Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 I agree with Jerry, well said. Patty Re: [ ] Low platelets lori..... I wonder why you were taken off the meds in the first place as the disease is chronic and progressive. I can see perhaps trying to go without the prednisone but the disease is incurable and coming of the immuno would seem to encourage the immune system to start doing it's nasty work again. LFTs are a misnomer as they do not measure how your liver is actually functioning. You have had a biopsy, perhaps you need another to see how damaged your liver is. An enlarged spleen as well as an enlarged liver can be palpitated besides scanned. What other indications are on your blood tests,,,,serum albumin is one indicator of damage as is prothrombin-time and to a much lesser degree serum billirubin.. Another thing you might look into is a liver specialist (hepatologist)..... In order to actually get a transplant your liver would have to be damaged to such a degree that death is the only conclusion...before you get to that stage you would most likely suffer from other conditions such as ascites and edema,bleeding varices and possibly hepatic encephalopathy. If your liver is continuing to be damaged by AIH I would think it wise to go back on meds. I think prednisone is used sometimes in order to maintain platelet levels. There are other reasons for low platelet counts than the liver disease (of course none of them good) How high were your prednisone dosages to cause that much damage in such a short time? I really believe you should see a liver specialist in addition to your GP. Tell us more. love jerry Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 Lori, Have you been tested for the antiphospholipid syndrome? This is an autoimmune disease which can cause low platelets, increased risk of stroke, blood clots, heart disease, and miscarriage. The blood tests for this are the lupus anticoagulant and the anticardiolipin antibodies. People with the antiphospholipid syndrome test positive for either one or both of these. It's worth asking your doc about. W Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 19, 2005 Report Share Posted December 19, 2005 I read Melatonin can help. Here's the link and an excerpt I copied and pasted. " Increased platelet counts after melatonin use have been observed in patients with decreased platelets due to cancer therapies (several studies reported by the same author) (115; 113; 120; 121; 122; 130; 131), and stimulation of platelet production (thrombopoeisis) has been suggested but not clearly demonstrated. Although these early reported benefits are promising, high-quality controlled trials are necessary before a clear conclusion can be reached in this area. It remains unclear if melatonin safely reduces side effects of various chemotherapies without altering effectiveness. http://www.mayoclinic.com/health/melatonin/NS_patient-melatonin Gorrie wrote: > Anyone know of any suupliment or Herb that might help raise your Platelet Count. At 105, need to get a little higher! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 19, 2005 Report Share Posted December 19, 2005 This might help. www.mywaiora.com/411760 Click on Natural Cellular Defense. On the right had side click on US Patent. Another screen should open. Gorrie wrote: Anyone know of any suupliment or Herb that might help raise your Platelet Count. At 105, need to get a little higher! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 20, 2005 Report Share Posted December 20, 2005 I've been using self-hypnosis to increase my WBC and it went from 2.5 to 2.7 in one week. Date: Mon, 19 Dec 2005 From: Gorrie Subject: LOW Platelets Anyone know of any suupliment or Herb that might help raise your Platelet Count. At 105, need to get a little higher! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 22, 2005 Report Share Posted December 22, 2005 Hi Nina! Thanks for getting back to me! Maybe I should have been a little more clear!! I have had CLL for about 2 years now! My WBC has been holding the same for about a year now(which is good news). I have been taking a bunch of Chimnese herbs. Just out of no where the last 5 months though, my platelet count started going down. It has been 108 now for 4 months. Do you still suggest the same things? Thanks again! nina pavlotsky <npavlots@...> wrote: Hi, , You are talking only about platelets, and what about white blood cells, RBC. They all come from the same place, bone marrow. You need to stop the destruction with high doses of magnesium (300mg, three times/day), and vitamin B2 (benzine remover), you need selenium, organic germanium, Vitamin C. Low platelete level means toxins - heavy metals in the system. Watch your heart. These recommendations come from Dr. program. The best you can do now to be on the program. It is in the book 'The Cure for all Advanced Cancer'. Act immediately, don't waste time. Good luck Nina Gorrie wrote: Anyone know of any suupliment or Herb that might help raise your Platelet Count. At 105, need to get a little higher! