The Danger of Excessive Vaccination During Brain Development

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The Danger of Excessive Vaccination During Brain Development

The Case for a Link to Autism Spectrum Disorders

By L. Blaylock, M.D.

In 1976, children received 10 vaccines before attending school. Today

they will receive over 36 injections. The American Academy of Pediatrics

and the Center for Disease Control assured parents that it was safe to

not only give these vaccines, but that they could be given at one time

with complete safety.

Is this true? Or are we being lied to on a grand scale?

The medical establishment has created a set of terms, which they use

constantly to boost their egos and firm up their authority as the unique

holders of medical wisdom–the mantra is “evidence-based medicine”,

as if everything outside their anointing touch is bogus and suspect. A

careful examination of many of the accepted treatments reveals that most

have little or no scientific “evidence-based” data to support it.

One often repeated study found that almost 80 percent of medical practice

had no scientific backing.

This is not to say that medical practice should be purely based on pure

and applied science, as understood in the fields of physics and

chemistry. Medicine, as pointed out by many of the great men of medicine,

is an art. For a discussion on the proper role of medicine I refer the

reader to my paper titled –Regimentation in Medicine and the Death of

Creativity – on my website

(www.russellblaylockmd.com

).

The Scientific Double Standards of Vaccine

Safety

Most men of medicine recognize that some things are obvious without a

placebo controlled, double-blind, randomized study. For example, there

has never been such a study to see if smashing your finger with a hammer

will be painful, but we accept it without such pristine evidence. The

same is true with removing brain tumors or sewing up severe

lacerations.

I find it interesting that there exist an incredible double standard when

it comes to our evidence versus theirs.

The proponents of vaccination safety can just say they are safe, without

any supporting evidence what-so-ever, and it is to be accepted without

question. They can announce that mercury is not only safe, but that it

seems to actually increase the IQ, and we are to accept it. They can

proclaim thimerosal safe to use in vaccines without their having ever

been a single study on its safety in over 60 years of use, and we are to

accept it.

Yet, let me, or anyone else, suggest that excessive vaccination can

increase the risk of not only autism, but also schizophrenia and

neurodegenerative diseases, and they will scream like banshees –Where

is the evidence? Where is the evidence?

When we produce study after study, they always proclaim them to be

insufficient evidence or unacceptable studies. More often than not, they

just completely ignore the evidence. This is despite the fact that we

produce dozens or even hundreds of studies that not only demonstrate the

link clinically and scientifically, but also clearly show the mechanism

by which the damage is being done –even on a molecular level. These

include cell culture studies, mixed cell cultures, organotypic tissue

studies, in vivo animal studies using multiple species and even

human studies.

To the defenders of vaccine safety-our evidence is never sufficient and,

if we face reality – never will be.

Scientific Nitpicking Costs Lives

When I was in medical school, there was no proof that cigarette smoking

cause lung cancer. The connection was as obvious as the layman’s

observation that smashing your finger with a hammer would cause pain and

even the town drunk knew it was true, but to the medical elite –there was

no proof.

No one had ever produced lung cancer in animals by exposing them to

cigarette smoke. In fact, my pathology professor, Dr. Jack Strong, had

trained monkeys to chain smoke, and after years of smoking none developed

lung cancer. Yet, he was convinced that smoking caused lung cancer.

Dr. Alton Oschner, founder of the famed Oschner Clinic in New Orleans,

led the charge in proclaiming the link between cigarette smoking and lung

cancer. It took almost another decade before the medical elite was

willing to admit that smoking caused most cases of lung cancer.

Almost 30 years passed from the time some iconoclastic men of medicine

tried to convince the medical establishment that smoking caused most

cases of lung cancer until it was generally accepted.

The question that needs to be asked is – How many people died of lung

cancer, the most prevalent cause of cancer death in the United States,

during this time?

Data from the National Cancer Institute estimated that in the year 2004,

157,000 people died of lung cancer. If 80 percent were secondary to

smoking that would be 125,000 dead. Over a ten-year period that would be

over one million dead and over 30 years almost 4 million people who died

from a preventable cause of death that at the time was still being hotly

debated by the medical purist. Lung cancer death rates were actually

higher during that time period.

So we see that questions of medical importance that are nitpicked to

death on points of scientific purity can cost a lot of lives –millions of

lives.

The Compelling Link Between Autism and the

Vaccination Program

There are over one million children and even adults with autism

and the numbers continue to grow. This is a medial disaster of monumental

proportions.

The link to the vaccine program is scientifically and logically

compelling but these same medical elitists refuse to listen. Like smoking

and lung cancer, we have enough proof today to call a halt to the present

excessive vaccine program and ban any level of mercury in

vaccines.

In 1983, before the autism epidemic began, children received 10

vaccinations before attending school and the autism incidence was 1 in

10,000. Today they are receiving 24 vaccines before 1 year and 36 by the

time they attend school and the autism rate is now 1 in 150 births.

Medical “experts” have provided no other explanation for this dramatic

and sudden rise in autism cases, despite a draconian effort to find

one.

They attempted to say it was genetic, but geneticists were quick to

respond that genetic disorders do not suddenly increase in such

astronomical proportions. They then said it was because of better

diagnosis, despite the fact that the diagnosis is obvious in virtually

every case and that the criteria officially accepted for diagnosis has

become more restrictive not less.

When trapped by a lack of evidence, defenders of a nefarious position

resort to their old standby –the epidemiological study.

Statisticians will tell you that the least reliable type of study is an

epidemiological study because it is easy to manipulate the data so that

the study tells you anything you wish it to.

Every defense offered by vaccine defenders is based on such studies and

never the actual science. Then they announce that the issue is settled

and no further studies need be done. After the media has been informed

that the issue has been settled, those who continue to present the

evidence are considered kooks and the great unwashed ignorant.

The Autism Disaster: Is It Man Made?

Today, specialists speak of the autism spectrum disorders (ASD),

which include a number of related neurodevelopmental disorders such as

classical autism, Rett’s syndrome, Asperger’s syndrome, childhood

disintegrative disorder (CDD) and pervasive developmental disorders not

otherwise specified (PDD-NOS).

I have noticed over the years that when specialists know very little

about a disorder, they spend an inordinate amount of time naming and

sub-classifying it –periodically.

In addition they go to great lengths to define characteristics and

symptoms of the disorder that must be present to meet the criteria of

classification. Those who fail to meet these criteria are dispensed with

into another dimension, that is, they are ignored.

In the early 1980s, the incidence of autism was 1 in 10,000 births. By

2005, the incidence had leaped to 1 in 250 births and today it is 1 in

150 births and still climbing.

One of the strongest links to this terrible set of disorders was a

drastic change in the vaccine programs of the United States and many

other countries, which included a dramatic increase in the number of

vaccines being given at a very early age.

No other explanation has been forthcoming from the medical elite.

In this paper I shall present evidence, some of which has not been

adequately discussed, that provides strong evidence for a connection

between excessive vaccination and neurodevelopmental disorders.

In a paper I wrote in 2003, I stated that removing the mercury from

vaccines would help relieve the problem, but it would not eliminate it.

This was based on a number of studies in the neuroscience literature that

indicated that excessive and especially repeated immune stimulation could

result in severe disruption of brain development and even

neurodegeneration.

In this paper and a follow-up paper, I attributed the central mechanism

to excessive and prolonged microglial activation with an interaction

between inflammatory cytokines and glutamate receptor subtypes. The

Vargas et al study, published two years later in 2005, strongly supported

this hypothesis, with the finding of elevated inflammatory cytokines as

well as the presence of extensive, widespread activated microglia and

astrocytes in examined autistic brains from age 5 years to 44 years of

age.

This indicated that the brain’s immune activation persisted for

decades.

Recent research indicates that this phenomenon is not that uncommon and

can be reproduced in the laboratory using a variety of immune stimulating

agents and neurotoxins, including mercury and aluminum.

Autoimmunity and Vaccinations

A number of studies have suggested a link between autoimmune

disorders and autism risk.

Support comes from studies showing an increased risk of ASD in children

of mothers with autoimmune disorders.1-3 Yet, not all studies

agree, since at least one carefully done study found no strong

link.4

Other more carefully done studies provided evidence suggesting some link.

For example, in one study serum from a mother with an autistic child was

found to bind immunologically with specific brain cells (Purkinje

cells).5 When this serum was injected into pregnant mice,

their babies demonstrated neurological changes suggestive of autistic

behavior, indicating a transfer of the autoantibodies into the developing

baby mouse.

A number of studies have found autoantibodies in a significantly higher

number of autistic children to various brain structures, such as

serotonin receptors, myelin basic protein, neuron axon filament protein,

nerve growth factor and cerebellar neurofilaments.6-10

It should be understood that these autoantibodies are not found in all

cases and that they may develop as a result of the damage caused by the

disease itself, rather than causing the disease. For example, we know

that after a stroke or head injury a substantial number of people will

develop autoantibodies to brain proteins. Nevertheless, the

autoantibodies can worsen the damage and prolong the damaging

pathology.

It has also been demonstrated that methylmercury (from fish) and

ethylmercury (in thimerosal) are both powerful immunosuppressants and are

associated with a high incidence of autoimmunity.11 In this

study, researchers found that unlike methylmercury, thimerosal

(ethylmercury) initially caused immune suppression and then strong

TH2-induced autoimmunity. They attributed this to the higher conversion

of ethylmercury to ionic mercury (Hg+) than seen with

methylmercury.

In fact, one study found that strains of mice highly susceptible to

developing autoimmune diseases were sensitive to the ASD-like behavioral

effects upon mercury exposure, whereas mouse strains genetically not

susceptible to autoimmunity do not develop ASD

behaviors.12

It is obvious from the extremely high incidence of ASD that these

autoimmune-related genes are very common, but they remain silent until

triggered by vaccines or other environmental toxins.

Immunologists have now concluded that autoimmune disorders are not the

result of excessive activation of a normal immune system, but rather

activation of a dysfunctional immune system.

The question remains -- what is causing such widespread immune

dysfunction among our population?

Immune Dysfunction – The Result of “Bystander

Damage”

Studies have shown that the number of autoimmune diseases has increased

over the past 30 years, with asthma, type 1 diabetes and eczema rates

increasing over two-fold. There is also compelling evidence to indicate

that certain vaccinations are associated with these autoimmune-related

conditions.13,14

A compelling number of studies have shown an increased incidence of

autoimmune reactions in children with autism spectrum disorders (ASD),

especially involving measles antigens, milk antigens and antibodies to

gliadin and gluten.15-17 Some of these have been shown to

cross-react with brain-derived proteins as well, especially those in the

cerebellum, a major structure affected in these

disorders.18

Recently, neuroscientists have shown that much of the damage done in

cases of autoimmunity is not due to direct immune reactions with brain

structures, but rather results from the release of storms of free

radicals and lipid peroxidation products during the immune reaction,

something I call a “hand grenade in a shopping mall effect”. If you use a

hand grenade to target a single person in a crowd you will not only kill

and injure the intended target, but all of the bystanders as well.

