Re: Dx for Flynn - IgM levels

[Guest guest]

Rogena - my husband has an IgM deficiency but no GI problems. He was diagnosed

in 2001. Macey is also deficient in IgM but that has only happened recently and

she was born with GI problems, so I've never really related the two.

Ursula - mom to (13) and Macey (11, CVID)

http://www.primaryimmune.org

http://www.jmfworld.org

http://members.cox.net/maceyh

[Guest guest]

from Dale

Rogena, the way I understand it is that IgM primarily just functions as

a pre-cursor to IgA and IgG. I don't think anyone has discovered if it

has any other function -- but by being low -- it just means that he's

going to have a hard time keeping his IgA and IgG up to correct levels.

Too much IgM causes LOTS of problems, but as far as I know too little

IgM just lowers the amount of available IgG and IgA. My suspicion is

that he may be borderline or low-normal on his IgA and just not have

sufficient amounts to fight off infections in the mucosa. I would

think they would next check to see what his protection level is

(vaccination titers) to see if his low levels are affecting his

protection level. Obviously his clinical picture says that it is.

Sorry to hear that your little one is following in big-brother's foot

steps.

In His service,

dale

[Guest guest]

hi! I can indeed say that GI problems seem to go along with the PID issues. I

have three boys who all have PID and they all have some kind of

reflux..vomiting..diarhhea..and just stomach problems in general. Two of my

five sons actually had to have stomach surgery to stop the vomiting it was so

bad..it is crazy all the things that seem to go together. if you need any info

on stomah problems..I have deal with a wide variety of them.

nogirlsallboys <mrlbrinks@...> wrote: First of all, Dale, I am so

sorry to hear of your father's passing. I

have lost my mother recently and I can sympathize with the loss of a

parent.

I just wanted to vent. I FINALLY am getting somewhere with the drs.

regarding my " baby " , Flynn, who is 2yo. He has been through the mill

of illnesses since over a year ago. The ped kept telling me he

was " fine " and the picture of a stomping toddler. He is large for his

age at 39 1/2 in. tall and 45 lbs. His endocrine tests are all normal.

The problem has been his respiratory distress, vomiting and

constipation alternated with diahhrea. After the allergy testing came

back normal, I had to insist that they do some bloodwork to test for a

PID. I mean, come on,his 3yo brother and his father and a paternal

aunt all have deficiencies.

Well, the tests are in and he indeed has a def. It looks like a very

minor IgG def and a IgM def. So now we wait to see the immuno next

month. I am sure they can't do much for him at this time.

Does anyone know if an IgM def would contribute to his GI issues? He

suffers from vomiting, severe constipation and now more recently,

diahhrea (although I think maybe the D is from a viral infection).

I don't know much about the IgM levels. Any info would be great! He

sees a GI in January to address the motility issues.

-Rogena …Proud mom to 4 rambling boys, including:

Cole (3yo)-Selective IgA def, GERD, EED, Asthma, Dairy Allergic

Flynn (2yo) - IgG & IgM def, GERD, GI Motility Issues, Asthma

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[Guest guest]

Dale, THANK YOU for clearing up the picture a bit and putting it

into " normal " language for me! The drs language can get a bit

confusing.

Flynn's IgA is indeed within range,but I would consider it to be a

slight bit on the low side. His was 38 [20-150].

His IgM was 16 [30-180] and his IgG was 393 [400-1,200].

Since his IgG levels are just slightly off the " normal " , I can't

imagine the immuno will much for him. I am sure they will test his

titers and go from there.

Thanks again!

-Rogena …Proud mom to 4 boys, including:

Cole (3yo)-Selective IgA def, GERD, EED, Asthma, Dairy Allergic

Flynn (2yo) - IgG & IgM def, GERD, GI Motility Issues, Asthma

[Guest guest]

Dale, THANK YOU for clearing up the picture a bit and putting it

into " normal " language for me! The drs language can get a bit

confusing.

Flynn's IgA is indeed within range,but I would consider it to be a

slight bit on the low side. His was 38 [20-150].

His IgM was 16 [30-180] and his IgG was 393 [400-1,200].

Since his IgG levels are just slightly off the " normal " , I can't

imagine the immuno will much for him. I am sure they will test his

titers and go from there.

Thanks again!

-Rogena …Proud mom to 4 boys, including:

Cole (3yo)-Selective IgA def, GERD, EED, Asthma, Dairy Allergic

Flynn (2yo) - IgG & IgM def, GERD, GI Motility Issues, Asthma