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 22, 2005 Report Share Posted December 22, 2005 Hi, Yes, , I would stick with the same plan, at least I would start with high dosage of magnesium and Vit.B2. If you can afford CoQ10 in high doses for 10-12 days - 3 or 4 g depending on your weight (over 155lbs) 4g, first thing in the morning and then continue on 400mg for 4-5 days and, one day again, high dose, your body would benefit greatly from it. CoQ10 is great. I am doing this myself and will continue. But many sellers are out of it now. It comes from Japan and they expect the next shipment in January. Nina wrote: Hi Nina! Thanks for getting back to me! Maybe I should have been a little more clear!! I have had CLL for about 2 years now! My WBC has been holding the same for about a year now(which is good news). I have been taking a bunch of Chinese herbs. Just out of no where the last 5 months though, my platelet count started going down. It has been 108 now for 4 months. Do you still suggest the same things? nina pavlotsky wrote: Hi, , You are talking only about platelets, and what about white blood cells, RBC. They all come from the same place, bone marrow. You need to stop the destruction with high doses of magnesium (300mg, three times/day), and vitamin B2 (benzine remover), you need selenium, organic germanium, Vitamin C. Low platelete level means toxins - heavy metals in the system. Watch your heart. These recommendations come from Dr. program. The best you can do now to be on the program. It is in the book 'The Cure for all Advanced Cancer'. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 22, 2005 Report Share Posted December 22, 2005 , I was told to raise platelet count, try Dandelion root This man grows his own and he cannot and doesn't take money from it. He also sends off information on how to grow your own. Here is that information: Cairns, 708 Road, Woodstock, Il.60098 815-333-1626 He sends it off all around the world doesn't even charge for shipping and sends a six week supply. He says it raises platelet count. It however didn't work or doesn't work on AML. My 27 year old daughter just passed from that. CLL is different and has been known to give some wonderful results Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 22, 2005 Report Share Posted December 22, 2005 Hi , High dose chlorella (extremely high in chlorophyll) and also shark liver oil usually do a good job at raising platelets. Gubi Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2006 Report Share Posted August 10, 2006 > > my boyfriend called me at work and said his bloodwork came back low > platelets. he is on week 11 of tx. is this normal for this to happen? > im a little worried. > Hi - I have had low platelets too. Not sure when it started. My doc didn't prescribe anything for that though. I notice if I bump myself or scratch myself I bleed really easily. They have come back up to " normal " for now though. I am on Neupogen for low white count (absolute total neutrophils), so that's another 2 shots a week. My viral load was " none detected " at 24 weeks though so so far it all seems to be worth it! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2007 Report Share Posted March 30, 2007 DO your platelets rebound while on Lariam? Are they above or below 150? (Range on a standard USA test is about 200 to 400) Barb > > Chemistry and Industry > > > > February 26, 2007 > > > > Killer dialogue: when bacteria are told to do so they form biofilms > > on solid surfaces which reduce the effectiveness of antibiotics. > > Corfield looks at ways of inhibiting these instructions; > > > > Bacteria > > > > BYLINE: Corfield, > > > > SECTION: Pg. 24(2) No. 4 ISSN: 0009-3068 > > > > LENGTH: 1564 words > > > > The idea of alien intelligences calmly watching our every move > > anddiscussing > > > > the right time to take the Earth from us is the stuff of books, > > movies and nightmares. But how would you feel if you knew thatevery > > time you sat in the dentist's chair your dentist was fighting a > > losing battle with exactly such afoe? > > > > One of the most startling discoveries to come out of the > > burgeoning world of microbiology in the past two decades is the > fact > > that bacteria can communicate. > > > > In fact, not just communicate but converse on alevel where they can > > induce each other to switch on dormant genes that then have the > > capacity to do you harm. > > > > Dental plaque, it turns out, is the least of our worries. The > > superbug MRSA is part of the same phenomenon, called 'quorum > sensing'. > > > > Quorum sensing is the ability of bacteria to communicate and > > coordinate behaviour using signalling molecules called > autoinducers. > > Autoinducers are continuously produced by bacteria but when their > > concentration reaches a certain threshold--that is to say, when the > > bacteria producing it have a quorum--they switch on transcription > > genes withinthe bacteria's DNA telling it to do two things: to > > produce more autoinducer and, crucially, to change behaviour. > > > > It is the behaviour change that does the damage. Most bacteria > > spend their lives as free-swimming, planktonic organisms but when > > mandated to do so by the autoinducer will switch to a sessile > > lifestyle, dropping out of the swimming phase and anchoring to the > > nearest solid surface, be it a tooth, contact lens or the newly- > > minted plastic ball-joint of a hip replacement. There they form > > > > biofilms--bacterial mats that reduce the effectiveness of > antibiotics > > and where the local concentration of autoinducer goes through the > > roof. Once a biofilm is established it is very difficult to get rid > > of--witness the ubiquity of dental plaque and the dogged resistance > > of MRSA to treatment. > > > > Dietrich Mack at the University of Swansea and his