Re: Another set of Ariad results

[Guest guest]

O!!! YIPPEEE!!!

Number 1303 in the Zero Club

Zavie

What a great result! This reminds me of the excitement generated by STI571

(now Gleevec) in the early day when patients first tried the drug.

Thanks for sharing and pioneering.

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

Tel in FL: 561-429-5507

_____

From: [mailto: ] On Behalf Of Hans

Sent: February-07-10 2:23 AM

Subject: [ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a

leap of faith and managed to get enrolled at OHSU. I am on 60 mg still with

minimal side effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

Hans, I am so happy for you, that is great, truly great!!

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

11/2009 PCR 0.034

#840 Zavie's Zero Club

From: Hans <hansl@...>

Subject: [ ] Another set of Ariad results

Date: Sunday, February 7, 2010, 2:22 AM

 

I just got my 3 month results back from being on the Ariad study. Just

some background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a leap of

faith and managed to get enrolled at OHSU. I am on 60 mg still with minimal side

effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

Dear Hans,

That is awesome news! You are paving the way for the rest of us. I hope that

some day soon I can increase my dosage. There is no talk of it yet, and Im not

sure if its possible since I decreased due to low numbers. Time will tell.

Never loosing HOPE.

God Bless,

Jackie S.

________________________________

From: Hans <hansl@...>

Sent: Sun, February 7, 2010 1:22:53 AM

Subject: [ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a leap of

faith and managed to get enrolled at OHSU. I am on 60 mg still with minimal side

effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

Wow Hans--congratulations! This is great news. It sounds like Ariad

is the drug we were missing. I'm just so happy to hear this.

Best wishes,

Dorothy

On Feb 7, 2010, at 2:22 AM, Hans wrote:

> I just got my 3 month results back from being on the Ariad study.

> Just some background. Diagnosed in Dec 08, Gleevec and Sprycel

> didn't give me any cytogenetic response, and minimal PCR. After 3

> months on Sprycel, we ran the mutation test and found that I had

> T315 mutation.

>

> As luck had it, I had read Beth's comment about the trial, and we

> took a leap of faith and managed to get enrolled at OHSU. I am on 60

> mg still with minimal side effects, although current dosage is 45

> for newly enrollee's.

>

> Here are my numbers after 3 months:

>

> Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

> Fish: Start of Trial: 112/200 Current: 0/200

> qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

>

> That is a 2 log reduction in 3 months.

>

> So I am officially in Complete Cytogenetic Response.

>

> Zavie - Does that mean I qualify to get a number ?

>

> Hans

>

> PS. As my 3 year old would say, 'today was a good day'.....

>

>

> __._,_._

[Guest guest]

Wow , congratulations and believe me I understand how you feel !

I'm very happy for you .

Thank you to sharing that and remember me the time of this kind of news .

Emile

#527 Zavie's Club

[ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

Switch to: Text-Only, Daily Digest . Unsubscribe . Terms of Use.

[Guest guest]

Hans i am sooo happy for you. Praying you coNtinue to do well. God Bless all

amanda

[ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a leap of

faith and managed to get enrolled at OHSU. I am on 60 mg still with minimal side

effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

That is truly wonderful news!! Congratulations!

________________________________

From: Hans <hansl@...>

Sent: Sat, February 6, 2010 11:22:53 PM

Subject: [ ] Another set of Ariad results

 

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a leap of

faith and managed to get enrolled at OHSU. I am on 60 mg still with minimal side

effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

Congratulations that is great news. So happy for you

Anita

________________________________

From: Lomsdalen <llomsdalen@...>

Sent: Sun, February 7, 2010 11:48:26 AM

Subject: Re: [ ] Another set of Ariad results

That is truly wonderful news!! Congratulations!

____________ _________ _________ __

From: Hans <hanslmicrosoft (DOT) com>

groups (DOT) com

Sent: Sat, February 6, 2010 11:22:53 PM

Subject: [ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a leap of

faith and managed to get enrolled at OHSU. I am on 60 mg still with minimal side

effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

Hi Hans, excellent news

T

Dxd 2/03

CCR 7/03

3 log reduction

300 mg Gleevec

Zavie's Club

#761 nt sure

Sent from my Verizon Wireless BlackBerry

[ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a leap of

faith and managed to get enrolled at OHSU. I am on 60 mg still with minimal side

effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

It's # 764

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

Tel in FL: 561-429-5507

_____

From: [mailto: ] On Behalf Of

mtadros9@...

Sent: February-07-10 5:43 PM

Subject: Re: [ ] Another set of Ariad results

Hi Hans, excellent news

T

Dxd 2/03

CCR 7/03

3 log reduction

300 mg Gleevec

Zavie's Club

#761 nt sure

Sent from my Verizon Wireless BlackBerry

[ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a

leap of faith and managed to get enrolled at OHSU. I am on 60 mg still with

minimal side effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....

[Guest guest]

Thank you Zavie

Sent from my Verizon Wireless BlackBerry

[ ] Another set of Ariad results

I just got my 3 month results back from being on the Ariad study. Just some

background. Diagnosed in Dec 08, Gleevec and Sprycel didn't give me any

cytogenetic response, and minimal PCR. After 3 months on Sprycel, we ran the

mutation test and found that I had T315 mutation.

As luck had it, I had read Beth's comment about the trial, and we took a

leap of faith and managed to get enrolled at OHSU. I am on 60 mg still with

minimal side effects, although current dosage is 45 for newly enrollee's.

Here are my numbers after 3 months:

Metaphase Cytogenetic: Start of Trial: 17/20 Current: 0/20

Fish: Start of Trial: 112/200 Current: 0/200

qPCR: Start of Trial: 50% (is) Current: 0.4% (is)

That is a 2 log reduction in 3 months.

So I am officially in Complete Cytogenetic Response.

Zavie - Does that mean I qualify to get a number ?

Hans

PS. As my 3 year old would say, 'today was a good day'.....