Re: White Blood Cell count.

[Guest guest]

Dear Jamy,

My white count stays close to 2,000 consistently. I have to be careful also to

stay away from public areas. This Christmas season was very tough. I do have a

cold now but hopefully with lots of TLC and fluids I will get over it quickly.

If it's not better in a couple days I will see the doctor for antibiotics.

Your dad can expect to have low counts. Gleevec is strong medicine so it will do

that to the GOOD numbers also. 

I know others will add their experiences too.  I am not on Gleevec right now

but I was back in 2004 when I was first diagnosed. I am now in a clinical trial

for AP24534.

God BLess you and your Dad and a Happy New Year,

Jackie S. 

From: Jamshid <jamshid98@...>

Subject: [ ] White Blood Cell count.

Date: Tuesday, December 29, 2009, 10:48 AM

 

Dear All,

My father has Diagonsed with CML on 3 months back, since

then he is on ‘Gleevec 400Mg’ . His WBC (white

blood cell) count has been comes to normal ever since he started Gleevec and we

used to do blood examination every week

and inform the report to the doctor. Last week when we did blood

examination, found that WBC count has been come down to 3900. Below

Normal. (Normal is 4500 – 11,000).

Platelet count and Haemoglobin is

normal. Doctor reduced the Gleevec to 300mg last week. But when we examined

yesterday the WBC count

has been again came down to 3600. When I asked the doctor he said, coz of age

ther

might be some limitations and he cannot reduce from 300mg Gleevc coz it will

not give any progress in

CML. Dr found that he has congestion in

chest and gave one cough syrup and asked to wear mask and avoid visting public

places and restricted visitors. He is a

heart patient too and gone through angioplasty 7 years back. Today he was

saying he has pain from the left side of chest and its not from the center of

the heart area. Doctor saying its because of muscle cramp and no need to worry.

Has anyone had this WBC count drastic come down occurred? And

what are the precaustions we need to take care. I heard that if WBC is low

there are more chances to effect neumonia and other diseases.

Your opions will be highy supportive.

Regards,

Jamy

[Guest guest]

Jackie,

If you don't mind me asking..what is the clinical trial you are on and where are

you doing that?  We are always looking for options as everyone is.

Thanks!!

Mackenzie

Missouri

From: Jamshid <jamshid98 (DOT) com>

Subject: [ ] White Blood Cell count.

groups (DOT) com

Date: Tuesday, December 29, 2009, 10:48 AM

 

Dear All,

My father has Diagonsed with CML on 3 months back, since

then he is on ‘Gleevec 400Mg’ . His WBC (white

blood cell) count has been comes to normal ever since he started Gleevec and we

used to do blood examination every week

and inform the report to the doctor. Last week when we did blood

examination, found that WBC count has been come down to 3900. Below

Normal. (Normal is 4500 – 11,000).

Platelet count and Haemoglobin is

normal. Doctor reduced the Gleevec to 300mg last week. But when we examined

yesterday the WBC count

has been again came down to 3600. When I asked the doctor he said, coz of age

ther

might be some limitations and he cannot reduce from 300mg Gleevc coz it will not

give any progress in

CML. Dr found that he has congestion in

chest and gave one cough syrup and asked to wear mask and avoid visting public

places and restricted visitors. He is a

heart patient too and gone through angioplasty 7 years back. Today he was

saying he has pain from the left side of chest and its not from the center of

the heart area. Doctor saying its because of muscle cramp and no need to worry.

Has anyone had this WBC count drastic come down occurred? And

what are the precaustions we need to take care. I heard that if WBC is low

there are more chances to effect neumonia and other diseases.

Your opions will be highy supportive.

Regards,

Jamy

[Guest guest]

Hi Jamy,

It's very normal to see a patient's white count drop during Gleevec therapy.

Some people will continue to have low counts while others will rebound to normal

levels once the marrow has recovered from the shock.

Your Dad's white count isn't really what is important, it's his ANC or Absolute

Neutrophil Count. This should ideally be above 1.0. Do you know what your

Dad's Neutrophil count is? If it's over 1.0 he has nothing to worry about. If

it's lower then 1.0, he needs to be careful because he's at greater risk for

infection.

The doctor is right not to lower his dose below 300mg as it would put him at

risk for developing a resistance to the drug.

Hope that helps a bit,

Tracey

>

> Dear All,

> My father has Diagonsed with CML on 3 months back, since

> then he is on ‘Gleevec 400Mg’ . His WBC (white

> blood cell) count has been comes to normal ever since he started Gleevec and

we

> used to do blood examination every week

> and inform the report to the doctor. Last week when we did blood

> examination, found that WBC count has been come down to 3900. Below

> Normal. (Normal is 4500 †" 11,000).