group have > > beenactive in discovering just how quorum sensing works. In > > Staphylococcus aureus and S. epidermidis--the microbes responsible > > for both MRSA and implantation rejects--they have identified at > least > > two major gene expression pathways responsible for initiating > biofilm > > formation, one based on a polysaccharide and the other on a > peptide. > > But as Mack acknowledges, 'Our research shows that the expression > of > > these pathways is not straightforward. In certain cases where > > weinhibit a gene responsible involved in quorum sensing it can > > actually increase the amount of biofilm formed'. > > > > Quorum sensing, however, does more than merely initiate biofilm > > formation. It is a potent weapon of war between bacteria. For > > example, the four most common strains of S. aureus, including MRSA, > > use four slightly different autoinducers to initiate biofilm > > formation, all of which also aggressively inhibit the receptor > sites > > of the other strains. > > > > The strain that reaches its critical quorum level first not only > gets > > to put down its biofilm inducing roots first, it also gets to > silence > > its competitors, preventing them from building up more of theirown > > autoinducer. > > > > Production of orthopaedic implants--from artificial hips to hip > > and knee joints--is an expanding industry worth $2.5bn in 2005 in > > Europe, according to Frost & Sullivan. Eighty per cent of hospital- > > acquired infections are associated with implants or other 'in- > > dwelling' medical devices, while 60% of hospital infections > generally > > involve biofilms. Since MRSA and other biofilm-infections are > > frequently fatal, there are compelling financial and ethical > reasons > > to find ways of preventing biofilm formation. > > > > Just how biofilms heighten resistance to antibiotics is not > > straightforward. > > > > It may be simply because the ability of antibiotics to penetrate > the > > biofilm to the bacterial cells themselves is impaired, or it may be > > that the life-style change from planktonic to sessile changes the > > metabolic state of the bacterial cell and therefore its resistance > to > > antibiotics. A more extreme suggestion is that the bacteria are > > fundamentally altered in some way so that they behave more like a > > multicellular tissue than a loose agglomeration of co-operating > single > > > > cells. > > > > For years, the approach to tackle biofilms has been incorporate > > antimicrobial agents in biomaterials that are to be used within the > > body, but the problem is the incredible ability of bacteria to > > develop antibiotic resistance. Because of their short generation > time > > and their uncomplicated genomes, the fact is that bacteria can > mutate > > and develop resistance faster than we can develop drugs to combat > > them. Simply killing bacteria in situ can lead to dead microbial > cells > > > > and associated detritus fouling the surfaces of crucial implants. > > Defeating biomaterial biofilm formation requires a different > > approach, one that does not result in the death of the bacterium > but > > rather in the neutralisation of its malevolence. > > > > There are several possibilities: coating the biomaterial with > > substances that prevent bioadhesion, developing responsive surfaces > > that react to bacterial invasion, controlling the orientation of > > surface-tethered adhesion molecules, or interfering with receptor- > > ligand specific adhesion. But as Llinos and Geoff s > of > > the AO Foundation in Davos, Switzerland, point out: 'no surface > > modification or coating fully prevents bacterial adhesion'. > > This leaves perhaps the most exciting possibility of all: > > disabling their quorum sensing mechanisms so that the bacteria > cannot > > form biofilms in the first place. > > > > Several signal molecule families involved in quorum sensing have > > been identified in Gram-negative bacteria--those with two sets of > > cellmembranes--like Pseudomonas aeruginosa, but the most > intensively > > studied is the N-acylhomoserine lactone (AHL) family. AHLs contain > a > > homoserine lactone ring attached via an amide bond to an acyl side > > chaincontaining anything from four to 14 carbon atoms. > > > > Once the AHL reaches a critical threshold, concentration members > > of the LuxR and LuxN family of transcriptional activator genes are > > switched on, forming proteins that start binding the bacteria to > the > > substrate, thereby beginning biofilm formation. Variations in the > > chain length and oxidation at the 3-position provide different Gram- > > negative bacteria with species-specific languages with which they > can > > communicate with their own kind. > > > > Yet, since 75 Gram-negative bacterial species are known to use > > AHL, and only 25 AHL varieties have been found, it must also be the > > casethat some of these species share a common tongue and can > > therefore talk across species boundaries. > > > > Since biofilms usually consist of a multitude of different bacteria > > species--which have different niches and therefore do not compete > > with each other--this implies that different bacteria co- operate in > > biofilm formation. > > > > It is a frightening thought. > > > > There is some good news, however. Some natural molecules have > > beenfound to interfere with AHL-mediated quorum sensing and the > most > > important of these are halogenated furanones