Neuroscientists P.L. McGeer and E.G. McGeer have named this effect

bystander damage.19

The immune attack caused by the autoimmune reaction in the autistic

person’s brain damages a number of surrounding structures, especially

brain connections called dendrites and synapses. Subsequent studies

have confirmed that bystander damage is the most destructive reaction of

autoimmunity.

Some studies, as referred to above, have shown that autism is much more

common in families with a hereditary tendency for autoimmune diseases,

which makes sense because they will have dysfunctional immune systems.

There is also compelling evidence that vaccines themselves can damage the

immune system of immature animals, leading to a higher incidence of

autoimmunity and abnormal brain development.20-24 Mercury,

even in small concentrations, is also known to induce autoimmunity in a

high percentage of those exposed.11

Ironically, things that suppress a portion of the immune system, usually

cellular type immunity, increase the likelihood of autoimmunity.

Immunologists speak about a Th1 to Th2 shift and vice versa. This can

occur with exposure to mercury as well as in response to

vaccination.25 A great number of autoimmune diseases are

associated with a Th2 shift.

How Immune Reactions to Vaccines Differ

Depending on Age

The immune system is a very complex system, which at birth is

incompletely formed. This means, and has been confirmed in animal and

human studies, that immune reactions to vaccinations differ at different

ages, so that small babies have a different reaction than adults. This

has been shown with the hepatitis B vaccine now given to newborns.

The rate of maturation of the immune system also differs considerably

among babies and children, meaning we cannot say what effect will occur

in all children. There are a great many variables, including diet.

The immune system’s reaction to infection and immunization can be quite

different. Normally the immune system relies on a shifting of

T-lymphocyte function to determine which is better for the particular

situation.26

The T-helper lymphocytes (Th) can exist as either Th1, Th0, or Th2 forms.

When no infection is occurring, the system is in the Th0 mode (an

uncommitted phase). If a virus invades, it quickly switches to the Th1

phase, which allows immune cells to secrete a group of cytokines that

kill viruses. It also activates immune lymphocytes that kill viruses and

bacteria.

At other times, the immune system needs a whole different set of immune

signals and cells, which are supplied by the Th2 phase. The Th2 phase

favors the production of antibodies, mainly supplied by B-cells, but in

general they reduce immune reactions.

Infants are stuck in the Th2 mode during intrauterine life, so as to

prevent being immunologically rejected by the mother during pregnancy

(much like transplant rejection), since the baby is seen as a foreign

body to the mother’s immune system.

Upon birth, the baby remains in a Th2 mode, but has a limited ability to

switch to the Th1 defensive mode if the need arises, say from an

infection. Months later the baby switches to the adult Th1 mode.

If the baby’s immune system remains in a Th2 mode, it has a high risk of

developing an autoimmune disorder, such as eczema, asthma or other

allergies.

Presently, vaccine authorities recommend every baby be vaccinated with

the Hepatitis B vaccine at birth. But, is this safe?

A recent study looked at the immune reaction in newborn infants up to the

age of one year who had received the HepB vaccine to see if their immune

reaction differed from adults getting the same vaccine.27 What

they found was that the infant, even after age one year, did react

differently. Their antibody levels were substantially higher than adults

(3-fold higher) and it remained higher throughout the study.

In essence, they found that the babies responded to the vaccine by having

an intense Th2 response that persisted long after it should have

disappeared, a completely abnormal response.

Autistic Children More Prone to Develop

Autoimmune Diseases and Infections

Autistic children have been described as having a Th2 predominance, which

would explain their propensity to developing autoimmune diseases and

being more susceptible to infections early in

life.20,28-30

Elevated proinflammatory cytokines, particularly TNF-alpha, have been

described in studies of the cytokine profile in autistic children. As we

shall see later, an excess production of B-cell cytokines and suppression

of T-lymphocyte TH1 activity, as seen in autism, is associated with a

high incidence of neurological damage by excitotoxins.

Several things about these immune responses are important to all parents,

including effects of such immune over-stimulation during pregnancy. For

example, it has been shown that excess immune stimulation, as occurs with

vaccination, can significantly increase the risk of a pregnant woman

having a child with autism or schizophrenia later in life, depending on

when the vaccine is given.31.32

In addition, persistent Th2 responses caused by the HepB vaccine puts

your child at a great risk of developing an autoimmune disorder and

impairing your baby’s ability to fight off infections. This means that

immediately after birth this vaccine has put your child at a greater risk

of all childhood related infections, including H. Influenza meningitis,

meningiococcal meningitis, rotavirus, measles, chickenpox, etc.

Not only that, but numerous studies have shown that such immune

suppression greatly increases the number of severe complications

associated with these infections, which means that should your child be

exposed to measles or chickenpox they are more likely to suffer

neurological damage, seizures or other systemic

disorders.12,33,34

When this occurs, rather than admit that the science indicates that the

vaccine program is the cause of the complications and deaths, the vaccine

proponents scream that it demonstrates again the need for greater efforts

to vaccinate our children.

Immune Suppression by Live Virus Containing

Vaccines

It is also known that certain viruses powerfully suppress immunity,

such as the measles virus.35

The MMR vaccine contains live measles viruses and recent studies have

shown that immune suppression after vaccination with this virus

suppresses immunity in a profound way that last as long as six

months.36-41 In fact, the CDC recommends separating this

vaccine from other live virus vaccines to prevent viral overgrowth (Yet,

they combine it with two other live viruses-rubella and mumps

viruses).

Yet, they never address the obvious question – wouldn’t this vaccine also

make the child more susceptible to other naturally occurring infections

such as hemophilus B influenza meningitis, meningococcal meningitis,

persistent measles infection, influenza infection and even

chickenpox? This has been strongly suggested by a number of

studies.42

Not only would they be more susceptible, but severe complications and

even death would be more common as well.

When death and severe complications occur due to these infections,

pediatricians, the CDC and the American Academy of Pediatrics use this as

a justification for more vaccines, never admitting that the increase

incidence of these infections and complications was caused by their

previous vaccine recommendations.

This risk is especially high in families with a number of other children

in the household or in children in day care centers. With a prolonged

suppressed immune system, exposure to other sick children would put this

child at a high risk of contracting the infection and of having

complications or dying from the infection as stated.

Studies have also shown that vaccines that cover only a few strains of a

virus or bacteria that naturally have a great number of strains (some

have over a hundred strains), can cause a shift in strain dominance so

that the strain not included in the vaccine then becomes the dominant

disease causing strain. We see this with the meningiococcal and

pneumococcal vaccines.43-45

This is discussed in the scientific literature but the public is never

informed. Most pediatricians are completely unaware of this.

When combined with mercury, which is also an immune suppressing

substance, the effect is compounded. Fluoroaluminum, formed in

fluoridated drinking water, also interferes with immune function, as do

many insecticides and herbicides used around the home.46

Often forgotten, is the substantial evidence that omega-6 oils powerfully

induce inflammation and immune suppression when consumed in large

amounts. Those eating a Western diet are consuming 50-fold higher amounts

of this type of oil (called linoleic acid) than needed for health. These

oils include corn, safflower, sunflower, canola, peanut and soybean oils.

So, we see that the average child is exposed to a number of substances in

their food and environment that can also alter immunity, making them not

only more susceptible to natural infection, but also to vaccine

complications.

In essence, by over-vaccinating our children, public health officials are

weakening their immune system, making them more susceptible to a number

of infections and less able to combat the infections. This gives them an

endless source of “horror stories” to justify even more vaccines.

Remember also that mercury is an immune suppressant, both from vaccines

and seafood contamination.

One can see that a pregnant mother having dental amalgam fillings, who

eats a diet high in methylmercury-containing seafood, and living in an

area with high atmospheric mercury, such as West Texas, would be at a

greater risk of having an autistic child than one not exposed to these

other sources of mercury.

These differences in environmental mercury exposure are never considered

by those insisting all children have the same vaccines, including

mercury-containing vaccines such as the flu vaccine.

The Autistic Prone Child

What is becoming obvious is that certain children are at a higher

risk of developing autism than others, for a variety of reasons.

It is also obvious that these newborns and small children develop

infections at a higher rate than less vulnerable children. This may be

because of a developmental immune deficiency, which can affect only a

portion of the immune system and so be easily missed by their

pediatrician. Indeed, it has been noted that a great number of cases of

childhood immune deficiencies are missed by practicing pediatricians,

especially the more subtle cases, which may make up the majority of

ASD-prone children.

For example, many physicians treating autistic children have noted a high

incidence of ear infections. These are treated with broad-spectrum

antibiotics, which often lead to a high incidence of Candida overgrowth

in the child’s body.

Both infections will prime the microglia in the child’s brain – which is

the brain’s specific resident immune cell. This priming effect shifts

these normally resting microglia immune cells into

overdrive.47 If stimulated again within weeks or even months,

they generate extremely high levels of free radicals, lipid peroxidation

products, inflammatory cytokines and two excitotoxins glutamate and

quinolinic acid.48

Studies have shown that this is the major mechanism for both viral and

vaccine-related brain injury.

The high incidence of infection in these children indicates the

possibility of preexisting immune system dysfunction. As

stated, this also increases the risk of an autoimmune reaction.

The stage is then set for the autism cascade to develop and this can be

triggered by early vaccination or a recurrent infection. Remember, the

microglia have been primed, either by a natural infection or an earlier

vaccination (such as the hepatitis B vaccine given soon after

birth).

The vaccine is different from a natural infection in that the vaccine

produces brain immune stimulation for very prolonged periods.

It has been proven, in both animal studies and human studies, that

systemic infections or immune activation by vaccines, rapidly activate

the brain’s microglial system and can, in the case of vaccines, do so for

prolonged periods.49-53 Once the primed microglia are

reactivated by the subsequent vaccination or infection, the microglia

activate fully and pour out their destructive elements as discussed

above.

With a natural infection, the immune system quickly clears the infection

and then shuts off the immune activation, thus allowing repair of what

damage was done. This shutting down of the microglia is very important.

There is evidence that with repeated and excessive vaccine-triggered

immune stimulation, the microglia do not shut down.47

This is what was found in the Vargas et al study, in which they

examined the brains of 11 autistics from age 5 years to 44 years of

age dying without active infectious diseases as compared to age matched

controls.54 That is, they found widespread activation of

inflammatory cells (microglia and astrocytes) in the brains of the

autistic patients. This explains the widespread brain damage seen in all

autism cases.

This study was one of the most carefully conducted, extensive

examinations of the immune reactions in the autistic brain ever done and

involved immunocytochemistry, cytokine protein assays and enzyme-linked

immunoascorbant assays of the brain tissue. They also performed similar

assays of spinal fluid from an additional six living autistic patients,

which confirmed the intense immune activation and inflammation.

The average child receiving all of the recommended vaccines will have

some 24 inoculations by age one year and 36 by the time they enter

school.

Most of these will be spaced within one month of each other, which

means the priming and activation cycle of the microglia will be

continuous. In addition, the dose of immune stimulants is excessive.

At birth they receive 1 vaccine, at two months of age they receive 6

additional vaccines, at four months of age 5 vaccines, at age six months

7 vaccines and at age one year, 5 vaccines.

