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a single dose in 12 months can help your bones

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I wonder how much better the efficacy would be if they studied people who took it while exercising with weights and taking calcium/vit D supplements

Single-Dose Zoledronate Injection Can Treat Bone Loss Through 12 Months

One intravenous dose of zoledronate can lead to significantly improved bone density in HIV-infected patients with osteopenia or osteoporosis, benefits that can persist for at least 12 months, according to the results of a U.S. study published in the Jan. 2, 2009 issue of AIDS. The randomized, double-blinded, placebo-controlled trial of 30 patients found a mean bone density increase of 3.7% in the lumbar spine and 3.2% in the hip after 12 months among patients who received zoledronate, versus an increase of 0.7% in the lumbar spine and a decrease of 1.8% in the hip among patients who received a placebo injection. 

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