produced by the large > > marine alga Delisea pulchra. > > > > Halogenated furanones are structurally similar to AHLs and > interfere > > with the ability of AHLs to bond to biomaterial surfaces. An > analogy > > would be the way that carbon monoxide interferes with oxygen's > > ability to bond with haemoglobin > > y occupying the haemoglobin's receptor sites first. > > > > The Australian firm Biosignal is leading the way in the > > application of antibiofilm agents to contact lenses. Biosignal's > > compounds are based on the naturally occurring furanones from > Delisea > > pulchra. As the trend toward long-wearing disposable contact lenses > > gathers momentum it is increasingly important to make sure that the > > lenses do not grow a biofilm and cause eye infection. An initial > > human safety trial of their furanone-based coating was completed > last > > year and the results look positive. 'The potential market is > > enormous', says Oredsson, Biosignal's ceo, 'somewhere > between > > $5bn and $6bn per year. We plan to levy a small but meaningful > > royalty on the use of Biosignal's proprietary technology--we aim > for > > around 5%.' > > > > Gram-positive bacteria like S. aureus and Staphylococcus > > epidermidis--the major cause of implant biofilm infections--use > > peptides rather than AHLs as signal molecules. In S. epidermidis a > > single peptide, once it has reached its critical level, activates > an > > accessory gene regulator (agr) operon that results in the synthesis > > of PolysaccharideIntercellular Adhesin (PIA), a molecular glue that > > starts the process of biofilm formation. > > > > An inhibiting peptide, appropriately known as RIP, can inhibit > > biofilm formation in both S. epidermidis and S. aureus and is under > > investigation as a potential treatment for Staphylococcus- induced > > infections. > > > > As yet, however, there is no magic bullet for preventing Gram- > > positive, quorum sensing-induced, biofilm formation, and scaling up > > thesetechniques to clinical level offers substantial technical > > challenges. When asked exactly how inhibition of quorum sensing can > > be used to stop MRSA biofilm formation, > > > > Dietrich Mack responded: 'That is a verygood question. I would like > > to know the answer to that too.' > > > > But there is everything left to play for. Oredsson acknowledges > > that contact lenses are just the tip of the iceberg, and that the > > impetus behind quorum sensing remains a cure for serious bacterial > > infections, including those caused y MRSA. > > > > Corfield is a science writer based in Oxfordshire > > > > LOAD-DATE: March 27, 2007 > > > > McGiffert > > > > Campaign Manager > > > > www.StopHospitalInfections.org > > > > 512-477-4431 ext 115 > > > > 512-477-8934 fax > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2007 Report Share Posted March 30, 2007 They seem more stable on Lariam, btwn 150 000 and 200 000, many of my other symptoms especially heart ones subside on Lariam, but sometimes make a come back in the last 2 days of the week (I take Lariam once a week) as if I needed topping off. I am quite sure that's the reason why I can't go off it. My ID doc gets terrified at the very thought of me taking Lariam so, although I did take it once every 5 days for a while, I have now pulled back to once a week. Nelly [infections] Re: Low Platelets DO your platelets rebound while on Lariam?Are they above or below 150? (Range on a standard USA test is about 200 to 400)Barb> > Chemistry and Industry> > > > February 26, 2007> > > > Killer dialogue: when bacteria are told to do so they form biofilms > > on solid surfaces which reduce the effectiveness of antibiotics. > > Corfield looks at ways of inhibiting these instructions;> > > > Bacteria> > > > BYLINE: Corfield, > > > > SECTION: Pg. 24(2) No. 4 ISSN: 0009-3068> > > > LENGTH: 1564 words> > > > The idea of alien intelligences calmly watching our every move > > anddiscussing> > > > the right time to take the Earth from us is the stuff of books, > > movies and nightmares. But how would you feel if you knew thatevery > > time you sat in the dentist's chair your dentist was fighting a > > losing battle with exactly such afoe?> > > > One of the most startling discoveries to come out of the > > burgeoning world of microbiology in the past two decades is the > fact > > that bacteria can communicate.> > > > In fact, not just communicate but converse on alevel where they can > > induce each other to switch on dormant genes that then have the > > capacity to do you harm.> > > > Dental plaque, it turns out, is the least of our worries. The > > superbug MRSA is part of the same phenomenon, called 'quorum > sensing'.> > > > Quorum sensing is the ability of bacteria to communicate and > > coordinate behaviour using signalling molecules called > autoinducers. > > Autoinducers are continuously produced by bacteria but when their > > concentration reaches a certain threshold--that is to say, when the > > bacteria producing it have a quorum--they switch on transcription > > genes withinthe bacteria's DNA telling it to do two things: to > > produce more autoinducer and, crucially, to change behaviour.