In addition, should they follow the new CDC recommendation, they will

receive the flu vaccine every year starting at age 6 month through age 18

years. These vaccines contain a full dose of thimerosal mercury.

In addition, we must consider the effect of the measles and rubella

portions of the MMR vaccine, which begins at age 1 year. The profound

immune suppression, which last up to 6 months after it is given, will not

only increase the risk of developing other infections, but will increase

the risk of an autoimmune reaction and measles virus persistence in the

brain.

Cytomegalovirus is also a powerful immune suppressing virus that commonly

infects newborns and small children, especially if they are immune

suppressed.

So, we see that giving a live, immunosuppressant vaccine early in life

can dramatically increase the risk of autoimmune disorders, increase

microglial brain injury as well as increase the risk of infection by

other immune-suppressing viruses and pathogenic organisms. And, it

dramatically increases the risk of your child developing one of the

autism spectrum disorders.

It should also be appreciated that the Candida infections in these

children trigger a prolonged systemic immune reaction, which means a

prolonged brain immune response as well and a worsening of any autoimmune

disorder it may have produced.

Seizures and Autism

It is estimated that 30 percent to as high as 82 percent of autistic

children develop seizures, depending on the sensitivity of the

examination.55-56

Growing evidence indicates that there is a close correlation between

brain inflammation (by microglial released inflammatory cytokines and

glutamate) and seizures, just as we see with excessive brain immune

stimulation with vaccines. Using lipopolysacchride as a vaccine-based

immune stimulant, scientists have induced seizures in experimental

animals of various species.57,58

A considerable amount of evidence links excitotoxicity and

seizures.

In addition, a number of the newer anti-seizure medications work by

blocking glutamate receptors or preventing glutamate release. One of the

central mechanisms linking excessive immune stimulation with seizures, as

with vaccines, is the induced release of the excitotoxin glutamate and

quinolinic acid from immune stimulated microglia and

astrocytes.59-61

In many cases these seizures are clinically silent or manifest as

behavioral problems, often not recognized by pediatricians as seizures.

Yet, they can alter brain function and eventually result in abnormal

brain development.

Even the CDC and American Academy of Pediatrics recognizes that infants

and children with a history of seizure should not be vaccinated.

It is also known that autistic children who regress, that is begin to

show a sudden worsening of mental development, have a significantly

higher incidence of seizures, both clinical and subclinical, than those

who do not regress.

Interestingly, studies have shown that during early brain development

after birth the number of glutamate receptors (that trigger the seizures)

increase steadily until the age of two when it peaks.62

Thereafter they decline in number. This means that the immature brain is

significantly more susceptible to seizures than the more mature brain and

this is when your child is being given 24 vaccine inoculations, many of

which are associated with a high incidence of seizure.

Let just use the case of the 1 year-old child who is taken by his mother

for his vaccines and the pediatrician convinces the mother to allow

him/her to give all five vaccines recommended for that age group at that

one office visit. After all, both the CDC and the American Academy of

Pediatrics assures mothers and fathers that it is completely safe to give

them all at once. This not only means that the child’s immune system will

be assaulted by 7 different antigens (viruses, three of which are alive)

but by five full doses of immune adjuvant – a powerful mix of immune

stimulating chemicals.

This intense immune stimulation not only results in a red, swollen and

painful site where the shots were given, but a hyperintense activation of

the brain’s immune system.

Mothers and fathers are familiar with the high-pitched crying their

babies have after such a series of vaccines. Often, this high pitched

crying, lethargy and poor feeding last weeks to months. This is not due

to the pain of the injection, as the pediatrician will assure you, rather

it is secondary to brain inflammation – what we call an encephalitic

cry.63

Combination Vaccines Cause More

Seizures

Recently, information was released that the combination vaccine by Merck,

ProQuid resulted in twice as many seizures as giving the vaccines

separately.

This vaccine contains the MMR antigens as well as chickenpox viral

antigen (in a dose 5x that of the single vaccine). The study was

conducted by comparing 43,000 kids getting the ProQuid vaccine versus

those getting the shots separately. While they attributed the increased

seizures to fever caused by the vaccine, this is only part of the

story.

I have seen a number of febrile seizures during my neurosurgical practice

and my research indicates that the reason some kids are susceptible to

febrile seizures and not others is that the susceptible ones are

deficient in neuroprotective nutrients and are often exposed to

neurotoxic substances, such as mercury and aluminum, that increase

sensitivity to seizures. Consistently found in the studies of febrile

seizures is the presence of low blood sodium levels (called

hyponatremia).64

It is known in neurology that very low sodium blood levels can trigger

seizures, even in normal people. It can also result in rapid coma and

death, especially in a child.

In the presence of brain inflammation, the incidence of hyponatremic

seizures is much higher. One of the major causes of hyponatremia in

infants and small children is the doctor giving IV fluids that contain

little or no sodium chloride (salt). During my practice I constantly

tried to convince pediatricians to stop using D5W (5% dextrose

and water) as an IV solution in sick children, because it induced

seizures. I am convinced that a significant number of children who died

following a meningitis infection actually died of hyponatremia induced by

a combination of the infection and the pediatrician giving hypotonic IV

fluids (D5W) during treatment.

I will always remember the case of a little girl who developed H.

Influenza meningitis and was in a deep coma. The pediatricians consulted

me, suspecting a brain abscess. This was quickly ruled out. I noted the

child was getting D5W as an IV solution. A simple blood test

demonstrated she had severe hyponatremia. Because she was comatose, the

pediatricians wanted me to let her die. I refused. They even went so far

as to approach my partners to have them take me off the case.

Fortunately, they refused to intervene. I corrected her sodium deficiency

and she made a good recovery and had no further seizures.

Studies have also shown that glutamate, as MSG, given to small animals

with immature nervous systems, also increase the likelihood of seizures

from other causes, such as fever.65,66 Excess vaccination,

increases brain levels of glutamate.

Keep in mind that the child by age one will already have had 24 vaccine

inoculations, each spaced no more than one or two months apart. This

means the brain microglia are maintained in a constant primed state. Each

vaccine increases dramatically the damage done by the previous vaccine

series. One is not surprised that so many vaccinated children develop

seizures, often repetitive seizures, or that we have such a high

incidence of autism. And I can assure the elite of the American Academy

of Pediatrics and the CDC that over one million autistic children far

exceeds the danger measles, mumps, diphtheria, chickenpox, tetanus,

rotavirus, HiB meningitis and hepatitis pose to our youth.

Also, keep in mind that for every fully autistic child there are ten

times that many with lesser degrees of impairment.

Compelling evidence indicates that the death rates from the childhood

vaccines fell dramatically in developed countries prior to the mass

vaccination programs, as documented in Neil Z. ’s book,

Vaccines: Are They Really Safe and

Effective?.67

Objective studies attribute the fall in death rates to better nutrition

and improved public sanitation. So, when you hear health authorities warn

that stopping the present vaccine program will mean a return of millions

of children dead from childhood diseases, they are lying and know they

are lying.

Human Brain Development is Different

The human being has an unusual brain development in that there is a

prolonged period of maturation and neuroanatomical pathway development

occurring years after birth. The most rapid brain development occurs

during the last trimester of intrauterine life and two years after birth

– what is referred to as the brain growth spurt. It is the areas

regulating higher brain functions, such as emotions, emotional control,

thinking, complex memory and language function that is last to develop.

Recent studies using functional MRI scans (fMRI) and PET scanning have

shown that brain development continues until about age 26 or 27. Using

such brain mapping techniques as volumetric parcellations that give a 3-D

view of the brain, researchers examined the brains of 13 children

followed for 10 years with scans being done every 2 years.68

What they found is that there was an overdevelopment of synaptic

connections after birth that was slowly removed (called pruning) in

developmental cycles during early childhood and even adolescence.

For example, around age 4 to 8 years there was a thinning of the cortex

in the language areas of the brain (parietal lobes) that spread to the

temporal lobes and finally to the frontal lobes. This thinning moved the

brain into a more functional state of development, that is, it got rid of

unnecessary pathways and connections-sort of a final correction.

Further, they found that the language areas of the brain matured around

age 11 to 13 years and the brain areas controlling higher brain function,

the prefrontal cortex, matured in the mid twenties.69,70

What this means is that during the first two years of life, the child’s

brain is undergoing rapid and very critical development and that the more

advanced cognitive portions of the brain continued their development even

later – much later.

There is compelling evidence that the pruning of these excess synapses is

essential. Otherwise the brain would be inundated with an enormous array

of competing signals – that is a lot of static and misinterpreted

messages. This pruning process, as well as the growth, maturation and

migration of neurons, is carried out by a combination of signals, which

include carefully controlled fluctuating glutamate brain levels and

appearance of specific microglia-released cytokines in a timed

sequence.63,71-75

This is all very exacting and easily disturbed by a number of toxins,

such as mercury and aluminum. It is also critically dependent on the

presence of thyroid hormone.

Anything that alters these fluctuating glutamate and cytokine levels can

affect, sometimes in drastic ways, the development of the brain, which as

we have seen continues far into young adulthood.76-79

Pathological studies of autistic brains demonstrate three areas that are

especially affected –the cerebellum, the limbic brain and

the prefrontal area.80-83

There exist intimate connections between the cerebellum and the

prefrontal cortex and between the prefrontal cortex and the limbic system

– in particular the amygdalar nuclei. These are also areas frequently

affected by inflammatory cytokines during immune stimulation, such as

with vaccinations.84 In the Vargas et al study, the

most intense microglial activation was in the cerebellum.54

In low concentrations, both the cytokines and glutamate act to protect

developing brain cells and promote brain development (neurotrophic

function), but in higher concentrations they can be very destructive,

especially in combination. Of particular importance are the inflammatory

cytokines interleukin 1a and 1ß (IL-1a and IL-ß), IL-6 and tumor necrosis

factor-alpha (TNF-alpha).85-89

Evidence that alteration in these cytokines can cause developmental brain

problems comes in part from studies of schizophrenia, a disorder that can

be produced by stimulating inflammatory cytokine surges during

pregnancy.90-92

Avoid the Flu Vaccine During

Pregnancy

It is known, for example, that women who are infected with the flu during

pregnancy are significantly more likely to give birth to an autistic

child or a child with schizophrenia, depending on when the infection

occurs.

At first, they assumed this was due to the virus being passed to the

fetus, but subsequent studies found that it was not the virus, but the

mother’s immune reaction that cause the problem – that is, it was the

immune cytokines (IL-1, IL-2, Il-8, IL-6 and TNF-alpha) that was causing

the injury to the baby’s developing brain.

The insane policy of having every pregnant woman vaccinated with the flu

vaccine flies in the face of what we know concerning the neurotoxic

effect of excessive immune stimulation during pregnancy. Even if the

vaccine prevented the flu (studies show it reduces it only in a select

few), instead of a small percentage of pregnant women being at risk, they

would make sure every woman was at risk.

Keep in mind these pregnant women will have been receiving the flu shot

(containing mercury) every year since age 6 months (according to present

CDC recommendations), meaning they will have accumulated a significant

amount of mercury and will, as a result, have a hyperintense cytokine

response to the flu vaccine during their pregnancy. In addition,

they will have accumulated a significant amount of neurotoxic mercury.

