Re: Dr Graveline Article and Info for a New Statin Study

[Guest guest]

Hello Group,

I spoke with Kern (study coordinator) today at 716-829-2695

(Buffalo, NY). There are 2 ongoing studies (funded by NIH - National

Institute of Health) and both are open to participants Worldwide.

Participation is reimbursed. One study requires a blood draw and the

other a mouth swab (looking for CPT2 gene deficiencies). Both study

samples need to be shipped to their lab in Buffalo, NY.

All applicants would need to speak with directly as she files and

mails all necessary paperwork - cover letter, questionnaire, consent

form & confidentiality agreement.

I plan to call Dr. Vladutiu this Thursday to inquire about any studies

that are looking at memory loss & neurological impairments ICW statins.

Fran

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VOLUNTEERS TAKING CHOLESTEROL-LOWERING DRUGS

NEEDED FOR RESEARCH STUDY

The Guthrie Biochemical Genetics Laboratory at the Buffalo

General Hospital, Kaleida Health, and the University at Buffalo is

currently looking for individuals who have been taking

cholesterol-lowering drugs (statins) for at least 6 months. Those

invited to participate will fall into three categories as described below:

(1) Normal Control Individuals would be those individuals that have

had no muscle pain or weakness while taking statins.

(2) Severely Affected Individuals would be those who suffer

incapacitating muscle pain, cramps or weakness that leads to

disability temporarily while taking statin drugs, or persistently

after drug therapy has been discontinued. In addition, any

participant who has had any of the following abnormal test results (if

known):

* The observation of " coca-cola " colored urine

* Abnormal elevation of a blood substance called " creatine kinase " or

CK or CPK

* Abnormal EMG (electromyogram). This test is performed by a

neurologist who places a needle in various muscles and electrically

stimulates the muscles. You may already have had muscle biopsy

studies performed.

(3) Mildly Affected Individuals are those who have noted mild muscle

pain, cramps or weakness that is bearable without discontinuing statin

therapy.

There is no cost or payment to you for participation in this study.

The benefits to you will be the possible provision of risk factor

information about side effects from these medications that may help

with your future medical care.

*Please note that participants will be responsible for the collection

and shipment of a blood sample to our laboratory, as well as the

completion of consent forms and a medical questionnaire. Costs related

to blood collection and shipping will be reimbursed to you.*

If you would like to participate in the Statin Study, please call

Kern at 716-829-2695 on Tuesday through Friday or leave a

message for a call back.

The study protocol has been approved by the Health Sciences

Institutional Review Board of The University at Buffalo

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