> > > > It is the behaviour change that does the damage. Most bacteria > > spend their lives as free-swimming, planktonic organisms but when > > mandated to do so by the autoinducer will switch to a sessile > > lifestyle, dropping out of the swimming phase and anchoring to the > > nearest solid surface, be it a tooth, contact lens or the newly-> > minted plastic ball-joint of a hip replacement. There they form> > > > biofilms--bacterial mats that reduce the effectiveness of > antibiotics > > and where the local concentration of autoinducer goes through the > > roof. Once a biofilm is established it is very difficult to get rid > > of--witness the ubiquity of dental plaque and the dogged resistance > > of MRSA to treatment.> > > > Dietrich Mack at the University of Swansea and his group have > > beenactive in discovering just how quorum sensing works. In > > Staphylococcus aureus and S. epidermidis--the microbes responsible > > for both MRSA and implantation rejects--they have identified at > least > > two major gene expression pathways responsible for initiating > biofilm > > formation, one based on a polysaccharide and the other on a > peptide. > > But as Mack acknowledges, 'Our research shows that the expression > of > > these pathways is not straightforward. In certain cases where > > weinhibit a gene responsible involved in quorum sensing it can > > actually increase the amount of biofilm formed'.> > > > Quorum sensing, however, does more than merely initiate biofilm > > formation. It is a potent weapon of war between bacteria. For > > example, the four most common strains of S. aureus, including MRSA, > > use four slightly different autoinducers to initiate biofilm > > formation, all of which also aggressively inhibit the receptor > sites > > of the other strains. > > > > The strain that reaches its critical quorum level first not only > gets > > to put down its biofilm inducing roots first, it also gets to > silence > > its competitors, preventing them from building up more of theirown > > autoinducer.> > > > Production of orthopaedic implants--from artificial hips to hip > > and knee joints--is an expanding industry worth $2.5bn in 2005 in > > Europe, according to Frost & Sullivan. Eighty per cent of hospital-> > acquired infections are associated with implants or other 'in-> > dwelling' medical devices, while 60% of hospital infections > generally > > involve biofilms. Since MRSA and other biofilm-infections are > > frequently fatal, there are compelling financial and ethical > reasons > > to find ways of preventing biofilm formation.> > > > Just how biofilms heighten resistance to antibiotics is not > > straightforward.> > > > It may be simply because the ability of antibiotics to penetrate > the > > biofilm to the bacterial cells themselves is impaired, or it may be > > that the life-style change from planktonic to sessile changes the > > metabolic state of the bacterial cell and therefore its resistance > to > > antibiotics. A more extreme suggestion is that the bacteria are > > fundamentally altered in some way so that they behave more like a > > multicellular tissue than a loose agglomeration of co-operating > single> > > > cells.> > > > For years, the approach to tackle biofilms has been incorporate > > antimicrobial agents in biomaterials that are to be used within the > > body, but the problem is the incredible ability of bacteria to > > develop antibiotic resistance. Because of their short generation > time > > and their uncomplicated genomes, the fact is that bacteria can > mutate > > and develop resistance faster than we can develop drugs to combat > > them. Simply killing bacteria in situ can lead to dead microbial > cells> > > > and associated detritus fouling the surfaces of crucial implants. > > Defeating biomaterial biofilm formation requires a different > > approach, one that does not result in the death of the bacterium > but > > rather in the neutralisation of its malevolence.> > > > There are several possibilities: coating the biomaterial with > > substances that prevent bioadhesion, developing responsive surfaces > > that react to bacterial invasion, controlling the orientation of > > surface-tethered adhesion molecules, or interfering with receptor-> > ligand specific adhesion. But as Llinos and Geoff s > of > > the AO Foundation in Davos, Switzerland, point out: 'no surface > > modification or coating fully prevents bacterial adhesion'.> > This leaves perhaps the most exciting possibility of all: > > disabling their quorum sensing mechanisms so that the bacteria > cannot > > form biofilms in the first place.> > > > Several signal molecule families involved in quorum sensing have > > been identified in Gram-negative bacteria--those with two sets of > > cellmembranes--like Pseudomonas aeruginosa, but the most > intensively > > studied is the N-acylhomoserine lactone (AHL) family. AHLs contain > a > > homoserine lactone ring attached via an amide bond to an acyl side > > chaincontaining anything from four to 14 carbon atoms. > > > > Once the AHL reaches a critical threshold, concentration members > > of the LuxR and LuxN family of transcriptional activator genes are > > switched on, forming proteins that start binding the bacteria to > the > > substrate, thereby beginning biofilm formation. Variations in the > > chain length and oxidation at the 3-position provide different Gram-> > negative bacteria with species-specific languages with which they > can > > communicate with their own kind.> > > > Yet, since 75 Gram-negative bacterial species are known to use > > AHL, and only 25 AHL varieties have been found, it must also be the > > casethat some of these species share a common tongue and can > > therefore talk across species boundaries.