It is also important to keep in mind that immune activation with

vaccination differs from natural immunity, in that it persist much longer

– even for years following a vaccination. This does not allow the brain

time to repair itself either in the mother or in the unborn child. In

addition, the way the immune system reacts differs with vaccination,

especially in the very young, as we have seen.

A new study from the Weizmann Institute in Israel by Hadas Schori and

co-workers found that with a normally functioning immune system, the

T-lymphocytes actually protected neurons from glutamate excitotoxicity,

but if the immune system was dysfunctional, as seen in most of the ASD

children, the opposite happened.93 That is, stimulating the

immune system was significantly destructive of the brain’s cells. Their

study found that under conditions of immune dysfunction, B-cells

predominated in invading the brain and this dramatically increased the

destructive effect of excess glutamate.

Another study also found that mercury toxicity was greatest in mice prone

to develop autoimmune diseases, thus confirming the above

study.12 Further, the Schori study indicates that even in

animals without an autoimmune-prone genetic makeup, suppression of

T-lymphocyte function increased excitotoxic damage.

Both the measles and cytomegalovirus inhibit T-cell function, as does

mercury and the hepatitis B vaccine.11,27,35,41,

The Vargas et al study also demonstrated that T-lymphocytes failed

to infiltrate the autistic brains examined, meaning that protective

T-lymphocyte protection was not in evidence.54 Under these

conditions, systemic immune activation, as seen with multiple and

sequential vaccinations, would increase the excitotoxic damage caused by

the microglial and astrocytic activation.

When all the evidence is taken together, these studies provide powerful

evidence that sequential, multiple vaccinations in newborns and small

children maximizes the inflammation of the brain and as a consequence

dramatically enhances the excitotoxic pathology, and does so for

prolonged periods (decades).

The more vaccines that are added to the vaccine schedule, the more

frequently this devastating effect will be seen and in worse forms.

What About the Adjuvants Used in

Vaccines?

While mercury has gotten all the attention, aluminum (found in most

vaccines) is also a major culprit in this shocking saga.

Added to most vaccine are a number of substances either used during

manufacturing or designed as an immune booster (adjuvant). These include

albumin, aluminum (either as aluminum hydroxide, aluminum phosphate or

alum also known as aluminum potassium sulfate), various amino acids, DNA

residues, egg protein, gelatin, monosodium glutamate (MSG), MRC-5

cellular protein and various antibiotics.

Not listed on official lists are bacterial and viral contaminants, which

can include their particulate, fragmented matter.94-99

The purpose of the aluminum compounds is to dramatically boost the immune

reaction to the vaccine and make it prolonged, since some of the aluminum

remains in the site of injection for years.

Aluminum was first added to vaccines in 1926. Many of the other

components added to the vaccines also boost immunity, especially that of

undesirable components of the immune system, such as the B-cells.

Because these vaccine adjuvants are designed to produce a prolonged

immune stimulation, they pose a particular hazard to the developing

nervous system. Studies have shown that immune activation can last as

long as two years after vaccination. This means that the brain’s

microglial cells are also primed for the same length of time, and

possibly longer.

A new emerging syndrome called macrophagic myofasciitis has been

attributed to the aluminum adjuvant in vaccines and is especially

associated with the hepatitis B vaccine and the tetanus

vaccine.100 Victims of this syndrome suffer severe muscle and

joint pains and severe weakness. Subsequent studies, since the syndrome

was first described in France, indicate widespread, severe brain injury

as well, as confirmed by MRI scanning.101,102 This brain

syndrome has been described in American children as well.

It is known that aluminum accumulates in the brain and results in

neurodegeneration. The evidence for a link between aluminum neurotoxicity

and Alzheimer’s disease continues to grow stronger. Aluminum, like

mercury, activates microglia leading to chronic brain inflammation, which

is a major event in both Alzheimer’s disease and Parkinson’s

disease.103-110

Flarend and co-workers studied the fate of vaccine injected aluminum in

the dose approved by the FDA (0.85 mg per dose) using radiolabeled

aluminum adjuvant –either aluminum hydroxide or aluminum phosphate, the

two approved forms of adjuvants used in vaccines.111

They found that the aluminum was rapidly absorbed into the blood from

both forms of aluminum, but that the aluminum phosphate was absorbed

faster and produced tissue levels 2.9x higher than aluminum

hydroxide. Blood levels of aluminum remained elevated for 28 days

with both adjuvants. Elevated aluminum levels were found in the kidney,

spleen, liver, heart, lymph nodes and brain.

This indicates that aluminum from vaccines is redistributed to numerous

organs including brain, where it accumulates. Each vaccine adds to this

tissue level of aluminum. If we calculate the aluminum dose from 36

vaccines, we see that the total dose is 30.6 mg and not the 0.85 mg

considered safe by the FDA. Of course not all this aluminum ends up in

the tissues, but they will accumulate substantial amounts, especially

when added to the amount from foods and drinking water. When a number of

aluminum-containing vaccines are given during a single office visit,

aluminum blood levels rise rapidly and to much higher levels and this

elevation persist for over a month, all the time infiltrating the

tissues, including the brain with aluminum.

It is also known that aluminum enhances the toxicity of mercury and that

aluminum, even from other sources, increases inflammation in the

body.106

The question no one seems to be asking is -- does the aluminum act as a

constant source of brain inflammation? Research, especially that showing

aluminum-triggered microglial activation, seems to indicate it

does.112

Dr. , Strunecka, a professor of physiology, found that aluminum

readily binds with fluoride to form fluoroaluminum and that this compound

can active G-protein receptors, which controls a number of

neurotransmitters, including glutamate receptors.46

Giving multiple aluminum-containing vaccines at once would raise blood

and tissue levels much higher than when give separately, thus increasing

brain levels as well. Fluoride in drinking water, foods and dental

treatments would react with the brain aluminum, creating the neurotoxic

fluoroaluminum combination. Studies have shown that fluoride also

accumulates in the brain.

The Role of Mercury in Developmental Brain

Damage

Mercury also activates microglia and does so in concentrations below

0.5 microgram (3 to 5 nanograms).113 This is well below the

concentration seen with giving mercury-containing vaccines to

children.

Ethylmercury, like its cousin methylmercury, enters the brain very easily

but once within the brain it is de-ethylated, forming ionic mercury

(Hg+).114

There is evidence that ionic mercury is significantly more neurotoxic

than organic mercury. Once it is converted, the mercury is difficult, if

not impossible, to remove. Studies using monkeys demonstrated that ionic

mercury is redistributed in the brain.115

This same series of studies also demonstrated that there was extensive

microglial activation in the monkey’s brain and it persisted over 6

months after the mercury dosing was stopped, indicating that even when

the plasma mercury disappears the brain mercury

remains.116

This is important to remember when you hear from the vaccine safety

promoters that new studies have shown that ethylmercury (in thimerosal)

disappears from the blood within several days. Actually, the mercury

leaves the plasma and enters the brain, where it is de-ethylated and

remains for a lifetime.

What they fail to mention is that recent studies have shown that only 7

percent of methylmercury is converted to ionic mercury, whereas 34

percent of ethylmercury is converted within a short time.117

This means that more of the most destructive form of mercury is retained

in the brain following mercury-containing vaccine exposure than exposure

to mercury from fish.

They also fail to mention that the vaccine-based mercury that was removed

from the blood enters the stool in high concentrations, where it

recirculates repetitively, meaning that with each cycle the mercury has

access to the brain.

Mercury has another link to this immune/excitotoxic reaction. A number of

studies have shown that mercury, in submicromolar concentrations,

interferes with the removal of glutamate from the extracellular space,

where it causes excitotoxicity.118-120

This removal system is very important, not only in protecting the brain

but also in preventing abnormal alterations in brain

formation.121 As you will recall, it is the carefully

programmed rise and fall in glutamate levels in the brain that allow the

brain’s pathways to develop and for proper development of its connections

(called synaptogenesis).

Another way mercury damages the brain is by interfering with its energy

production.

The mitochondria of the neuron (the energy factory) accumulate more

mercury than any other part of the cell. It is known that when you

interfere with the neuron’s ability to produce energy, you greatly

magnify its sensitivity to excitotoxicity, so much so that even

physiological concentrations of glutamate can become

excitotoxic.122-125

One of the destructive reactions of both excitotoxicity and mercury

toxicity is the generation of storms of free radicals and lipid

peroxidation products. Essential to the protection of brain cells is the

antioxidant enzymes (catalase, glutathione peroxidase and SOD). Mercury

poisons these protective enzymes.

One of the most important protective systems is the glutathione molecule,

which is present in every cell in the body. Mercury dramatically lowers

glutathione levels by a number of mechanisms. (See Dr. Boyd Haley’s work

for more information).126 So, we see that mercury can greatly

aggravate this entire destructive mechanism.

It is important to appreciate that as important as mercury is, it is not

the lone essential element in this process. Rather, essential to this

process is a combination of pre-existing or vaccine-induced immune

dysfunction and excess immune stimulation by a crowded vaccine

schedule.

This is why autism will not go away, even when mercury is completely

removed from all vaccines.

It also important to appreciate that mercury can never be removed from

the picture because of the numerous sources of mercury in our

environment, such as contaminated seafood, atmospheric mercury and dental

amalgam.

Why Males Are Affected More Often

One of the enigmas of autism is why it occurs in males more often than

females.

Actually there are a number of toxins that have this gender selectivity.

Studies have shown, for example, that both mercury and monosodium

glutamate (MSG) have greater neurotoxicity in males than

females.127

The reason appears to be the enhancing effect of testosterone on both

substances’ toxicity.128,129

Glutamate is the most abundant neurotransmitter in the brain and operates

through a very complex series of receptors (3 major inotropic receptors-

NMDA, AMPA and kainate receptors, and 8 metabotropic receptors). As

stated, the presence of glutamate outside brain neurons, even in very

small concentrations, is brain cell toxic. Because of this, the brain is

equipped with a very elaborate series of mechanisms to remove glutamate

quickly, primarily by utilizing glutamate uptake proteins

(EAAT1-5).

Mercury, aluminum, free radicals, lipid peroxidation products and

inflammatory cytokines can easily damage these. 130,131

One of the important ways glutamate regulates neuron function is by

allowing calcium to enter the cell and by the release of calcium within

cell storage depots. When calcium (glutamate operated) channels are

opened, the calcium flows in as a wave of concentrated calcium. These are

referred to a calcium waves or oscillations. They regulate a number of

neuron functions, one of which plays a vital role in brain development.

During brain development, the future neurons are lined up along membranes

within the core of the undeveloped brain. These cells must migrate

outwardly to reach their final destination and they do so by guided

chemical signals mainly released by microglia and astrocytes. These

trillions of connections also develop during a process called

synaptogeneis, and use many of the same signals.

