >OTHER BOYS HAVE NOT YET BEEN TESTED >DR. LEICHTMAN EXPLAINED TO US THAT AS A CARRIER, WITH EACH PREGNANCY ONE OF >FOUR SITUATIONS WILL HAPPEN...I WILL MISCARRY, OR I WILL HAVE A CHILD WITH >DS, OR I WILL HAVE A NORMAL CHILD, OR I WILL HAVE A NORMAL CHILD WHO IS A >CARRIER. >I HAVE INDEED HAD 3 MISCARRIAGES, 2 WITH DS, AND 3 OTHER NORMAL CHILDREN WHO >HAVE NOT ALL BEEN TESTED YET. >SO, HAVE ANY OF THE REST OF YOU WITH MORE THAN ONE DS CHILD BEEN TESTED? >PEGGY....PLEASE FORGIVE THE CAPITAL LETTERS, I WAS HOLDING A SLEEPY BABY AND >TRYING TO TYPE SO ALL CAPS HELPED! > >------------------------------------------------------------------------ >GET A NEXTCARD VISA, in 30 seconds! Get rates as low as 2.9% >Intro or 9.9% Fixed APR and no hidden fees. Apply NOW! >1/936/1/_/598201/_/953825318/ >------------------------------------------------------------------------ > >http://DSyndrome.com/Multiples > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.