> > > > Since biofilms usually consist of a multitude of different bacteria> > species--which have different niches and therefore do not compete > > with each other--this implies that different bacteria co-operate in > > biofilm formation. > > > > It is a frightening thought.> > > > There is some good news, however. Some natural molecules have > > beenfound to interfere with AHL-mediated quorum sensing and the > most > > important of these are halogenated furanones produced by the large > > marine alga Delisea pulchra.> > > > Halogenated furanones are structurally similar to AHLs and > interfere > > with the ability of AHLs to bond to biomaterial surfaces. An > analogy > > would be the way that carbon monoxide interferes with oxygen's > > ability to bond with haemoglobin> > y occupying the haemoglobin's receptor sites first.> > > > The Australian firm Biosignal is leading the way in the > > application of antibiofilm agents to contact lenses. Biosignal's > > compounds are based on the naturally occurring furanones from > Delisea > > pulchra. As the trend toward long-wearing disposable contact lenses > > gathers momentum it is increasingly important to make sure that the > > lenses do not grow a biofilm and cause eye infection. An initial > > human safety trial of their furanone-based coating was completed > last > > year and the results look positive. 'The potential market is > > enormous', says Oredsson, Biosignal's ceo, 'somewhere > between > > $5bn and $6bn per year. We plan to levy a small but meaningful > > royalty on the use of Biosignal's proprietary technology--we aim > for > > around 5%.'> > > > Gram-positive bacteria like S. aureus and Staphylococcus > > epidermidis--the major cause of implant biofilm infections--use > > peptides rather than AHLs as signal molecules. In S. epidermidis a > > single peptide, once it has reached its critical level, activates > an > > accessory gene regulator (agr) operon that results in the synthesis > > of PolysaccharideIntercellular Adhesin (PIA), a molecular glue that > > starts the process of biofilm formation.> > > > An inhibiting peptide, appropriately known as RIP, can inhibit > > biofilm formation in both S. epidermidis and S. aureus and is under > > investigation as a potential treatment for Staphylococcus-induced > > infections.> > > > As yet, however, there is no magic bullet for preventing Gram-> > positive, quorum sensing-induced, biofilm formation, and scaling up > > thesetechniques to clinical level offers substantial technical > > challenges. When asked exactly how inhibition of quorum sensing can > > be used to stop MRSA biofilm formation,> > > > Dietrich Mack responded: 'That is a verygood question. I would like > > to know the answer to that too.'> > > > But there is everything left to play for. Oredsson acknowledges > > that contact lenses are just the tip of the iceberg, and that the > > impetus behind quorum sensing remains a cure for serious bacterial > > infections, including those caused y MRSA.> > > > Corfield is a science writer based in Oxfordshire> > > > LOAD-DATE: March 27, 2007> > > > McGiffert> > > > Campaign Manager> > > > www.StopHospitalInfections.org> > > > 512-477-4431 ext 115> > > > 512-477-8934 fax> >> > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2007 Report Share Posted October 7, 2007 Dear , The following report appears to relate to your circumstance. It appears evident that cytoxan and Fludarabine in combination is very active against b-cell malignancies but also carries this risk ... or at least a notable association .... with low platelets. Please keep us updated. All the best, ~ Karl Brief Communication Fludarabine Combination Regimen Severely Affected Peripheral Blood Stem Cell Mobilization e Laszloa, Piero Galienib, Donatella Raspadoric, Tozzic, Francesco Lauriac, Giovanni ellia aDepartment of Hematoncology, European Institute of Oncology, Milan; bDepartment of Hematology, San Benedetto del Tronto Hospital, San Benedetto del Tronto, cDepartment of Hematology, University of Siena, Siena, Italy Address of Corresponding Author Acta Haematologica 2004;111:228-229 (DOI: 10.1159/000077572) -------------------------------------------------------------------------------- Abstract Sorry, there is no abstract. Read the first few lines of the text instead! Fludarabine-containing regimens have been reported to be effective in the treatment of B cell chronic lymphocytic leukemia (B-CLL) and low-grade non-Hodgkin's lymphomas (LG-NHL) [1, 2] either as first-line treatment or as salvage therapy. However, some reports focused their attention on the possibility that fludarabine may affect peripheral blood stem cell (PBSC) yields in B-CLL and other disorders [3-5]. ** Very recently, Tournilhac et al. [6] reported their experience in 38 patients affected by B-CLL and treated with **combined oral fludarabine and cyclophosphamide ** as a first-line treatment: the first mobilization was unsuccessful in 32 patients and was associated with a low platelet count prior to mobilization. We have previously reported a similar observation pointing to a possible correlation between fludarabine-based chemotherapy regimens employed before mobilization and the inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL [4]. We further evaluated PBSC collection from 13 consecutive patients, 5 with acute myeloid leukemia (AML) and 8 with LG-NHL, who received a fludarabine-based chemotherapy regimen