Studies have shown that the calcium waves cause developing brain cells to

migrate, which is essential for development of the brain (it forms the

architectonic structures and functional columns of the

brain).132

Interestingly, testosterone also affects embryonic brain cell migration

by regulating calcium waves, and mercury, probably by stimulating

glutamate release, does the same thing.133 Estrogen reduces

calcium oscillations and stops the migration. Other chemical signals in

the brain also play a role (reelin).

If calcium oscillations are not properly regulated, that is -- there are

too many calcium oscillations, the brain develops abnormally.

Testosterone and glutamate have an additive effect on these calcium

waves. In this way, testosterone enhances the damaging effect of

excessive glutamate and mercury.

Studies have shown that higher doses of MSG during brain formation can

cause abnormalities of brain development that closely resemble mercury

poisoning and the toxic effects of high levels of inflammatory

cytokines.76 Interestingly, vaccination has been shown to

significantly increase the toxicity of several other neurotoxins, so much

so that they can trigger brain cell destruction or synaptic loss even

when subtoxic concentrations of the toxicants are used. Testosterone

aggravates this toxicity as well.

Studies of autistic children show an elevated level of androgens in most,

even in female autistic children.134 In general, androgens,

such as testosterone, enhance neurological injury and estrogens tend to

be protective of the brain.135

The Role of the Leaky Gut Phenomenon and Food

Intolerances

Wakefield and his co-workers demonstrated a connection between the

MMR vaccines and abnormal gut function in a landmark article appearing in

the journal Lancet in 1998.136

In this carefully conducted study they biopsied the lining of the

intestines of autistic children having GI symptoms and demonstrated

lymphocytic infiltration as well as elevated levels of inflammatory

antibodies and cytokines. TNF-alpha release was particularly high from

these gut-based immune cells. The entire GI tract, from the stomach to

the colon, was infiltrated by these immune cells.

Subsequent studies have shown a high incidence of abdominal pain,

bloating, diarrhea and constipation in children with

ASD.138,139 A number of other studies have shown problems with

digestive enzymes, defective detoxification, and an overgrowth of a

number of pathogenic bacteria and fungi in the colon and intestine of ASD

children.140,141

Not surprisingly, a few studies have shown significant improvement in

behavior when ASD children are placed on diets devoid of identified food

allergens.142-144 Antibodies to food components, such as

casein, gliadin and gluten have also been described as well as

cross-reactions between food antigens and brain

components.145

One disease that closely resembles the case of ASD in terms of brain

injury associated with food allergins is celiac disease, in which there

is an immune sensitivity to the food components gliadin and gluten.

Approximately 6 percent of such patients will demonstrate neurological

damage, most frequently cerebellar ataxia.146 Other studies

have also found seizures, cranial nerve damage, dementia and impaired

frontal lobe function.147-151

Autopsy studies indicate that the most commonly found neurological damage

occurs in the cerebellum, as we see in autism. Other studies have shown

an immunologic cross-reactivity between gluten antibiodies and Purkinje

cells in the cerebellum.144

Like the celiac cases, in autism the most intense microglia activation

and neuronal loss occurred in the cerebellum. In many of the cases of

autistic brains examined, virtually all of the Purkinje cells were

lost.54

Studies looking for the incidence of GI symptoms in autistic children

indicate that from 20 percent to 84 percent will have complaints. It is

interesting to note that in the studies on celiac-related neurological

problems, only 13 percent complained of GI symptoms, so ASD children can

have gut-related brain effects without obvious GI

symptoms.151

Some feel that the gliadin, casein and gluten can be converted to

opioid-like substances, such as gliadomorphin and casomorphin that can

produce a morphine response in the brain, leading to abnormal

behavior.152,153 These opioids also suppress immunity and

increase excitotoxicity.154

While the opioid effect exists, I feel it is the recurrent immune

stimulation of primed microglia that is causing most of the damage seen

in autism.155

Studies have also found frequent dysbiosis in autistic children, that is,

an overgrowth of pathogenic bacteria and fungi and a loss of beneficial

probiotics organisms.138

It has been demonstrated that Candida organisms can penetrate the gut

wall and enter the blood stream, were they can be distributed to all

tissues and organs, including the brain.156 The same is true

for pathogenic bacteria and bacterial toxins. These brain implanted

organisms act as continuous sources of immune stimulation, which is

especially damaging to the brain because of vaccine-triggered microglia

priming and/or activation occurring before the gut problem presents

itself, with repeated vaccination aggravating the injury.

With each subsequent vaccination, the microglia response is enhanced

because of the recurrent immune activation by food antigens and

microbiological antigens. It is interesting to note that trials of

antibiotic vancomycin, which is not absorbed from the gut, objectively

improved the cognitive function of a number of autistic

children.157 We also know that with children having celiac

disease even a very small amount of the offending food can have

devastating neurological effects.

CONCLUSION

I have presented a considerable amount of evidence for a connection

between the present vaccine schedule and the development of autism

spectrum disorders, yet even this paper is only a brief review of what we

know.

A more in-depth discussion of the immune/excitotoxic will appear in my

paper-- Interaction of activated microglia, excitotoxicity,

reactive oxygen and nitrogen species, lipid peroxidation products and

elevated androgens in autism spectrum disorders. Strunecka

and I are also working on another paper discussing this vaccine-triggered

mechanism, which will appear in an upcoming special autism issue of the

journal Alternative Therapies in Health and

Medicine.

Much of this information is being totally ignored by the medical elite

and especially the media.

The Simsonwood conference proceedings, in which over 50 scientists,

vaccine pharmaceutical company representatives and representatives from

the World Health Organization met secretly in Norcross, Georgia,

disclosed that the safety of your children is not their primary interest

– their only interest is selling vaccines to the public.

A friend of mine, while speaking to an audience of scientists and public

health officials in Italy, was rudely told by a public health official

that (paraphrased) – We all know that vaccines can cause neurological

damage, but we must keep this from the public because it might endanger

the vaccine program.

It is also important to understand that most practicing pediatricians

have never heard what I have disclosed to you. Most have very little

understanding of immune function and have no idea of the pathological

effect on the brain of giving multiple vaccines on a large scale. These

effects are widely discussed in the neuroscience literature, but few

practicing physicians, especially pediatricians, ever read such

articles.

Immunology, like nutrition, gets only scant attention in medical school

and even less in residency training of physicians. Older doctors have no

concept of the newer discoveries in immunology, especially

neuroimmunology.

The human immune system is one of the most complex systems in physiology

and our studies indicate an even greater complexity is to be found.

Despite a renewed interest in the immune system’s function in neonates

and small children, much remains unknown concerning the immune effects of

exposing infants and small children to such a barrage of vaccine early in

life. Yet, what we do know is that they react quite differently than

adults and it can have devastating consequences on brain development and

function.

Vaccinating millions of children with the hepatitis B vaccine at birth

can only be described as dangerous idiocy.

The vast majority of infants, children and adolescents are in no danger

from this infection -- even the medical authorities agree on that. It is

also known that the effectiveness of the vaccine in children last no more

than two years and has little or no effectiveness in the immune

suppressed child.

The nefarious plan by these vaccine geniuses is to force vaccines all

babies, since they would have difficulty convincing adults, that is, the

one at any danger, to get the vaccine.

The problem with this “plan” is that the vaccine is ineffective by the

time the child reaches the age of risk. Now that they have discovered

this, they are recommending that all children have a booster vaccine

every two years.

The American Academy of Pediatrics and the CDC, the forces behind this

vaccine mania, assure parents that giving all of the required vaccines at

once is perfectly safe. As we have seen, the scientific “evidence” does

not support this policy. To do so exposes the child to a high

concentration of immune-stimulating adjuvants that will intensely

activate the brain’s immune system (microglia) during the brain’s most

active growth period, that is, during the first 2 to 6 years of

life.

The maturation and development of the brain continues to a large degree

throughout adolescence. As we have seen, excessive vaccination can result

in brain inflammation and brain swelling that can be prolonged, even

lasting years, if not decades (as we have seen in the Vargas et al

study). This can result in seizures, high pitched crying, severe

lethargy, weakness and behavioral problems, such as agitation,

depression, anger and other autistic behaviors.

In addition, giving the vaccines all at once exposes the brain to higher

levels of neurotoxic aluminum as proven by the radiolabeled aluminum

study quoted above.

If a person were to follow recommended vaccine guidelines they would

receive over 100 vaccines in a lifetime.

Because of the way the vaccines are given, this would not allow the

brain’s microglial cells to shut down, which is essential.

One of the effects of chronic microglial activation, other than brain

inflammation, is an elevation in brain glutamate levels. Studies have

shown this can lead to chronic neurodegeneration and is suspected as a

common mechanism associated with neuropathic viruses, such as the measles

and borna viruses.158-160 In fact, blocking certain of the

glutamate receptors can prevent brain damage by the measles virus, as

well as other viruses.158

We also know that the prognosis of spinal meningitis can be determined by

the spinal fluid glutamate levels, with high levels having the worst

prognosis.161 Studies of autistic children have also shown

elevated glutamate levels in their blood and spinal fluid.

Foods and Supplements For the Autistic

Child

Because excitotoxicity plays such an important role in autism, parents of

autistic children should avoid feeding their children foods containing

excitotoxic additives, such as MSG, hydrolyzed protein, vegetable protein

extracts, soy protein or soy protein isolate, natural flavoring, yeast

enzymes, etc.

There are many disguised names for high glutamate food additives. A

recent study has also shown that there is an interaction between certain

food dyes and glutamate and aspartame that enhances neurotoxicity

significantly.

They should also avoid immune suppressing oils, such as the omega-6 oils

(corn, soybean, peanut, safflower, sunflower and peanut oils). As stated,

people in this country eat 50-times the amount of this immune suppressing

oil than they need for health.

While omega-3 oils are healthy, the EPA component is significantly immune

suppressing and as a result, high intakes should be avoided. Studies have

shown suppressed lymphocyte function (NK cells) with high intake of

EPA.162 It is the DHA component that has most of the

beneficial effects, especially as regards brain repair and inflammation

reduction.163 DHA also inhibits excitotoxicity. Because the

autistic child has intense brain inflammation, a combination of EPA and

DHA is preferable, with a lower content of EPA (no more than 250

mg).

Milk and milk products should be avoided and foods containing gliadin and

gluten should also be avoided.

Soy foods are also responsible for a significant number of food allergies

as well as being very high in glutamate, fluoride and manganese.

Fluoride should be avoided, especially in drinking water. Water is also a

significant source of aluminum in the diet (it is added as a clarifying

agent) and in fluoridated water the fluoride complexes with aluminum to

form the highly neurotoxic fluoroaluminum compound.

The greatest dietary source of aluminum is biscuits, pancakes, black tea

and baked goods made with aluminum-containing baking powder.

Low magnesium intake, which is common in the United States, is associated

with higher degrees of inflammation in the body and lower glutathione

levels. It also enhances excitotoxicity, since magnesium is a natural

modulator of the NMDA glutamate receptor. Low intakes of magnesium

greatly enhance glutamate receptor sensitivity, worsening excitotoxicity.

Low magnesium also lowers brain glutathione levels, which increases brain

sensitivity to mercury toxicity.

