Re: Sprycel Dose Question--Matt again

[Guest guest]

Hi again, Matt,

I forgot to mention that the reason for taking all the Sprycel in one dose is

that there are fewer side effects that way. Dividing the dose has a history of

producing more side effects.

Also, I have been PCRU since my first quarterly check-up after beginning

So\prycel in 2004.

[ ] Sprycel Dose Question

On my vist to my oncologist at Moffitt CC last week,

my doctor wanted to increase my daily dosage of

Sprycel from 70 mg to 100 mg per day. While I

unsuccessfully lobbied to be kept at the lower dose

he stated that he wanted me to be kept at a theraputic

dose.

I should point that on my last two PCR test, I had a two

log increase, but that was while I was on Tasigna and

on Sprycel at 50 mg. I have not been tested yet on

Sprycel at 70 mg, which was the basis for my argument.

However, he was disappointed that we went from PCRU

to two successive PCRs showing increases. However, I

had to take a break on Tasigna as my blood pressure was

hitting 160/120 and I knew it was the medication, which

he disputed as I had gained a lot of weight on Gleevec.

Once I got on Sprycel, my BP rocked down as I had

projected to 126/76 which is more normal for me.

So this long story, to get my question out is this: If you

are on or have been on Sprycel, what was your normal

dosage? Was it 100 mg or are there people that are or

were on lower doses?

Matt

Florida