before PBSC mobilization (table 1). For each collection we evaluated CD34+ × 106/kg cells, CFU-GM × 104/kg and CD34+/CD33- × 106/kg to distinguish early stem and multipotent progenitor cells. Among the 5 AML patients, 2 had an unsuccessful mobilization, while in the other 3 patients 3.2 CD34+ × 106/kg could be harvested. Copyright © 2004 S. Karger AG, Basel Low Platelets This question is for anyone who has an opinion/suggestion. I completed six rounds of FCR3 in April of 2005 and they gave me a Complete Remission dx. At the time my platelets were at 98. In May '05 they were at 130, by August '05 back down to 110. Then in December '05 at 102. In June 2007 at 87. All my other CBC numbers are in the normal range. When I asked my oncologists about the results they said that everything was OK and my platelets would eventually come back up. On Thursday (October 4th) I went to my family care doctor because of a chest cold, he prescribed an antibiotic for the cold, and drew blood to check my white counts. All of the CBC numbers were in the normal range except for my platelets which were at 5! He thought it a incorrect reading, took another sample and it came back today as 6! I'm on my way to the ER for a transfusion. On Monday I have an appointment with my oncologist to sort out the problem. Thanks for your help Tipton age 63, dx 2001, FCR3 4-05, Complete Remission --------------------------------- Check out the hottest 2008 models today at Autos. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2008 Report Share Posted September 24, 2008 When I was at a conference, Dr. Shaw looked at my labs and my son's Platelets were also low. He told me that it was a yeast overgrowth problem. I think arabinose?  Evidently they put off byproducts that destroy the platelets. Get rid of the yeast problem and the platelets go back to normal. Hope that helps. Kelley From: jeksmom062405 <tarakeelean@...> Subject: [ ] Low Platelets Date: Wednesday, September 24, 2008, 8:10 AM Hi Everyone, We had some blood tests done on my son, and I just heard back from the doctor. Apparently his platelets are low, 80, in a range of 202-403, I believe. The doctor emailed me that they are concerned about his low platelets, and would like to talk at 12:30pm today. They have also told me to stop the fish oil. Now I am beside myself. We checked the blood work that was done in January, and his platelets were normal. Any thoughts, feedback, or guidance would be extremely helpful. Thanks, Tara Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2008 Report Share Posted September 24, 2008 I don't know, but I can only imagine how concerning this must be. Please keep us posted after your 12:30 discussion. cyber hugs, Darlene > > Hi Everyone, > > We had some blood tests done on my son, and I just heard back from the > doctor. Apparently his platelets are low, 80, in a range of 202- 403, > I believe. The doctor emailed me that they are concerned about his > low platelets, and would like to talk at 12:30pm today. They have > also told me to stop the fish oil. > > Now I am beside myself. We checked the blood work that was done in > January, and his platelets were normal. > > Any thoughts, feedback, or guidance would be extremely helpful. > > Thanks, > Tara > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2009 Report Share Posted June 13, 2009 Hi Roni and anyone else, I know this is an old post, but I am on the third month of a candida cleanse and have been feeling run down, flu-like, heart palpitations, fatigue - I had my blood tested and I have low hematocriton and platelets. Did you find out if this may be a system of the detox? Thanks, > > Just want to know if anyone out there has had a low platelet count? > I just got my blood work from my doctor. Could this be related to > candida? > > Thanks! > Roni > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2009 Report Share Posted June 13, 2009 , some " candida cleanses " disallow the wrong foods, and simultaneously allow several high-carbohydrate foods that WILL impair your progress (white rice, whole and exotic grains etc). Detox or die-off " symptoms " should be pretty well handled by increasing phase II liver detox ability, which uses glutathione that is increased by cold-extracted whey and selenium, an approach used by our group but not many others. The approach is proven by ample research and practice, while reducing Phase II detox ability is not. To reduce candida you'd need to control bowel ecology, pathogens that caused the candida flourish in the first place, by using prebiotic inulin and maybe high-dose probiotics. Unfortunately, despite a large and growing body of evidence, the concept is relatively unknown or worse, viewed with suspicion even by quasi-authoritative individuals like the one who writes for HealingCrow.com, a site that is especially mired by an old lady's 50-year-old prejudice. See it for what it is Does a " candida cleanse " really exist at all? We in the candidaisis group fix digestive issues primarily with nutrition and diet and the ability to detox better, not by " cleansing " as such. This particular group doesn't use the phrase " candida cleanse " that often; perhaps your routine and terminology came from somewhere else? If so, ask them for another bright idea and then go ahead and apply what you've learned here. We often supplement with vitamin B complex; you can use extra b-12 methylcobalamin sublingual. Also, more alkalinity, more