RE: Re: for Josie - burning in the sun

[Guest guest]

Thank you Tracey

When I was on Gleevec I was very pale but not so on Tasigna. Does Tasigna

not have that enzyme???

Sharon

_____

From: [mailto: ] On Behalf Of

traceyincanada

Sent: Wednesday, January 20, 2010 6:37 PM

Subject: [ ] Re: for Josie - burning in the sun

>

> Josie, my Onc. explained that the same gene that makes CML also governs

the melanin in your skin and hair

******************************************

I think you may have misunderstood the explanation Cheryl. The gene that

causes CML (BCR/ABL) has nothing to do with skin. Gleevec however has a

secondary effect by inhibiting an enzyme called c-kit which regulates the

production of melanin. With melanin being in short supply, skin colour

becomes pale. This effect is due to the drug, not the disease.

Tracey

[Guest guest]

Hi Guys,

I can tell you I am very brown here in sunny warm Australia!

Regards,

From: [mailto: ] On Behalf Of

traceyincanada

Sent: Thursday, 21 January 2010 1:56 PM

Subject: [ ] Re: for Josie - burning in the sun

Hi Sharon,

Tasigna does inhibit the same enzyme but it's possible that it has lesser of

an effect on it than Gleevec did. I think I've heard others say that their

skin was not as dramatically affected by Tasigna as it was with Gleevec.

Tracey

> >

> > Josie, my Onc. explained that the same gene that makes CML also governs

> the melanin in your skin and hair

> ******************************************

>

> I think you may have misunderstood the explanation Cheryl. The gene that

> causes CML (BCR/ABL) has nothing to do with skin. Gleevec however has a

> secondary effect by inhibiting an enzyme called c-kit which regulates the

> production of melanin. With melanin being in short supply, skin colour

> becomes pale. This effect is due to the drug, not the disease.

>

> Tracey

>

>

>

>

>

>

[Guest guest]

PS I’m on Tasigna

Regards,

From: [mailto: ] On Behalf Of

Malseed

Sent: Thursday, 21 January 2010 6:28 PM

Subject: RE: [ ] Re: for Josie - burning in the sun

Hi Guys,

I can tell you I am very brown here in sunny warm Australia!

Regards,

From: <mailto:%40>

[mailto: <mailto:%40> ] On Behalf Of

traceyincanada

Sent: Thursday, 21 January 2010 1:56 PM

<mailto:%40>

Subject: [ ] Re: for Josie - burning in the sun

Hi Sharon,

Tasigna does inhibit the same enzyme but it's possible that it has lesser of

an effect on it than Gleevec did. I think I've heard others say that their

skin was not as dramatically affected by Tasigna as it was with Gleevec.

Tracey

> >

> > Josie, my Onc. explained that the same gene that makes CML also governs

> the melanin in your skin and hair

> ******************************************

>

> I think you may have misunderstood the explanation Cheryl. The gene that

> causes CML (BCR/ABL) has nothing to do with skin. Gleevec however has a

> secondary effect by inhibiting an enzyme called c-kit which regulates the

> production of melanin. With melanin being in short supply, skin colour

> becomes pale. This effect is due to the drug, not the disease.

>

> Tracey

>

>

>

>

>

>

[Guest guest]

And although it is raining cats and dogs here in Northern Calif.. in the

summer I tan beautifully and I happen to be a sun worshipper!!!! I love

being tanned. Born in Hawaii that’s why.

And I am on Tasigna too

Sharon

_____

From: [mailto: ] On Behalf Of

Malseed

Sent: Wednesday, January 20, 2010 11:30 PM

Subject: RE: [ ] Re: for Josie - burning in the sun

PS I’m on Tasigna

Regards,

From: groups (DOT) <mailto:%40> com

[mailto:groups (DOT) <mailto:%40> com] On Behalf Of

Malseed

Sent: Thursday, 21 January 2010 6:28 PM

groups (DOT) <mailto:%40> com

Subject: RE: [ ] Re: for Josie - burning in the sun

Hi Guys,

I can tell you I am very brown here in sunny warm Australia!

Regards,

From: groups (DOT) <mailto:%40> com

<mailto:%40>

[mailto:groups (DOT) <mailto:%40> com

<mailto:%40> ] On Behalf Of

traceyincanada

Sent: Thursday, 21 January 2010 1:56 PM

groups (DOT) <mailto:%40> com

<mailto:%40>

Subject: [ ] Re: for Josie - burning in the sun

Hi Sharon,

Tasigna does inhibit the same enzyme but it's possible that it has lesser of

an effect on it than Gleevec did. I think I've heard others say that their

skin was not as dramatically affected by Tasigna as it was with Gleevec.

Tracey

> >

> > Josie, my Onc. explained that the same gene that makes CML also governs

> the melanin in your skin and hair

> ******************************************

>

> I think you may have misunderstood the explanation Cheryl. The gene that

> causes CML (BCR/ABL) has nothing to do with skin. Gleevec however has a

> secondary effect by inhibiting an enzyme called c-kit which regulates the

> production of melanin. With melanin being in short supply, skin colour

> becomes pale. This effect is due to the drug, not the disease.

>

> Tracey

>

>

>

>

>

>