Re: Anyone taking Tasigna may be interested in this

[Guest guest]

> In other words, the reduced dose of nilotinib that you have been on, 600 mg

per day (due to the side effects that you experienced in the beginning of

therapy) should be as effective as the currently FDA approved dose of 800mg/day.

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Hi Sharon,

It is really no surprise that Tasigna is more effective than Gleevec. But the

really good news is that the lower dose is just as effective, esp. for many

people who are having to pay quite a bit for their drug, like a % or with

Medicare Part D.

It is really the same with Sprycel, where they thought the dose would be 140mg

and that has more side effects and 100mg is just as effective.

When I asked Dr. Druker if he thought Tasigna or Sprycel was a more effective

drug, he said he considered them to be about the same. When they talk about them

in the lab, they will say something like Tasigna is 30x more potent than

Gleevec.....and Sprycel is 300x more potent than Gleevec. But he said in the

human body they are about equal because the dose of Tasigna that you take is

much larger than the dose of Sprycel (600-800mg vs 100mg or less) and that the

half life of the drugs is different.....and that when you do the complicated

math working in all these variables, the drugs are probably comparable. Of

course for any one individual, one drug can be more effective than the other.

Thanks for sharing this information.

C.