VAERS Reports - Mitochondrial Disorders 1990-2007

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121253

pt adm to hosp 19NOV98 w/new onset sz;dx rapidly progressive

necrotizing encephalitis;clinically thought to be most consistent

w/mitochondrial cytopathy although studies pending;autopsy showed

meningoenchephalitis w/hemophagocytosis Cerebral haemorrhage

Cerebral infarction Cerebrovascular disorder

Convulsion Encephalitis Immune system disorder

150001

" The pt experienced a fever, knot at the injection site for an

extended period, fussiness, irritable, loss of skills, language,

comprehension etc. 60 day follow-up dated 7/10/00 provided a

corrected age. Annual follow-up states the pt has metabolic

disturbances, mitochondrial problems, GI issues, PDD. Pt is now a 3

year, 9 month old child with a diagnosis of Autism Spectrum

Disorder/Pervasive Developmental Disorder. Pt has been referred for a

neurological consultation by his pediatrician. Pt was seen previously

for a neurologial examination in June of 1998. He returns today to

review his developemental and neurological status, to examine his

educational and therapeutic interventions and to determine whether

any adjustments or amendments need to be made in his overall program

plan. Pt was accompanied to this assessment by his parents who

provided much of the background information. Currently, pt has now

gotton some words and is trying to imitate sounds made by others. His

parents are pleased that he is now making more of an effort, whereas

before he simply became frustrated. Words which he tends to use with

some reasonable consistency include mam, go, bye, and dada. He has

also learned to shake his head yes or no appropriately and is

developing the use of the " " H " " constanant sounds. He currently

recognizes 19 letters, all of his shapes and colors and he is

currently working on generalization and can point to shapes in a

book. Play skills have like wise improved as has eye contact. He has

a tendency to become fixated on the same four viseo tapes but rarely

asks for television. He ossupies himself with toys and can play alone

for more than an hour. SOme perserverate behavior and play behavior

however, can be exhibited. In terms of dressing skills, pt is now

able to take off his shoes and socks and is otherwise able to help

with dressing. However, he requires a good deal of repetition. From

the health perspective, pt has been in good health and there has been

no major medical issues. However, he continues to have eczem "

Agitation Aphasia Autism Gastrointestinal disorder

Injection site mass Mental impairment

169634

" Child seen on 2/28/01 for well child 2 month exam. Received DTAP,

HIB, Prevnar and HEP-B. Child seen on 4/12/01 for " " fussy and stiff

with decreased smile X 2 weeks " " . Child hospitalized. (+) RSV

(bronchiolitis) on 2/16/01, treated with Augmentin. After exam, it

was revealed spasticity and abnormal eye movements. She was seen by

neurosurgery, neurology, development and genetics. The present

concensus is that pt may have a metabolic disease. Parents state

child is waking up more at night and screaming. Child was put on

apnea monitor for swallowing disorder. Shows signs of cerebral

palsy/eye movement disorder. Has persistent URI. He was also found to

have bilateral otitis media and treated with Amoxil. Annual report

dated 05/02/2003: Diag death 2 hours to genetic mitochondrial Dz.

Date of death: 10/03/2001. " Brain oedema Cerebral atrophy

Cerebral haemorrhage Dysphagia Irritability

Musculoskeletal stiffness

185160

" Information has been received from a health professional concerning

an 18 yea rold male with a serious mitochondrial genetic disorder and

underlying condition of complete muscle spasms who on 07/05/2001 at

3pm was vaccinated with one dose of varicella vaccine. The pt did not

experience any local injection site problems. On approx. 07/05/2001,

the pt developed amplified complete muscle spasms. It was reported

that " " the family and the nurse are not sure if the vaccine is the

cause, but nurse reported that there are some medications that have

amplified his muscle spasms inthe past. " " The pt reportedly goes

through cycles of muscle spasms, but these have been worse since

receiving the vaccine. The pt sought unspecified medical attention.

Additional info has been requested. " Condition aggravated

195749

" Paralysis affecting left arm, leg and facial features. Hospitalized

after Dr's office visit on 11/11/02. Parents told two blood clots in

brain. Treatment-physical therapy one baby aspirin daily. Diagnosed

with opening between atria of heart. Being treated for mitochondrial

defect and blood clotting disorders. In process of recovery. On 60-

day followup report received 04/25/2003, reporter states, " " Patient

was tested at Mayo's after Vx and they found a hole in his heart and

said it was not Vx-related. Pt is going back to Mayo's in 5 months to

see if hole in heart has closed. " " Annual follow up on

04/21/04: " " Pt has recovered from adverse event. " " " Paralysis

Thrombosis

233744

Diagnosed at 26 months with PDDNOS. Confirmed mercury toxicity,

mitochondrial disorder, measles, immune dysfunction, gut dysbiosis by

board certified pediatrician, board certified medical doctor, board

certified pediatric neurologist, board certified neurologist and

psychologist between 42 months and 53 months. Currently being

treated with DAN! protocol to support immune system and repair gut

dysbiosis and chelation to remove mercury poisoning caused by

thimerosal in vaccines. Drug toxicity Endocrine disorder

Gastrointestinal disorder Immune system disorder Viral

infection

270406

Irritability, dizziness and unexplained vomiting episodes presenting

at around 13-14 months followed by rapid neurologic decline including

severe hyper and hypotonia. Resulted in loss of walking ability,

speech, etc. Diagnosed with rapidly progressive, fatal neurologic

disease. Has since regained most function and appears to have CP

most likely attributed to viral illness of unknown origin. (ADEM+

Accute diseminated encephalitis) Does not appear to have chronic

neurolic disease as first diagnosed. MRI has dramatically improved

over last 6 years. Outcome = Cerebal Palsy. 01/16/07-records

received and reviewed form Thorrez MD DX: degenerative

encephalopathy possibly due to a mitochondrial disorder.

Leukodystrophy, unclear cause. Developmental regression followed by

plateau and associated leukodystrophy. Which makes us think that it

is a mitochondrial disorder whereas the spectroscopy shows some

evidence against that. Abasia CSF lymphocyte count CSF white

blood cell count Cerebral palsy Demyelination Dizziness