Increasing magnesium levels, reduces inflammation, raises glutathione

levels and reduces excitotoxic sensitivity.

A number of flavonoids are neuroprotective, especially against

inflammation and excitotoxicity. These include curcumin, quercetin,

ellagic acid, natural vitamin E (mixed trocopherol), epigallocatechin

gallate (from white tea), theanine, DHEA and hesperidin. All are

available as supplements and most have a high safety profile.

Other Live Vaccine Dangers

The live virus vaccines, such as chickenpox, measles, mumps and rubella,

pose a special danger in the immunosuppressed child, because some of

these viruses can take up permanent residence in the body, including the

brain.

In one study, which examined the tissues of elderly dying of

non-infectious causes, researchers found live measles virus in 45 percent

of the bodies examined and 20 percent of their brains.164,165

These measles viruses were highly mutated, meaning they could result in a

number of diseases not normally suspected with measles infection.

I have omitted discussions about vaccine contamination, which is a major

problem. Several studies found a high incidence of microorganism

contamination in vaccines made by a number of major pharmaceutical

companies, with figures as high a 60 percent of the vaccines being

contaminated.94-99

Bacterial and viral fragments have also been found in a number of

vaccines.

While vaccine promoters were quick to assure us that these viral

fragments should cause no problem, research says otherwise. In

fact, a non-viable viral fragment implanted in microglia and astrocytes

in the brain causes the devastating dementia associated with the HIV

virus.167,168

The virus does not infect the brain neurons themselves. The mechanism

proposed is an immunological/excitotoxic-induced toxicity, just as we see

with repeated vaccination. The same mechanism is seen with a number of

viruses, including measles viruses, borna virus and the herpes

virus.168-172

When brain glial cells or neurons are chronically infected with these

viruses (called a persistent viral infection) the smoldering

immune/excitotoxic reaction slowly destroys the brain cell connections

because the immune system is attempting to destroy the infectious

microorganism. Since it can never kill the organism, the destruction (and

intense microglial activation) continues for decades, as we saw in the

autistic brain.54

The same effect can occur with viral fragments, the Lyme disease

organism, aluminum and mercury that accumulates in the brain from either

contaminated vaccines or from vaccine additives. And because excessive

vaccination, especially with immune-suppressive viruses, can depress

proper immune function, the child is at a greater risk of developing such

a persistent viral infection.

Likewise, they are at a greater risk of developing deadly invasive

bacterial infections, such as H. Influenza meningitis, pneumococcal and

meningiococcal meningitis.

When it occurs, the vaccine promoters scream that we need more vaccines

to protect the children, never admitting that it was the vaccine program

itself that destroyed the lives of these children.

“Universal Health Care” May Increase Vaccine

Danger

While a number of people and even physicians, think they desire a

universal health care system (a euphemism for socialized medicine), here

is something to consider. The government will use access to health care

as a way to mandate vaccinations for all Americans. Those who refuse any

of the mandated vaccines will be denied access to health care, meaning

you will not be able to see a doctor or enter a hospital or clinic.

All federal programs will have completion of vaccine mandates as a

requirement. This could be linked to social security, food stamps,

housing subsidy programs and other such federal programs. Remember, they

use such tactics now for access to schools and daycare centers. One may

even have to prove that they have had all their required vaccinations

before they can use public transportation, such as busses, trains and

airplanes.

Another thing to consider is that the communist Chinese are gradually

taking over vaccine manufacturing. In fact, communist China is now the

largest vaccine manufacturer in the world. They have over 400

biopharmaceutical companies busy making vaccines and poor quality drugs

for the world.

The FDA admits that it inspects only 1.8 percent of the 714 drug firms in

China and that, according to a GAO study, FDA inspections may be done 13

years apart (it is spaced 2 years apart in the United States).

Even more frightening is that the inspectors must depend on Chinese

translators and US companies purchasing these vaccines and

pharmaceuticals must, by agreement, have a Chinese communist official

serve as its legal representative.

According to the Phyllis Schafly Report, one CEO was quoted as saying

“every piece of information you get (from the Chinese) is suspect.”

With thousands of people dying and getting sick, not only in China, but

in hundreds of nations receiving their tainted pharmaceutical products,

this means future vaccines will be an even greater danger.

The risk of millions of Americans and others living in the West receiving

contaminated vaccines is extremely high. It could even be done on

purpose, since the Chinese communist have declared their intention to

defeat the United States.

Infecting over a hundred million Americans with contaminated

vaccines would be an easy way to defeat us. The irony would be that our

public officials would have aided them in our destruction.

Parents must appreciate that those in positions of authority are lying to

them.

Most pediatricians think they are doing what is right, because they too

are victims of years of propaganda by elite members in the CDC and

American Academy of Pediatrics. Most truly believe what they are telling

parents. They should wake up and joint the fight to bring some sense to

this insane policy.

References

1.

Money J et al. Autism and autoimmune disease: A family study. J Autism

Child Schizophr 1971; 1: 146-160.

2.

Comi A. et al. Familial clustering of autoimmune disorders and evaluation

of medical risk factors in autism. J Child Neurology 1999; 14:

388-394.

3.

Sweetwen TL et al. Increased prevalence of familial autoimmunity in

probands with pervasive developmental disorders. Pediatrics 2003: 112:

420.

4.

Creen LA et al. Maternal autoimmune disease, asthma and allergies, and

childhood autism spectrum disorders: a case-control study. Arch Pediatr

2005;159: 151-157.

5.

Dalton P et al. Maternal antibodies associated with autism and language

disorders. Ann Neurol 2003;53: 533-537.

6.

Singh VK, Rivas WH. Prevalence of serum antibodies to caudate nucleus in

autistic children. Neuroscience Lett 2004; 355: 53-56.

7.

Singh VK et al. Antibodies to myelin basic protein in children with

autistic behavior. Brain Behavior Immunol 1993; 7: 97-103.

8.

Singer HS et al. Antibrain antibodies in children with autism and their

unaffected siblings. J Neuroimmunol 2006; 178: 149-155.

9.

Singh VK et al. Circulating autoantibodies to neural and glial filament

proteins in autism. Pediatr Neurol 1997; 17: 88-90.

10.

el-Fawal HA e al. Exposure to methylmercury results in serum

autoantibodies to neurotypic and gliaotypic proteins. Neurotoxicology

1996; 17: 531-539.

11.

Havarinasab S et al. Immunosuppressive and autoimmune effects of

thimerosal in mice. Toxicol Appl Pharmacol 2005; 204; 109-121.

12.

Hornig M, Chian D, Lipkin WJ. Neurotoxic effect of postnatal thimerosal

are mouse strain dependent. Mol Psychiatry 2004; 9: 833-845.

13.

Tishler M, Shoenfeld Y. Vaccination may be associated with autoimmune

disease. Isr Med Assoc J 2004; 6: 430-432.

14.

Shoenfeld T, Aron-Maor A. Vaccination and autoimmunity-‘vaccinosis’ a

dangerous liaison? J Autoimmunity 2000; 14: 1-10.

15.

Vojdam A et al. Antibodies to neuron-specific antigens in children with

autism: possible cross-reaction with encephalitogenic proteins from milk,

Chlamydia pneumoniae and Streptococcus group A. J Neuroimmunol 2002; 129:

168-177.

16.

Lucarelli S et al. Food allergy and infantile autism. Panminerva Med

1995; 37: 137-141.

17.

O’Banion D et al. Disruptive behavior: a dietary approach. J Autism Child

Schizophr 1978; 8: 325-337.

18.

Vojdani A et al. Immune response to dietary proteins, gliadin and

cerebellar peptides in children with autism. Nutr Neuroscience 2004; 7:

151-161.

19.

McGeer PL and McGeer EG. Autotoxicity and Alzheimer Disease. 2000; 57;

289-290.

20.

Malek-Ahmadi P. Cytokines and etiopathogenesis of pervasive developmental

disorders. Med Hypothesis 2001; 56: 321-324.

21.

Weizman A et al. Abnormal responses to brain tissue antigen in the

syndrome of autism. Am J Psychiatry 1982; 139; 1462-1465.

22.

Lee SC et al. Cytokine production by human fetal microglia and

astrocytes. Differential induction by liposaccharide and IL-1beta. J

Immunol 1993; 150: 2659-2667.

23.

Bauer S et al. The neuropoetic cytokine family in development,

plasticity, disease and injury. Nature Reviews/Neuroscience 2007; 8:

221-232.

24.

Boulanger LM, Shatz CJ. Immune signaling in neural development, synaptic

plasticity and disease. Nature Reviews/Neuroscience 2004; 5:

521-531.

25.

Agrawal A et al. Thimerosal induces TH2 responses via influencing

cytokine secretion by human dendritic cells. J Leukocyte Biol 2007; 81:

1-9.

26.

Kidd P. Th1/Th2 balance: The hypothesis, its limitations, and implication

in health and disease. Altern Medicine Rev 2003; 8: 223-246.

27.

OC et al. Hepatitis B immunization induces higher antibody and

memory Th2 responses in new-borns than adults. Vaccine 2004; 22:

511-519.

28.

Cohly HH, Panja A. Immunologic findings in autism. In Rev Neurobiol 2005;

71: 317-341.

29.

Singh VK. Plasma increase of interleukin-12 and interferon-gamma.

Pathological significance in autism. J Neuroimmunol 1996; 66:

143-145.

30.

Jyonouchi H et al. Proinflammatory and regulatory cytokine production

associated with innate and adaptive immune responses in children with

autism spectrum disorders and developmental regression. J Neuroimmunol

2001; 120: 170-179.

31.

Pandey RS et al. Autoimmune model of schizophrenia with special reference

to antibrain antibodies. Biol Psychiatry 1981;16: 1123-1136.

32.

Zhang XY et al Elevated interleukin-2, interleukin-6 and interleukin-8

serum levels in neuroleptic-free schizophrenia: association with

psychopathology. Schizophr Res 2002; 57: 247-258.

33.

W et al. Measles associated encephalopathy in children with renal

transplants. Am J Transplant 2006; 6: 1459-1465.

34.

Larner AJ, Farmer SF. Myelopathy following influenza vaccination in

inflammatory disorder treated with chronic immunosuppression. Eu J Neurol

2000; 7: 731-733.

35.

Kerdile YM et al. Immunosuppression by measles virus: role of viral

proteins. Rev Med Virol 2006; 16: 49-63.

36.

Abernathy RS, Spink WW. Increased susceptibility of mice to bacterial

endotoxins induced by pertussis vaccine. Fed Proc 1956; 15: 580.

37.

Auwaerter PD et al. Changes within T-cell receptor V beta subsets in

infants following measles vaccinations. Clin Immunol Immunopathol 1996;

79: 163-167.

38.

Hussey GD et al. The effect of Edmonston-Zagreb and Schwartz measles

vaccines on immune responses in infants. J Infect Dis 1996; 173:

1320-1326.

39.

Hirsch RL et al. Measles virus vaccination of measles seropositive

individuals suppresses lymphocyte proliferation and chemotactic factor

production. Clin Immunol Immunopath 1981; 21: 341-350.

40.

