Re: for Josie - burning in the sun

[Guest guest]

????

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From: [mailto: ] On Behalf Of

thornton_cheryl

Sent: Wednesday, January 20, 2010 12:47 PM

Subject: [ ] for Josie - burning in the sun

Josie, my Onc. explained that the same gene that makes CML also governs the

melanin in your skin and hair and so I was too wear very high SPF in the sun

as there is a greater risk for skin cancer...and that's why CML patients

look pasty white and go grey...

[Guest guest]

>

> Josie, my Onc. explained that the same gene that makes CML also governs the

melanin in your skin and hair

******************************************

I think you may have misunderstood the explanation Cheryl. The gene that causes

CML (BCR/ABL) has nothing to do with skin. Gleevec however has a secondary

effect by inhibiting an enzyme called c-kit which regulates the production of

melanin. With melanin being in short supply, skin colour becomes pale. This

effect is due to the drug, not the disease.

Tracey

[Guest guest]

Hi Sharon,

Tasigna does inhibit the same enzyme but it's possible that it has lesser of an

effect on it than Gleevec did. I think I've heard others say that their skin

was not as dramatically affected by Tasigna as it was with Gleevec.

Tracey

> >

> > Josie, my Onc. explained that the same gene that makes CML also governs

> the melanin in your skin and hair

> ******************************************

>

> I think you may have misunderstood the explanation Cheryl. The gene that

> causes CML (BCR/ABL) has nothing to do with skin. Gleevec however has a

> secondary effect by inhibiting an enzyme called c-kit which regulates the

> production of melanin. With melanin being in short supply, skin colour

> becomes pale. This effect is due to the drug, not the disease.

>

> Tracey

>

>

>

>

>

>

[Guest guest]

Tracey,

I was very pale also when on Gleevec and not so much now that I am on

Sprycel..I do get a red butterfly shape thing going over the nose and checks at

some point during the day/night.My Rhuemy just dx me with Fibro and is checking

for Lupus and hypothyroid..I see him next week for all the test results..I am

doing so much better on Sprycel.I am actually exercising again and off 1 of my

pain pills..

Thanks

SharonS

>

> Hi Sharon,

>

> Tasigna does inhibit the same enzyme but it's possible that it has lesser of

an effect on it than Gleevec did. I think I've heard others say that their skin

was not as dramatically affected by Tasigna as it was with Gleevec.

>

> Tracey

>