Fwd: HIV Treatment Bulletin [HTB] Volume 9 Number 11/12, November/December 2008

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Dear Subscriber,

Attached to this email is the November & December 2008 issue of HIV Treatment Bulletin [HTB].

This issue includes as a supplement, the November 2008, “Guide to HIV, Pregnancy and Women’s Healthâ€, which will be send in a separate email in the next couple of days.

This issue includes articles on;

STOP PRESS: i-Base appeal (see page 2 and 41)

EDITORIAL & i-BASE APPEAL

CONFERENCE REPORTS

48th Annual International Conference on Antimicrobial Agents and Chemotherapy (ICAAC)

• Introduction

ICAAC: PREGNANCY & MTCT

• Antiretroviral Pregnancy Registry finds no increase in congenital anomalies with exposure to tenofovir

• No association between maternal antiretrovirals in pregnancy and congenital anomalies

• Pharmacokinetics of saquinavir/ritonavir in pregnancy

• Course of labour in pregnant HIV-positive women with no contraindication for vaginal delivery

• Four weeks of antiretroviral prophylaxis is sufficient for HIV exposed infants

ICAAC: WOMEN’S HEALTH

• HAART suppresses genital tract HIV shedding in HIV/HSV coinfected women

• Efavirenz significantly reduces levels of some oral contraceptives

ICAAC: PAEDIATRIC CARE

• Lack of efficacy of isoniazid (INH) prophylaxis and PK evaluation in South African infants

• 48-week data for darunavir/ritonavir (DRV/r) in treatment experienced children and adolescents

• Greater lipodystrophy risk in older US children with low viral load

ICAAC: ANTIRETROVIRALS

• Studies of pipeline drugs: RDEA806, PRO140, beviramat, elvucitabine

• Maraviroc trial results reanalysed using more sensitive CCR5 tropism test

Other antiretroviral studies at ICAAC:

- Early HAART may improve survival

- Raltegravir in treatment-naïve patients

- Darunavir is comparable to lopinavir in treatment-naïve patients

- Atazanavir is comparable to lopinavir in treatment-naïve patients

ICAAC: SIDE EFFECTS & COMPLICATIONS

• High rate of rash in HIV-negative volunteers combining raltegravir and darunavir

• Bone loss in SMART study

• Parathyroid hormone and vitamin D levels in patients using tenofovir

• Haemoglobin A1c (HbA1c) may underestimate glycaemia in patients with diabetes on HIV therapy

• Statin use in HIV-positive patients

• Non alcoholic fatty liver disease (NAFLD) is common among HIV-positive patients

ICAAC: TRANSMISSION

• HIV reinfection reported in 10% of couples in Zambian study

ICAAC: DRUG INTERACTIONS

• Drug interaction studies with approved drugs

TREATMENT ACCESS

• FDA approval of generic ARVs

ANTIRETROVIRALS

• FDA approves new paediatric AZT dosing

• US revisions to darunavir label include once-daily indication for naïve patients

• Baseline renal insufficiency and mortality risk in HIV-positive adults in Zambia

• Inflammatory and coagulation biomarkers linked to mortality in large treatment interruption trial

OPPORTUNISTIC INFECTIONS

• Single high dose fluconazole for oropharyngeal candidiasis

(OPC) comparable to standard 14-day treatment

GUIDELINES

• BHIVA Guidelines for Immunisation of HIV-infected Adults

• IAS (USA) resistance guidelines

• 2008 European Guidelines (EACS) online

• US guidelines updated - November 2008

PREGNANCY & PMTCT

• OCTANE Trial DSMB finds ritonavir-boosted lopinavir superior to nevirapine in HIV-positive women previously exposed to single dose nevirapine

• Antiretroviral therapy in pregnant women and pregnancy outcomes in Abijan, Cote D’Ivoire

PAEDIATRIC CARE

• Antiretroviral therapy in HIV-positive children in Southern Africa

DRUG INTERACTIONS

• Key papers on methadone and ritonavir

BASIC SCIENCE & VACCINE RESEARCH

• Control of a super infecting virus in an elite controller

• Second-oldest HIV-1 sequence identified

• Why do we not yet have an HIV vaccine?

OTHER NEWS

• Nobel Prize for medicine awarded to French discoverers of HIV

• Chinese AIDS activist wins human rights prize

ON THE WEB

FUTURE MEETINGS

PUBLICATIONS AND SERVICES FROM i-BASE

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Below are direct links to the PDF Files of our most popular guides.

Introduction to combination therapy June 2008 [192 Kb]

http://www.i-base.info/pdf/guides/2008/starting-jun08.pdf

A guide to changing treatment April 2007 [160 Kb]

http://www.i-base.info/pdf/guides/2007/changingapr07.pdf

Avoiding & managing side effects May 2008 [360 Kb]

http://www.i-base.info/pdf/guides/2008/sidemay08.pdf

HIV, pregnancy & women's health July 2007 [240 Kb]

http://www.i-base.info/pdf/guides/2007/pregnancyjul07.pdf

Hepatitis C for People living with HIV May 2007 [657 Kb]

http://www.i-base.info/guides/2007/HCVmay07.pdf

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