Coenzyme Q10 An Independent Predictor of Mortality in CHF

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Coenzyme Q10

- An Independent Predictor of Mortality in Chronic Heart Failure

Objectives: The aim of this study was to investigate the relationship

between plasma coenzyme Q10 (CoQ10) and survival in patients with

chronic heart failure (CHF).

Background: Patients with CHF have low plasma concentrations of CoQ10,

an essential cofactor for mitochondrial electron transport and

myocardial energy supply. Additionally, low plasma total cholesterol

(TC) concentrations have been associated with higher mortality in

heart failure. Plasma CoQ10 is closely associated with low-density

lipoprotein cholesterol (LDL-C), which might contribute to this

association. Therefore we tested the hypothesis that plasma CoQ10 is a

predictor of total mortality in CHF and could explain this association.

Methods: Plasma samples from 236 patients admitted to the hospital

with CHF, with a median (range) duration of follow-up of 2.69 (0.12 to

5.75) years, were assayed for LDL-C, TC, and total CoQ10.

Results: Median age at admission was 77 years. Median (range) CoQ10

concentration was 0.68 (0.18 to 1.75) µmol/l. The optimal CoQ10

concentration for prediction of mortality (established with

receiver-operator characteristic [ROC] curves) was 0.73 µmol/l.

Multivariable analysis allowing for effects of standard predictors of

survival—including age at admission, gender, previous myocardial

infarction, N-terminal peptide of B-type natriuretic peptide, and

estimated glomerular filtration rate (modification of diet in renal

disease)—indicated CoQ10 was an independent predictor of survival,

whether dichotomized at the ROC curve cut-point (hazard ratio

---

:

2.0; 95% confidence interval [CI]: 1.2 to 3.3) or the median (HR: 1.6;

95% CI: 1.0 to 2.6).

Conclusions: Plasma CoQ10 concentration was an independent predictor

of mortality in this cohort. The CoQ10 deficiency might be detrimental

to the long-term prognosis of CHF, and there is a rationale for

controlled intervention studies with CoQ10.

Source:

http://content.onlinejacc.org/cgi/content/abstract/52/18/1435

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