Daum RS et al. Decline in serum antibody to the capsule of Haemophilus

influenza type b in the immediate postimmunization period. J Pediatrics

1989;1114: 742-747.

41.

Pukhalsky AL et al. Cytokine profile after rubella vaccine inoculation:

evidence of the immunosuppressive effect of vaccination. Mediators

Inflammation 2003; 12: 203-207.

42.

NZ. Vaccine Safety : For Concerned Families and Health

Practioners. New Atlantean Press, NM, 2008.

43.

Pichichero ME et al. Pathogen shifts and changing cure rates for otitis

media and tonsillopharyngitis. Clin Pediatr 2006; 45: 493-502.

44.

MR et al. Impact of conjugate vaccine on community wide coverage of

nonsusceptible Streptococcus in Alaska. J Inf Dis 2004; 190:

2031-2038.

45.

Pichichero ME, Cary JR. Emergence of a multiresistant serotype 19A

pneumococcal strain not included in the 7-valent conjugate vaccine as an

otopathogen in children. JAMA 2007; 298: 1772-1778.

46.

Strunecka A., Patocka J, Blaylock RL et al. Fluoride interactions: From

molecules to disease. Current Signal Transduction Therapy 2007;

2

47.

Block ML, Zecca L, Hong J-S. Microglia-mediated neurotoxicity: uncovering

the molecular mechanisms. Nature Reviews/Neuroscience 2007; 8:

57-69.

48.

Mandu P, Brown GC, Activation of microglial NADPH oxidase is synergistic

with glial NOS expression in inducing neuronal death: a duel-key

mechanism of inflammatory neurodegeneration. 2005; 2: 20.

49.

Cagnin A et al. In vivo visualization of activated glia by [11C] ®-

PK11195-PET following herpes encephalitis reveals projected neuronal

damage beyond the primary focal lesion. Brain 2001; 124: 2014-2027.

50.

Lemstra AW et al. Microglia activation in sepsis: a case-control study. J

Neuroinflamm 207; 4: 4

51.

Buttini M, Lumonta S, Boddeke HW. Peripheral administration of

lipopolysaccharide induces activation of microglial cell in rat brain.

Neurochem Int 1996; 29: 25-35.

52.

Cunningham C et al. Central and systemic endotoxin challenges exacerbate

the local inflammatory responses and increased neuronal death during

chronic neurodegeneration. J Neurosci 2005; 25: 9275-9284.

53.

Godbout JP et al. Exaggerated neuroinflammatory and sickness behavior in

aged mice following activation of the peripheral innate immune system.

FASEB J 2005;19: 1329-1331.

54.

Vargas DL et al. Neuroglial activation and neuroinflammation in the brain

of patients with autism. Ann Neurol 2005; 57: 67-81.

55.

Blaylock RL. Central role of excitotoxicity in autism. JANA 2003;6:

7-19.

56.

Lewine JD et al. Magnetoencephalographic patterns of epileptiform

activity in children with regressive autism spectrum disorders.

Pediatrics 1999; 104: 405-415.

57.

Auvin S et al. Inflammation exacerbates seizure-induced injury in the

immature brain. Epilepsia 2007; 48: 27-34.

58.

Rizzi M et al. Glia activation and cytokines increased in rat hippocampus

by kainic acid-induced status epilepticus during postnatal development.

Neurobiol Dis 2003; 4: 94-103.

59.

Eastman CL et al. Increased brain quinolinic acid production in mice

infected with hamster neurotropic measles virus. Exp Neurol 1994; 125:

119-124.

60.

Heyes MP et al. Human microglia convert L-tryptophan into neurotoxin

quinolinic acid. Biochem J 1996; 320: 595-597.

61.

Ida T et al. Cytokine-induced enhancement of calcium-dependent glutamate

release from astrocytes mediated by nitric oxide. Neurosci Lett 2008;

432: 232-236.

62.

Ye GL et al. AMPA and NMDA receptor-mediated currents in developing

dentate granule cells. Brain Res Dev Brain Res 2005; 155: 26-32.

63.

Menkes JH, Kinsbourne M. Workshop on neurologic complications of

pertussis and pertussis vaccinations. Neuropediatrics 1990; 21:

171-176.

64.

Kiviravanta T, Airaksinen EM. Low sodium levels in serum are associated

with febrile seizures. Acta Paediatr 1995; 84: 1372-1374.

65.

Bar-Peled O et al. Distribution of glutamate transporter subtypes during

human brain development. J Neurochem 1997; 69: 2571-2580.

66.

Arauz-Contreas J, Feria-Velasco A. Monosodium-L-glutamate-induced

convulsions 1. Differences in seizure pattern and duration of effect as a

function of age in rats. Gen Pharmacol 1984; 15: 391-395.

67.

Neil Z. . Vaccines: Are they Really Safe and Effective? A Parent’s

Guide to Childhood Shots. New Atlantean Press, NM 1999.

68.

Toga Aw et al. Mapping brain maturation. Trend Neurosci 2006; 29:

148-159.

69.

Gogtay N et al. Dynamic mapping of human cortical development during

childhood and adolescence. Proc Natl Acad Sci USA 2006; 101:

8174-8179.

70.

Jerigan TL, Tallal P. Late childhood changes in brain morphology

observable with MRI. Dev Med Child Neurol 1990; 32: 379-385.

71.

Maslinska D et al. Morphological forms and localizations of microglial

cells in the developing human cerebellum. Folia Neuropathol 1998; 36:

145-151.

72.

Monier A et al. Entry and distribution of microglial cells in human

embryonic and fetal cerebral cortex. J Neuropathol Exp Neurol 2007; 66:

372-382.

73.

Schwab JM et al. IL-6 is differentially expressed in the developing human

fetal brain by microglial cells in zones of neuropoesis. In J Dev

Neurosci 2001; 114: 232-241.

74.

Schlett K. Glutamate as a modulator of embryonic and adult neurogenesis.

Curr Top Med Chem 2006; 6: 949-960.

75.

Kumuro H, Rakic P. Modulation of neuronal migration by NMDA receptors.

Science 1993; 260: 95-97.

76.

Marret S et al. Arrest of neuronal migration by excitatory amino acids in

hamster developing brain. Proc Natl Acad Sci USA 1996; 93:

15463-15468.

77.

Aarum J et al. Migration and differentiation of neural precursor cells

can be directed by microglia. Proc Natl Acad Sci USA 2003;100:

15983-15988.

78.

Ekdahl CT et al. Inflammation is detrimental for neurogenesis in adult

brains. Proc Natl Acad Sci USA 2003; 100: 13632-13635.

79.

Chao CC et al. Tumor necrosis factor-alpha potentates glutamate

neurotoxicity in human fetal cell cultures. Dev Neurosci 1994; 16:

172-179.

80.

Kemper TL et al. Neuropathology of infantile autism. J Neuropathology Exp

Neurol 1998; 57: 645-652,

81.

Bauman MI, Kemper TL. The neuropathology of autism spectrum disorders:

What have we learned? Novartis Foundation Symp 2003; 251:

112-122.

82.

Bauman M, Kemper TL. Developmental cerebellar abnormalities: a consistent

finding in early infantile autism. Neurology 1986; 36 (Suppl 1):

190.

83.

Courchesne E. Brainstem cerebellar and limbic neuroanatomical

abnormalities in autism. Curr Opin Neurobiol 1997; 7: 269-278.

84.

Buller KM, Day TA. Systemic administration of interleukin 1beta activates

select populations of central amygdala afferents. J Comp Neurol 202; 452:

288-296.

85.

DL et al. Stimulation of microglial metabotropic glutamate

receptor mGlu2 triggers tumor necrosis factor a-induced neurotoxicity in

concert with microglial-derived Fas ligand. J Neurosci 2005; 25:

2952-2964.

86.

Rothwell NJ. Cytokines-Killers in the brain? J Physiol 1999; 514.1: 3-17.

87.

Samland H et al. Profound increase in sensitivity to glutamatergic –but

not to cholinergic agonist-induced seizures in transgenic mice with

astrocytes production of IL-6. J Neurosci Res 2003; 73: 176-187.

88.

Bernardino L et al. Modulator effects of interleukin-1ß and Tumor

necrosis factor-a on AMPA-induced excitotoxicity in mouse organotypic

hippocampal slice cultures. J Neurosci 2005; 25: 6734-6744.

89.

Allan SM et al. Interleukin-1 and neuronal injury. Nature Reviews/Immunol

2005; 5: 629-640.

90.

Burka SL et al. Maternal cytokine levels during pregnancy and adult

psychosis. Brain Behav Immunol 2001; 15: 411-420.

91.

Brown AS et al. Elevated maternal interleukin-8 levels and risk of

schizophrenia in adult offspring. Am J Psychiatry 2004; 161:

889-895.

92.

Ganguli R et al. Autoimmunity in schizophrenia: a review of recent

findings. Ann Med 1993; 25: 489-496.

93.

Schori H et al. Severe immunodeficiency has opposite effects in neuronal

survival in glutamate-susceptible and resistant mice: adverse effect of

B-cells. J Immunol 2002; 169: 2861-2865.

94.

Cutrone R et al. Some oral polio vaccines were contaminated with

infectious SV-40 after 1961. Can Res 2005; 65: 10273-10279.

95.

Harasawa R, Tomiyama T. Evidence of pestivirus RNA in human virus

vaccines. J Clin Microbiol 1994; 32: 1604-1605.

96.

Geier M et al. Endotoxins in commercial vaccines. Appl Environ Microbiol

1978; 36: 445-449.

97.

Giangaspero M et al. Genotypes of pestivirus RNA detected in live virus

vaccines for human use. J vet Med Sci 2001; 63: 723-733.

98.

Potts BJ et al. Possible role of pestivirus in microcephaly. Lancet

1987;1: 972-973.

99.

JA, Heneine W. Characteristics of endogenous avian leukosis virus

in chicken embryonic fibroblast substrates used in production of measles

and mumps vaccine. J Virol 2001; 75: 3605-3612.

100.

Gherardi RK et al. Macrophagic myofasciitis lesion assess long-term

persistence of vaccine-derived aluminum hydroxide in muscle. Brain 2001;

124: 1821-1831.

101.

Authier F-J et al. Central nervous system disease in patients with

macrophagic myofasciitis. Brain 2001; 124: 974-983.

102.

Bonnefont-Rousselot D et al. Blood oxidative status in patients with

macrophagic myofasciitis. Biomed Pharmacol 2004; 58: 516-519.

103.

Good PF et al. Selective accumulation of aluminum and iron in the

neurofibrilary tangles of Alzheimer’s disease: a laser microprobe (LAMMA)

study. Ann Neurol 1992; 31: 286-292.

104.

Esparza JL et al. Aluminum-induced pro-oxidant effect in rats: protective

role of exogenous melatonin. J Pineal Res 2003; 35: 32-39.

105.

Yokel RA et al. The distribution of aluminum into and out of the brain. J

Inorg Biochem 1999; 76: 127-132.

106.

A et al. Chronic exposure to aluminum in drinking water

increases inflammatory parameters selectively in the brain. J

Neuroscience Res 2004; 75: 565-572.

