Re: Fluid around the eyes.

[Guest guest]

Hi Jamy,

Puffy eyes are a side effect of Gleevec. What we don't know here are the

side effects of Veenat. Veenat is a Generic Gleevec and it could be slightly

different than Gleevec. Pale skin is also a side effect of Gleevec.

The standard dose of Gleevec is 400 mg. Is there a reason that he is on 300

mg?

Ask his doctor if he access to some of the other CML drugs like Sprycel or

Tasigna. They work well for CML and may not have the same side effects as

Veenat.

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

Jamshid

Sent: April 24, 2010 10:10 AM

Subject: [ ] Fluid around the eyes.

Dear friends,

my father diagonalized CML and under Veenat(Gleevec) 300mg for the past 6

months. His blood counts looks normal after taking the drug. Now the main

issue is (besides pale skin) swelling around the eyes due to fluid and its

quite disturbance since eyes shrinks. But Doctor says its due to the side

effects of Gleevec and some time prescribed one Tablet but not cured. Is it

like that? Is there any thing we need to do to over come this? Please

suggest.

Thanks,

Jamy

[Guest guest]

Hi Jamy:  That is good that your father has normal counts.  The fluid in the

eyes is a normal side effect of Gleevec.  I have had CML for 11 years, and that

is the one side effect that I deal with daily.  When the eyes swell, it does

look bad.  I use a cold compress on my eyes when I get up in the morning, and

it helps the swelling very well.  I still go through the runny eyes all day

long.  Fluid just keeps coming out once in awhile, and it looks like I am

crying.  I would not worry about that or any other side effects like foot

cramps which I get pretty bad sometimes.

    If he gets anything really unusual, then contact his doctor.  I hope he

continues to do well with his blood counts.

A.

From: Jamshid <jamshid98@...>

Subject: [ ] Fluid around the eyes.

Date: Saturday, April 24, 2010, 10:10 AM

 

Dear friends,

my father diagonalized CML and under Veenat(Gleevec) 300mg for the past 6

months. His blood counts looks normal after taking the drug. Now the main issue

is (besides pale skin) swelling around the eyes due to fluid and its quite

disturbance since eyes shrinks. But Doctor says its due to the side effects of

Gleevec and some time prescribed one Tablet but not cured. Is it like that? Is

there any thing we need to do to over come this? Please suggest.

Thanks,

Jamy

[Guest guest]

Hi Zavie,

The reason why doctor reduced the doze from 400mg to 300mg is bcoz of low WBC.

Some times back WBC count decreased when he was on 400 and and doctor changed it

to 300mg 3 months back and his WBC count set to normal after that.. Dr said he

cant reduce below 300 mg since it wont effect. I will ask the dr about sprycel

and tasigna.

Thanks a lot for ur reply.

Thx,

Jamy

________________________________

From: Zavie <zmiller@...>

Sent: Sat, April 24, 2010 8:02:11 PM

Subject: RE: [ ] Fluid around the eyes.

Hi Jamy,

Puffy eyes are a side effect of Gleevec. What we don't know here are the

side effects of Veenat. Veenat is a Generic Gleevec and it could be slightly

different than Gleevec. Pale skin is also a side effect of Gleevec.

The standard dose of Gleevec is 400 mg. Is there a reason that he is on 300

mg?

Ask his doctor if he access to some of the other CML drugs like Sprycel or

Tasigna. They work well for CML and may not have the same side effects as

Veenat.

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmillersympatico (DOT) ca

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

_____

From: groups (DOT) com [mailto:groups (DOT) com] On Behalf Of

Jamshid

Sent: April 24, 2010 10:10 AM

groups (DOT) com

Subject: [ ] Fluid around the eyes.

Dear friends,

my father diagonalized CML and under Veenat(Gleevec) 300mg for the past 6

months. His blood counts looks normal after taking the drug. Now the main

issue is (besides pale skin) swelling around the eyes due to fluid and its

quite disturbance since eyes shrinks. But Doctor says its due to the side

effects of Gleevec and some time prescribed one Tablet but not cured. Is it

like that? Is there any thing we need to do to over come this? Please

suggest.

Thanks,

Jamy

[Guest guest]

Hi Jamy,

Most CML specialists will not reduce the Gleevec. Instead they will halt the

medication until the WBC comes back into normal range and then restart the

Gleevec at 400 mg. When a patient receives a sub optimal dose of Gleevec

there is a danger that the patient will become resistant to the drug.

There is a situation where this is not true. It occurs when a lower dose of

Gleevec acts like a full dose of Gleevec. This can only be determined by

running a special test called a serum level test.

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

_____

From: [mailto: ] On Behalf Of

Jamshid

Sent: April 26, 2010 12:40 PM

Subject: Re: [ ] Fluid around the eyes.

Hi Zavie,

The reason why doctor reduced the doze from 400mg to 300mg is bcoz of low

WBC. Some times back WBC count decreased when he was on 400 and and doctor

changed it to 300mg 3 months back and his WBC count set to normal after

that.. Dr said he cant reduce below 300 mg since it wont effect. I will ask

the dr about sprycel and tasigna.

Thanks a lot for ur reply.

Thx,

Jamy

________________________________

From: Zavie <zmillersympatico (DOT) <mailto:zmiller%40sympatico.ca> ca>

groups (DOT) <mailto:%40> com

Sent: Sat, April 24, 2010 8:02:11 PM

Subject: RE: [ ] Fluid around the eyes.

Hi Jamy,

Puffy eyes are a side effect of Gleevec. What we don't know here are the

side effects of Veenat. Veenat is a Generic Gleevec and it could be slightly

different than Gleevec. Pale skin is also a side effect of Gleevec.

The standard dose of Gleevec is 400 mg. Is there a reason that he is on 300

mg?

Ask his doctor if he access to some of the other CML drugs like Sprycel or

Tasigna. They work well for CML and may not have the same side effects as

Veenat.

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmillersympatico (DOT) ca

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

_____

From: groups (DOT) com [mailto:groups (DOT) com] On Behalf Of

Jamshid

Sent: April 24, 2010 10:10 AM

groups (DOT) com

Subject: [ ] Fluid around the eyes.

Dear friends,

my father diagonalized CML and under Veenat(Gleevec) 300mg for the past 6

months. His blood counts looks normal after taking the drug. Now the main

issue is (besides pale skin) swelling around the eyes due to fluid and its

quite disturbance since eyes shrinks. But Doctor says its due to the side

effects of Gleevec and some time prescribed one Tablet but not cured. Is it

like that? Is there any thing we need to do to over come this? Please

suggest.

Thanks,

Jamy