Re: Help with details of PCR report

[Guest guest]

Hi Barbara,

I would highly suggest that you see a specialist and get back on some type of

treatment. If you wait until your white count goes up before acting, you will

have relapsed significantly. The PCR will rise long before your white count

will which is why we're all monitored with PCR's now and not just CBC's.

The longer you stay off treatment, the higher your chance of developing a

mutation as the CML cells divide. You really want to stop the CML cells from

multiplying and the sooner the better.

You have several drug options to try which will hopefully give you good results

without serious side effects It may be trial and error to find which drug is

best for you but you really shouldn't wait.

Tracey

>

> I was diagnosed July 06 - May/07 was my first PCR from this lab. Could anyone

help me understand what the different columns represent?  I have been off

Gleevec since middle of Sept (for medical reasons and bad side effects) and all

of my office labs have continue to show WBC in normal range.  The day they took

blood for the PCR, my WBC was still in the normal range, do the results below

alert me that my WBC will soon be increasing and I need to look at going back on

some meds?  I don't see my doctor again until March and want to start

researching the choices which may include going to one of the CML specialist.  I

guess we will have to look at the next generation as Gleevec side effects and

toxicity level in my system was just too much to tolerate anymore. 

> Thanks for any explanation.

>  

> Date            Major e1312   Major e14a2    Major Combined       Minor e1a2

>  

> 12/3/09            .002%       not detected      

 .002%                         not detected

>  

> 8/19/09             ND             ND                 

ND                              ND

> 1/14/09                                           DITTO FOR ALL COLUMNS ACROSS

> 6/11/08                                           DITTO FOR ALL COLUMNS ACROSS

>  

> 5/15/07             .006%         ND                  

..006                           ND

>  

> Barbara Hundley

> Fayetteville, GA

>

>

>

>

>

>

[Guest guest]

's advice is excellent. You do not want to develop a mutation. The disease

could be much more difficult to treat. If you had problems handling gleevec my

experience has been that sprycel is much more effective and the side effects

have been nearly negligible.

Sent from my iPhone

On Dec 10, 2009, at 5:38 PM, " traceyincanada " <traceyincanada@...> wrote:

Hi Barbara,

I would highly suggest that you see a specialist and get back on some type of

treatment. If you wait until your white count goes up before acting, you will

have relapsed significantly. The PCR will rise long before your white count will

which is why we're all monitored with PCR's now and not just CBC's.

The longer you stay off treatment, the higher your chance of developing a

mutation as the CML cells divide. You really want to stop the CML cells from

multiplying and the sooner the better.

You have several drug options to try which will hopefully give you good results

without serious side effects It may be trial and error to find which drug is

best for you but you really shouldn't wait.

Tracey

>

> I was diagnosed July 06 - May/07 was my first PCR from this lab. Could anyone

help me understand what the different columns represent? I have been off

Gleevec since middle of Sept (for medical reasons and bad side effects) and all

of my office labs have continue to show WBC in normal range. The day they took

blood for the PCR, my WBC was still in the normal range, do the results below

alert me that my WBC will soon be increasing and I need to look at going back on

some meds? I don't see my doctor again until March and want to start

researching the choices which may include going to one of the CML specialist. I

guess we will have to look at the next generation as Gleevec side effects and

toxicity level in my system was just too much to tolerate anymore.

> Thanks for any explanation.

>

> Date Major e1312 Major e14a2 Major Combined Minor e1a2

>

> 12/3/09 .002% not detected .002%

not detected

>

> 8/19/09 ND ND ND

ND

> 1/14/09 DITTO FOR ALL COLUMNS ACROSS

> 6/11/08 DITTO FOR ALL COLUMNS ACROSS

>

> 5/15/07 .006% ND .006

ND

>

> Barbara Hundley

> Fayetteville, GA

>

>

>

>

>

>

[Guest guest]

Barbara,

I agree that you need the advice of a specialist, I do hope you are already

with a good cml oncologist! I don't think it's time to panic. I would press

to see you doctor before March 2010, however. I had a recent similar round

of positive PCR after years of negative. My ONC ran three consecutive PCR

tests, one month apart, and the numbers kept growing. She increased my

Gleevec from 400mg daily to 800. In less than three weeks my PCR was again

undetectable and remains so.

Keep the faith. remain positive and keep after your doctor. If you need a

different medication just be thankful there are new ones now.

Troxel

On Thu, Dec 10, 2009 at 1:45 PM, Barbara Hundley <barbdig@...> wrote:

>

>

> I was diagnosed July 06 - May/07 was my first PCR from this lab. Could

> anyone help me understand what the different columns represent? I have been

> off Gleevec since middle of Sept (for medical reasons and bad side effects)

> and all of my office labs have continue to show WBC in normal range. The

> day they took blood for the PCR, my WBC was still in the normal range, do

> the results below alert me that my WBC will soon be increasing and I need to

> look at going back on some meds? I don't see my doctor again until March

> and want to start researching the choices which may include going to one of

> the CML specialist. I guess we will have to look at the next generation as

> Gleevec side effects and toxicity level in my system was just too much to

> tolerate anymore.

> Thanks for any explanation.

>

> Date Major e1312 Major e14a2 Major Combined Minor

> e1a2

>

> 12/3/09 .002% not detected

> .002% not detected

>

> 8/19/09 ND ND

> ND ND

> 1/14/09 DITTO FOR ALL COLUMNS

> ACROSS

> 6/11/08 DITTO FOR ALL COLUMNS

> ACROSS

>

> 5/15/07 .006% ND

> .006 ND

>

> Barbara Hundley

> Fayetteville, GA

>

>

[Guest guest]

So what did you stay on. You do know of citric fruit brakes Gleevec down,which

would help  give you a poor pcR reading. 600 Gleevec 3 years dx 12/23/04

> 

>