107.

Bishop NJ et al. Aluminum neurotoxicity in preterm infants receiving

intravenous feeding solutions. N Engl J Med 1997; 336:

1557-1561.

108.

A. Inflammation, neurodegenerative disease, and environmental

exposures. Ann NY Acad Sci 2004; 1035: 117-132.

109.

Shirabe T et al. Autopsy case of aluminum encephalopathy. Neuropathology

2002; 22: 206-210.

110.

Armstrong RA et al. Hypothesis: Is Alzheimer’s disease a metal-induced

immune disorder. Neurodegeneration 1995; 4: 107-111.

111.

Flarend RE et al. In vivo absorption of aluminum-containing vaccine

adjuvants using 26Al. Vaccine 1997; 15: 1314-1318.

112.

Platt B et al. Aluminum toxicity in the rat brain: histochemical and

immunocytochemical evidence. Brain Res Bull 2001; 55: 257-267.

113.

s N. Specificity and reliability of the inhibition by

HgCl2 of glutamate transport in astrocytes cultures. J

Neurochem 1988; 50: 1117-1122.

114.

Vahter ME et al. Demethylation of methylmercury in different brain sites

of Macaca fascicularis monkeys during long-term subclinical methylmercury

exposure. Toxicol Appl Pharmacol 1995; 134: 273-284.

115.

ton JS et al. Changes in the number of astrocytes and microglia in

the thalamus of the monkey Macaca fascicularis following long-term

subclinical methylmercury exposure. Neurotoxicology 1996; 17:

127-138.

116.

ton JS et al. Increase in the number of reactive glia in the

visual cortex of Macaca fascicularis following subclinical long-term

methylmercury exposure. Toxicol Appl Pharmacol 1994; 129:

196-206.

117.

Burbacher TM et al. Comparison of blood and brain mercury levels in

infant monkeys exposed to methylmercury or vaccines containing

thimerosal. Environ Health Perspect 2005; 113: 1015-1021.

118.

Mutkus L et al. Methylmercury alters the in vitro uptake of glutamate and

GLAST and GLT-1 transfected mutant CHO-K1 cells. Biol Trace Elem Res

2005; 107: 231-245.

119.

Aschner M et al. Methymercury alters glutamate transport in astrocytes.

Neurochem Int 2000; 37: 199-206.

120.

Kim P, Choi BH. Selective inhibitors of glutamate uptake by mercury in

cultured mouse astrocytes. Yonsi Med J 1995; 36: 299-305.

121.

Kugler P, Schleyer V. Developmental expression of glutamate transporters

and glutamate dehydrogenase in astrocytes of the postnatal rat

hippocampus. Hippocampus 2004; 14: 975-985.

122.

Yel L et al. Thimerosal induces neuronal cell apoptosis by causing

cytochrome C and apoptosis-inducing factor release from mitochondria. In

J Mol Med 2005; 16: 971-977.

123.

Humphrey ML et al. Mitochondria mediated thimerosal-induced apoptosis in

a human neuroblastoma cell line (SK-N-SH). Neurotoxicology 2005; 26:

407-416.

124.

Henneberry RC. The role of neuronal energy in neurotoxicity of excitatory

amino acids. Neurobiol Aging 1989; 10: 611-613.

125.

Zeevalk GD et al. Excitotoxicity and oxidative stress during inhibition

of energy metabolism. Dev Neurosci 1998; 20: 444-445.

126.

Haley BE. The relationship of the toxic effects of mercury to

exacerbation of the medical condition classified as Alzheimer’s disease.

Medical Veritas 2007; 4: 1510-1524.

127.

Sun YM et al. Sex-specific impairment in sexual and ingestive behaviors

of monosodium glutamate-treated rats. Physiol Behavior 1991;50:

873-880.

128.

Yang S-H et al. Testosterone increases neurotoxicity of glutamate in

vitro and ischemia-reperfusion injury in an animal model. J Appl Physiol

2002; 92: 195-201.

129.

Estrada M et al. Elevated testosterone induces apoptosis in neuronal

cells. J Biol Chem 2006; 281: 25492-25501.

130.

Aschner M et al. Involvement of glutamate and reactive oxygen species in

methyl mercury neurotoxicity. Braz J Med Biol Res 2007; 40:

285-291.

131.

JM et al. The consequences of methylmercury exposure on interactive

function between astrocytes and neurons. Neurotoxicology 2002; 23:

755-759.

132.

Lautermilch NJ, Spitzer NC. Regulation of calcineurin by growth cone

calcium waves controls neurite extension. J Neurosci 2000; 20:

315-325.

133.

Estrada M et al. Ca2+ oscillations induced by testosterone enhance

neurite outgrowth. J Cell Sci 2005; 119; 733-743.

134.

Geier DA, Geier MR. A clinical trial of combined anti-estrogen and

anti-heavy metal therapy in autistic disorder. Neuroendocrinol Lett 2006;

27: 833-838.

135.

Baker AE et al. Estrogen modulates microglial inflammatory mediator

production via interactions with estrogen receptor ß. Endocrinology 2004;

145: 5021-5032.

136.

Wakefield AJ et al. Ileal-lymphoid nodular hyperplasia, non-specific

colitis, and pervasive developmental disorders in children. Lancet 1998;

351: 637-641.

137.

Ashwood P, Wakefiled AJ. Immune activation of peripheral blood and

mucosal CD3+ lymphocyte cytokine profiles in children with autism and

gastrointestinal systems. J Neuroimunol 2006; 173: 126-134.

138.

Horvath K et al. Gastrointestinal abnormalities in children with autistic

disorder. J Pediatr 1999; 135: 559-563.

139.

Afzal N et al. Constipation with acquired megacolon in children with

autism. Pediatrics 2003; 112: 939-942.

140.

Feingold SM et al. Gastrointestinal microflora studies in late-onset

autism. Clin Infect Dis 2002; 35: S6-S16.

141.

Vojdani A et al. Antibodies to neuron-specific antigens in children with

autism: possible cross-reaction with encephalitogenic proteins from milk,

Chlamydia pneumonia and Streptococcus group A. J Neuroimmunol 2002; 129:

168-177.

142.

Lucarelli S et al. Food allergy and infantile autism. Panminerva Med

1995; 37: 137-141.

143.

Knivsberg AM et al. A randomized, controlled study of dietary

intervention in autistic syndrome. Nutri Neurosci 2002; 5:

251-261.

144.

Vojdani A et al. Immune response to dietary proteins, gliadin and

cerebellar peptides with autism. Nutr Neurosci 2004; 7: 151-161.

145.

Whitely P et al. A gluten-free diet as an intervention for autism and

associated disorders: preliminary findings. Autism 1999; m3:

45-65.

146.

Bushara KO. Neurologic presentation of celiac disease. Gastroenterology

2005; 128: S92-S97.

147.

Kinney HC et al. Degeneration of the central nervous system associated

with celiac disease. J Neurol Sci 1982; 53: 9-22.

148.

DeSantis A et al. Schizophrenia symptoms and SPECT abnormalities in a

coelic patient: regression after gluten-free diet. J Intern Med 1997;

242: 421-423.

149.

Beyenberg S et al. Chronic progressive leukoencephalopathy in adult

celiac disease. Neurology 1998; 50: 820-822.

150.

Burk K et al. Sporadic cerebellar ataxia associated with gluten

sensitivity. Brain 2001; 124: 1013-1019.

151. Hu

WT et al. Cognitive impairment and celiac disease. Arch Neurol 2006;63:

1440-1446.

152.

Wakefield AJ et al. Review article: The concept of entero-colonic

encephalopathy, autism and opioid receptor ligands. Aliment Pharmacol

Ther 2002; 16: 663-674.

153.

PK et al. The opioid-cytokine connection. J Neuroimmunology

1998; 83: 63-69.

154.

Zhu L et al. Enhancing effect of beta-endorphins on glutamate toxicity.

Zhongguo Yao Li Xue Bao 1998; 19: 108-111.

155.

Blaylock RL. Interaction of cytokines, excitotoxins, and reactive

nitrogen and oxygen species in autism spectrum disorders. JANA 2003; 6:

21-35.

156.

Rao S, Ali U. Systemic fungal infections in neonates. J Postgrad Med

2005; 51 (suppl 1): S27-S29.

157.

Sandler RH et al. Short term benefit from oral vancomycin treatment of

regressive-onset autism. J Child Neurol 2000; 15: 429-435.

158.

T et al. NMDA-receptor antagonist prevents measles virus-induced

neurodegeneration. Eur J Neurosci 1991; 3: 66-71.

159.

Eastman CL et al. Increased brain quinolinic acid production in mice

infected with a hamster neurotropic measles virus. Exp Neurol 1994;125:

119-124.

160.

Raslet A et al. Borrelia burgdorferi induces inflammatory mediator

production by murine microglia. J Neuroimmunol 2002; 130: 22-31.

161. Ma

W eat al. Elevated cerebrospinal fluid levels of glutamate in children

with bacterial meningitis as a predictor of the development of seizures

or other adverse outcomes. Pediatr Crit care Med 2003; 4:

170-175.

162.

Zhao Y et al. Eicopentaenoic acid prevents LPS-induced TNF-alpha

expression by preventing NFkB activation. J Amer Coll Nutr 2004; 23:

71-78.

163.

Weldon SM et al. Docosahexaenoic acid induces an anti-inflammatory

profile in liposaccharide-stimulated THP-1 macrophage mice more

effectively than eicosapentaenoid acid. J Nutr Biochem 2007; 18:

250-258.

164.

Katayama Y et al. Detection of measles virus nucleoprotein mRNA in

autopsied brain tissue. J Gen Virol 1995; 76: 3201-3204.

165.

Katayama Y et al. Detection of measles virus mRNA from autopsied human

tissues. J Clin Microbiol 1998; 36: 299-301.

166.

Hult B et al. Neurobiology of HIV. Int Rev Psychology 2008; 20:

3-13.

167.

-Sarano F, - J. the neuropathogenesis of AIDS. Nat

Rev Immunol 2005; 5: 69-81.

168.

Rubin SA et al. Viral teratogenesis: brain developmental damage

associated with maturation state at time of infection. Brain Dev Rev

1999; 112: 237-244.

169.

Lellouch-Tubiana A et al. Immunocytochemical characterization of

long-term persistent immune activation in human brain after herpes

simplex encephalitis. Neuropathology Appl Neurobiol 2000; 26:

285-294.

170.

Ovanesov MV et al. Activation of microglia by Borna disease virus

infection: In vitro study. J Virol 2006; 80: 12141-12148.

171.

Volmer R et al. Borna disease virus infection impairs synaptic

plasticity. J Virol 2007; 81: 8833-8837.

172. De

la Torre JC. Borna virus and the brain. J Infect Dis 2002; 186: (suppl2)

: S241-S247.

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Sheri Nakken, former R.N., MA, Hahnemannian

Homeopath

Vaccination Information & Choice Network, Nevada City CA & Wales

UK

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http://www.wellwithin1.com/vaccine.htm Vaccine Dangers &

Childhood Disease & Homeopathy Email classes start April 18