> Platelet count and Haemoglobin is

> normal. Doctor reduced the Gleevec to 300mg last week. But when we

examined yesterday the WBC count

> has been again came down to 3600. When I asked the doctor he said, coz of age

ther

> might be some limitations and he cannot reduce from 300mg Gleevc coz it will

not give any progress in

> CML. Dr found that he has congestion in

> chest and gave one cough syrup and asked to wear mask and avoid visting public

> places and restricted visitors. He is a

> heart patient too and gone through angioplasty 7 years back. Today he was

> saying he has pain from the left side of chest and its not from the center of

> the heart area. Doctor saying its because of muscle cramp and no need to

worry.

> Has anyone had this WBC count drastic come down occurred? And

> what are the precaustions we need to take care. I heard that if WBC is low

> there are more chances to effect neumonia and other diseases.

> Your opions will be highy supportive.

>

> Regards,

> Jamy

>

>

>

>

>

[Guest guest]

Hi Tracey,

I asked my dad about the neutrophil count, mentioned on the report is Neutrophil

-- 42 ...( Normal range is 40 - 75) .. is it normal?

Regards,

Jamy

________________________________

From: traceyincanada <traceyincanada@...>

Sent: Wed, December 30, 2009 12:13:34 AM

Subject: [ ] Re: White Blood Cell count.

Hi Jamy,

It's very normal to see a patient's white count drop during Gleevec therapy.

Some people will continue to have low counts while others will rebound to normal

levels once the marrow has recovered from the shock.

Your Dad's white count isn't really what is important, it's his ANC or Absolute

Neutrophil Count. This should ideally be above 1.0. Do you know what your

Dad's Neutrophil count is? If it's over 1.0 he has nothing to worry about. If

it's lower then 1.0, he needs to be careful because he's at greater risk for

infection.

The doctor is right not to lower his dose below 300mg as it would put him at

risk for developing a resistance to the drug.

Hope that helps a bit,

Tracey

>

> Dear All,

> My father has Diagonsed with CML on 3 months back, since

> then he is on ‘Gleevec 400Mg’ . His WBC (white

> blood cell) count has been comes to normal ever since he started Gleevec and

we

> used to do blood examination every week

> and inform the report to the doctor. Last week when we did blood

> examination, found that WBC count has been come down to 3900. Below

> Normal. (Normal is 4500 †" 11,000).

> Platelet count and Haemoglobin is

> normal. Doctor reduced the Gleevec to 300mg last week. But when we

examined yesterday the WBC count

> has been again came down to 3600. When I asked the doctor he said, coz of age

ther

> might be some limitations and he cannot reduce from 300mg Gleevc coz it will

not give any progress in

> CML. Dr found that he has congestion in

> chest and gave one cough syrup and asked to wear mask and avoid visting public

> places and restricted visitors. He is a

> heart patient too and gone through angioplasty 7 years back. Today he was

> saying he has pain from the left side of chest and its not from the center of

> the heart area. Doctor saying its because of muscle cramp and no need to

worry.

> Has anyone had this WBC count drastic come down occurred? And

> what are the precaustions we need to take care. I heard that if WBC is low

> there are more chances to effect neumonia and other diseases.

> Your opions will be highy supportive.

>

> Regards,

> Jamy

>

>

>

>

>

[Guest guest]

Hi Jamy,

That sounds like the neutrophil percentage not the absolute neutrophil count.

If the absolute count isn't on the report, you can calculate it by multiplying

the WBC by the Neutrophil percentage.

So if his WBC was 3.6 (this is the same as 3600) and his neutrophil percentage

was 42 (this would be 0.42 in whole numbers), that would make his absolute

neutrophil count 1.5. Like I said before, anything over 1.0 is considered safe

so he's in a good place with numbers like this. Not to worry.

Hope that helps,

Tracey

> >

> > Dear All,

> > My father has Diagonsed with CML on 3 months back, since

> > then he is on ‘Gleevec 400Mg’ . His WBC (white

> > blood cell) count has been comes to normal ever since he started Gleevec and

we

> > used to do blood examination every week

> > and inform the report to the doctor. Last week when we did blood

> > examination, found that WBC count has been come down to 3900. Below

> > Normal. (Normal is 4500 †" 11,000).

> > Platelet count and Haemoglobin is

> > normal. Doctor reduced the Gleevec to 300mg last week. But when we

examined yesterday the WBC count

> > has been again came down to 3600. When I asked the doctor he said, coz of

age ther

> > might be some limitations and he cannot reduce from 300mg Gleevc coz it

will not give any progress in

> > CML. Dr found that he has congestion in

> > chest and gave one cough syrup and asked to wear mask and avoid visting

public

> > places and restricted visitors. He is a

> > heart patient too and gone through angioplasty 7 years back. Today he was

> > saying he has pain from the left side of chest and its not from the center

of

> > the heart area. Doctor saying its because of muscle cramp and no need to

worry.

> > Has anyone had this WBC count drastic come down occurred? And

> > what are the precaustions we need to take care. I heard that if WBC is low

> > there are more chances to effect neumonia and other diseases.

> > Your opions will be highy supportive.

> >

> > Regards,

> > Jamy

> >

> >

> >

> >

> >