Re: 6 week update on Ariad

[Guest guest]

Hi Hans, well, that's a pretty cool Christmas gift, congratulations!!  Three

cheers for Ariad!!!

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

o2/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

#840 Zavie's Zero Club

From: Hans <hansl@...>

Subject: [ ] 6 week update on Ariad

Date: Monday, December 28, 2009, 1:43 AM

 

Hi all,

My dr. did an unscheduled PCR of the blood (I think he was curious to see if

there was anything going on), and I got the results a few days before Christmas.

It showed that I went from 50 to 4.4 on International scale and 4 to 0.6 on

*other* scale (I believe it's the older standard). Either way, it's over a 1 log

reduction in 6 weeks. It's encouraging, I remain on 60 mg dosage and doing ok

there with minor side effects. Platelets dipped below 50 for a short period, but

came back up on their own.

So for those with T315 mutation, there is hope out there. I know Beths great

results have given all of us hope for a new choice available to all soon.

Hans

[Guest guest]

Hans

 

Great news!   Continued progress and success!

 

Happy New Year!

From: Hans <hansl@...>

Subject: [ ] 6 week update on Ariad

Date: Monday, December 28, 2009, 1:43 AM

 

Hi all,

My dr. did an unscheduled PCR of the blood (I think he was curious to see if

there was anything going on), and I got the results a few days before Christmas.

It showed that I went from 50 to 4.4 on International scale and 4 to 0.6 on

*other* scale (I believe it's the older standard). Either way, it's over a 1 log

reduction in 6 weeks. It's encouraging, I remain on 60 mg dosage and doing ok

there with minor side effects. Platelets dipped below 50 for a short period, but

came back up on their own.

So for those with T315 mutation, there is hope out there. I know Beths great

results have given all of us hope for a new choice available to all soon.

Hans

[Guest guest]

>

> Hi all,

>

> My dr. did an unscheduled PCR of the blood (I think he was curious to see if

there was anything going on), and I got the results a few days before Christmas.

>

> It showed that I went from 50 to 4.4 on International scale and 4 to 0.6 on

*other* scale (I believe it's the older standard). Either way, it's over a 1 log

reduction in 6 weeks. It's encouraging, I remain on 60 mg dosage and doing ok

there with minor side effects. Platelets dipped below 50 for a short period, but

came back up on their own.

________________________

Hi Hans,

That is another really spectacular Ariad result.....more than a one log

reduction in 6 weeks!! Looks like the T315I mutation has met it's match with

this drug. Congrats to you.

C.

[Guest guest]

Dear Hans: I love to hear news like this, and thats why we post our results.

It gives people encouragement and faith in what is being done in the field for

CML. God Bless You With Continued Progress.

A.

>

> Hi all,

>

> My dr. did an unscheduled PCR of the blood (I think he was curious to see if

there was anything going on), and I got the results a few days before Christmas.

>

> It showed that I went from 50 to 4.4 on International scale and 4 to 0.6 on

*other* scale (I believe it's the older standard). Either way, it's over a 1 log

reduction in 6 weeks. It's encouraging, I remain on 60 mg dosage and doing ok

there with minor side effects. Platelets dipped below 50 for a short period, but

came back up on their own.

>

> So for those with T315 mutation, there is hope out there. I know Beths great

results have given all of us hope for a new choice available to all soon.

>

> Hans

>

[Guest guest]

Hans,

Congratulations thanks for sharing such wonderful news and brings much hope to

others

Happy New Year

Anita

________________________________

>

> Hi all,

>

> My dr. did an unscheduled PCR of the blood (I think he was curious to see if

there was anything going on), and I got the results a few days before Christmas.

>

> It showed that I went from 50 to 4.4 on International scale and 4 to 0.6 on

*other* scale (I believe it's the older standard). Either way, it's over a 1 log

reduction in 6 weeks. It's encouraging, I remain on 60 mg dosage and doing ok

there with minor side effects. Platelets dipped below 50 for a short period, but

came back up on their own.

>

> So for those with T315 mutation, there is hope out there. I know Beths great

results have given all of us hope for a new choice available to all soon.

>

> Hans

>