oxygen or ozone therapy bring up tissue oxygen and energy. So should the whey and selenium. No, I don't think it's linked as much to detoxing as to general acidity and nutrition, and NOT detoxing. Duncan Crow ( a wholistic consultant in Canada) http://tinyurl.com/duncancrow > > Hi Roni and anyone else, > > I know this is an old post, but I am on the third month of a candida cleanse and have been feeling run down, flu-like, heart palpitations, fatigue - I had my blood tested and I have low hematocriton and platelets. Did you find out if this may be a system of the detox? > Thanks, > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2009 Report Share Posted June 13, 2009 Duncan, Is this a group you created? Because you are everywhere here. My diet and lifestyle is as clean and holistic as it gets and has been now for years. Not quite sure what you meant by all what you wrote below. I am on a great probiotic (and I know you recommend whey but I do not eat dairy) and an FOS - (inulin is too much sugar for me.) I have muscled tested this, dowsed it, tried it, spoke with an medical intuitive and not every diet of for every person. What you recommend does not work for me - we spoke several years back and you even said wine was ok. It is NOT ok for me personally as it totally exacerbates candida. The reason why I ask if this is your group under your philosophy, I do want to find a group that is open to many protocols, not just one. Please let me know if this group is restricted to just your philosophy. Thanks, > > > > Hi Roni and anyone else, > > > > I know this is an old post, but I am on the third month of a candida cleanse and have been feeling run down, flu-like, heart palpitations, fatigue - I had my blood tested and I have low hematocriton and platelets. Did you find out if this may be a system of the detox? > > Thanks, > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 31, 2010 Report Share Posted January 31, 2010 Hi Hi I have had low platelet and Hgb for a long time, best you ask Zavie or Lottie about my low platelet, but not to worry SkipD dx'ed 32++ year now  ________________________________ From: Sharon <taylorsharon1214@...> Sent: Sat, January 30, 2010 6:34:43 PM Subject: [ ] low platelets hi this is the first time i have posted on this site, i have had cml for just one year. iwas dx in early chronic stage i was on 400mg gleevec for 5 months until my platelets started to fall my pcr test wasnt two good i was only having a slow responce i changed to tasigna in oct started out good then after 6 weeks my platelets were down again i was taken off meds for 3 weeks platelets recoverd and was at 102 started back on tasigna at a lower dose of 400mg once a day 4 weeks in and my platelets are 59... i feel realy well on tasigna but im feeling very disheartend and upset about my platelets, has anyone else had this prob ? sharon,x, __________________________________________________________________ Canada Toolbar: Search from anywhere on the web, and bookmark your favourite sites. Download it now http://ca.toolbar.. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 31, 2010 Report Share Posted January 31, 2010 Sharon, It was normal in Gleevec trials for people to have low platelets. At MDA as long as the platelets were above 50,000, they were not concerned. If they dropped below that, the medicine would be stopped until they came up to that point and they started again. Other CMLer's that I know had platelet counts below that and continued the Gleevec. I have been on Gleevec since Dec. 1998 and my platelets are always low, usually 70,000-80,000. I just live with it. I think it's a part of the leukemia treatment. When I asked the research nurse about it at MDA she told me that they've dealt with people with platelet counts of 2,000!....that I needn't be concerned. Hope this helps! Gay Bratton On Jan 31, 2010, at 2:58 PM, Skip Duffie wrote: > Hi > > Hi > I have had low platelet and Hgb for a long time, best you ask Zavie > or Lottie about my low platelet, but not to worry > SkipD > dx'ed 32++ year now > > > ________________________________ > > From: Sharon <taylorsharon1214@...> > > Sent: Sat, January 30, 2010 6:34:43 PM > Subject: [ ] low platelets > > hi this is the first time i have posted on this site, i have had cml > for just one year. iwas dx in early chronic stage i was on 400mg > gleevec for 5 months until my platelets started to fall my pcr test > wasnt two good i was only having a slow responce i changed to > tasigna in oct started out good then after 6 weeks my platelets were > down again i was taken off meds for 3 weeks platelets recoverd and > was at 102 started back on tasigna at a lower dose of 400mg once a > day 4 weeks in and my platelets are 59... i feel realy well on > tasigna but im feeling very disheartend and upset about my > platelets, has anyone else had this prob ? sharon,x, > > __________________________________________________________ > Canada Toolbar: Search from anywhere on the web, and bookmark > your favourite sites. Download it now > http://ca.toolbar.. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 1, 2010 Report Share Posted February 1, 2010 thank you to all that replied to my post it makes me feel soooo much better to be able to talk with people who understand.. ill sleep better tonight thank you all lv sharon.x. Quote Link to comment Share on other sites More sharing options...
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