Vitamin B12 Levels May Be Linked to Reduced Risk of Rectal Cancer

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" Plasma vitamin B12 concentrations and the risk of colorectal cancer:

a nested case-referent study, " Dahlin AM, Van Guelpen B, et al, Int J

Cancer, 2008; 122(9): 2057-61.

Summary: In a nested, case-referent study involving 226 subjects with

colorectal cancer and double matched referents, plasma concentrations

of vitamin B12 were found to be inversely associated with risk of

rectal cancer. The univariate odds ratio of rectal cancer was 0.34 for

subjects in the highest versus the lowest quintile of vitamin B12

plasma concentration.

On the other hand the corresponding univariate odds ratio for colon

cancer was 1.25, about which the authors state, " The observed

over-risk was attributable to left-sided colon cancer. " These results

suggest that increasing levels of vitamin B12 may reduce the risk of

rectal cancer.

Mooney

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