Brca1

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I know some of you have been tested and have the BraCa gene and may know someone

who does have it. I thought you might be interested in this article.

Computer Modeling Defines Effects of Prophylactic Strategies for BRCA1/2

Mutation rs

" Researchers from Stanford University have used computer modeling to define the

benefits of different prophylactic strategies to reduce the risk of dying of

breast cancer among individuals with a BRCA1/2 mutation. The details of this

study appeared in the January 20, 2010 issue of the Journal of Clinical

Oncology. Inherited mutations in two genes—BRCA1 and BRCA2—have been found to

greatly increase the lifetime risk of developing breast and ovarian cancer.

Mutations in these genes can be passed down through either the mother’s or the

father’s side of the family. Women with a BRCA1 mutation have a 47-66% lifetime

risk of developing breast cancer, and women with a BRCA2 mutation have a 40-57%

lifetime risk of developing the disease. These statistics are compared with a

13% lifetime risk of breast cancer in the general population. Early onset

screening with mammography and magnetic resonance imaging (MRI), prophylactic

oophorectomy, and mastectomy are three strategies that are used to reduce the

risk of dying of breast cancer in BRCA1/2 mutation carriers, but little is known

about the absolute benefit of each these approaches. " You may view the entire

article at the website listed below:

http://www.caring4cancer.com/go/cancer/news?NewsItemId=44518

FYI,

Lottie Duthu