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Cancer web cam

http://www.medicalnewstoday.com/info/cancer-oncology/whatiscancer.php

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New Cancer Pathways discovered

Case Western Reserve University researchers, from the School of Medicine's

Department of Nutrition, discovered two new metabolic pathways by which products

of lipid peroxidation and some drugs of abuse, known as 4-hydroxyacids, are

metabolized. The pathways were identified by a combination of metabolomics and

mass isotopomer analysis. The findings shed new light on the mechanism of action

of the drug of abuse gamma-hydroxybutyrate, also known as " the date rape drug. "

The manuscript published in the November 27th issue of the Journal of Biological

Chemistry was named a " Paper of the Week. " Such papers are chosen from the top

one percent of all articles submitted to the prestigious peer-reviewed journal.

This type of rare breakthrough sets the ground work for future discoveries.

" This work was supported by a RoadMap grant from the National Institutes of

Health, a grant from the National Institute of Environment Health Sciences, as

well as by a grant from the Cleveland Mt. Sinai Health Care Foundation. The

RoadMap grant funded the development of metabolomics at Case Western Reserve, as

well as the acquisition of a top-of-the-line mass spectrometer. This instrument

allowed this and multiple other studies to be conducted. The RoadMap initiative

allowed a quantum jump in the development of metabolic research at the School of

Medicine.

" Our finding will lead to studies that will increase the understanding of

metabolic disturbances that occur during oxidative stress. The latter is part of

the pathology of heart attacks, stroke, diabetes and inflammation, " says

Guo-Fang Zhang, Ph.D., Research Associate in the Department of Nutrition at Case

Western Reserve School of Medicine. " We hope that the upcoming studies will lead

to the design of new treatments that minimize the effects of oxidative stress. "

" Paving a Catabolic Highway, " an editorial about this landmark study concluded,

" Overall, this study represents an exemplary prototype for any projects that aim

to identify incomplete or unknown metabolic pathways. "

" A combined effort of Case Western Reserve University and the Mt. Sinai Health

Care Foundation since 1990 has lead to the building of this department's

research program and the conception of this groundbreaking finding, " says Henri

Brunengraber, M.D., Ph.D., Senior Author, Professor, and Chair of the Department

of Nutrition. " We plan to expand this project in close collaboration with

P. Tochtrop, Ph.D., Assistant Professor in the Department of Chemistry.

Dr. Tochtrop and his group have synthesized a number of carbon 13-labeled

compounds which allowed the unraveling of the steps of the new pathways we

discovered " .

" Dr. Brunengraber was recently named the inaugural Mt. Sinai Auxiliary

Commemorative Chair in Nutrition Research. The professorship was made possible

by a grant from the Mt. Sinai Health Care Foundation to commemorate the Mt.

Sinai Community Partners, formerly the Mt. Sinai Auxiliary. " Source:

Studeny, Case Western Reserve University

http://www.medicalnewstoday.com/articles/173146.php

FYI,

Lottie Duthu