Altered levels of Bcl2 and p53 in Autism/ hyperactive mouse-anti-phospholipid a

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I can't access the article, but from the title it appears to be more

validation for in Autism. (see 2nd abstract) It's also right in line

with the NIH info on autism. (immune system, genetic hotspot -DNA repair)

Synapse 2001 Dec 15;42(4):281-4 Related Articles, Books, LinkOut

Altered levels of Bcl2 and p53 proteins in parietal cortex reflect deranged

apoptotic regulation in autism.

Fatemi SH, Halt AR.

Department of Psychiatry, Division of Neuroscience Research, University of

Minnesota Medical School, Minneapolis 55455, USA. fatem002@...

PMID: 11746727 [PubMed - in process]

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Cancer Biother Radiopharm 2001 Feb;16(1):63-71 Related Articles, Books,

LinkOut

Cell cycle control in cellular homeostasis during the immune response:

interactions between TH1, TH2 cytokines, and Bcl2 and p53 molecules.

Contasta I, Pellegrini P, Berghella AM, Adorno D.

Istituto CNR di Tipizzazione Tissutale, e problemi della dialisi, P.le

Collemaggio, 67100 L'Aquila, Italia.

Cytokine regulation of lymphocyte survival may play an important role in the

control of the cell cycle during the immune response both in health and

disease. Expression of the Bcl2 gene promotes cell survival by countering

apoptosis stimuli. The p53 protein has been implicated in the control of the

cell cycle, in the synthesis and repair of DNA and in programmed cell death.

TH1 and TH2 cytokines exert a mutual cross-regulation on the precursors of

TH1- or TH2-type effector cells which are important mediators in directing

the immune system towards the appropriate response. TH1 and TH2 cytokines

have also been implicated in the modulation of the expression of cell cycle

regulator genes. Therefore, the study of the relationships between TH1 and

TH2 cytokines and Bcl2 and p53 molecules in healthy subjects could lead to a

better understanding of the physiological regulation of the immune response

and identify markers for prognostic and diagnostic indices and

biotherapeutic treatment. We determined the serum levels of cytokines (IL2,

IFN gamma, IL4, IL10, IL5, IL6, IL1 beta, TNF alpha, IL8), soluble receptors

(sIL2R, sIL6R), Bcl2-protein and p53-antibody in a group of healthy

subjects. Multivariate statistical analyses were used to study the cytokine

network relationships with Bcl2-protein and p53-antibody, as they allow a

simultaneous evaluation of all variables which reflects the physiological

situation. Our overall results suggest that relationships exist between TH1

and TH2 cytokines and the Bcl2-protein and p53-antibody in physiological

conditions. This information could now be used in experimental studies to

create diagnostic and prognostic indices for the monitoring of health and

disease.

PMID: 11279799 [PubMed - indexed for MEDLINE]

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Lupus 2001;10(7):496-9 Related Articles, Books, LinkOut

Hyperactivity in a mouse model of the antiphospholipid syndrome.

Katzav A, Pick CG, Korczyn AD, Oest E, Blank M, Shoenfeld Y, Chapman J.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel

Aviv, Israel.

In the antiphospholipid syndrome (APS), antibodies to a complex of

phospholipids and beta2-glycoprotein I (beta2-GPI) are associated with

recurrent thromboembolic events, spontaneous abortions, thrombocytopenia and

central nervous system (CNS) disturbances. Animals immunized with beta2-GPI

develop the systemic manifestations of APS but the involvement of the (CNS)

in these animals has not been studied. The objective of the present study

was to examine mice with induced experimental APS for behavioral changes.

Female Balb/C mice were immunized once with beta2-GPI in complete Freund's

adjuvant (CFA) or with CFA alone. Four months after immunization the mice

were tested in the staircase apparatus and the following two variables were

measured: (1) number of rears: and (2) number of stairs climbed by the mice.

Immunization with beta2-GPI resulted in elevated levels of circulating

anti-negatively charged phospholipids and anti-beta2-GPI antibodies. The APS

mice exhibited hyperactive behavior as reflected by more frequent rears (P <

0.023) and higher number of stairs climbed (P < 0.019) by the mice in 3 min.

This simple test demonstrated that experimental APS animals are

significantly hyperactive and may serve as a marker for CNS involvement in

this model.

PMID: 11480848 [PubMed - indexed for MEDLINE]

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