RE: Re: pcr, ineed answers to

March 3, 2010

i have a little question, im sure you know more about this then me, what happens

wen the pcr is way lower then normal, natasha went to her doctor last month and

theysaid her pcr was only 0.03 i was all happy , thinking yes her blood is lower

now, but noooo its not good, they just continued her on her spycel and in 3

months she is supose to get cheque again, is there any thing els she is supose

to take , to try and put this pcr up again,

a worried mother,, thanks

From: kamykland@...

Date: Tue, 2 Mar 2010 08:16:41 -0800

Subject: Re: [ ] Re: pcr

and Bobby,

Dr. Druker did a FISH test for me 6 months ago at my one year bone marrow test.

Not sure why...maybe because at the same time he tested for Gleevec levels ---

I'll ask Carolyn and let you know. Kim

On Tue Mar 2nd, 2010 7:04 AM PST hey00nanc wrote:

>

>>

>> OK, I talked to my trial nurse today. My marrow pcr is 0.06. So it has gone

slightly up again. But she said the pcr of the blood is.0000. I am happy as

long as I am ccr, but am curious as to the difference in the two. Any help

there? She said the fish has not come back yet, and was surprised when I told

her I heard some drs don't even do fish anymore. Was I wrong?

>> I am at this moment waiting the arrival of my second great grand son. I have

many step great grand children, but only one other blood great grand child.

Michele is not quite 21, has worked full time as a hair dresser up until today

and goes to college full time. Will keep you posted, Bobby

>

>________________________

>

>Hi Bobby.....Gee Gee,

>Congrats on the new baby.....great grandchildren are proof that you have been

around the block a time or two!

>

>I think that marrow pcr is usually a bit larger than blood pcr...which is why

you usually stay with one of them and don't compare. As for the increase, I

think you are just seeing a normal variation that occurs when you are not a

solid zero.

>

>Dr. Druker has not done FISH as far as I know for a long time...which is why I

did not think it was used any more. FISH is not so highly accurate, and has the

false positives......and now that pcr testing is so easy to get and probably

more accurate, he relies on that.

>

>Bobby, I don't always keep up....are you bald at the moment! at least you have

a hairdresser in the family that can work with your 'do' as you let it grow back

in. Any photos?

>

> C.

>

_________________________________________________________________

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March 3, 2010

Dear Jeanny,

The PCR result of 0.03 is a good thing. The best PCR result would be

0.0000.

The PCR test measures the amount of CML Natasha has in her system. The goal

of treatment is for her not to have any.

Nothing to worry about. She is doing really well.

Zavie

Zavie (age 71)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 613-482-4801

Cell: 613-282-0204

ID: zaviem

Tel in FL: 561-429-5507

Re: [ ] Re: pcr

and Bobby,

Dr. Druker did a FISH test for me 6 months ago at my one year bone marrow

test. Not sure why...maybe because at the same time he tested for Gleevec

levels --- I'll ask Carolyn and let you know. Kim

On Tue Mar 2nd, 2010 7:04 AM PST hey00nanc wrote:

>

>>

>> OK, I talked to my trial nurse today. My marrow pcr is 0.06. So it has

gone slightly up again. But she said the pcr of the blood is.0000. I am

happy as long as I am ccr, but am curious as to the difference in the two.

Any help there? She said the fish has not come back yet, and was surprised

when I told her I heard some drs don't even do fish anymore. Was I wrong?

>> I am at this moment waiting the arrival of my second great grand son.

>> I have many step great grand children, but only one other blood great

>> grand child. Michele is not quite 21, has worked full time as a hair

>> dresser up until today and goes to college full time. Will keep you

>> posted, Bobby

>

>________________________

>

>Hi Bobby.....Gee Gee,

>Congrats on the new baby.....great grandchildren are proof that you have

been around the block a time or two!

>

>I think that marrow pcr is usually a bit larger than blood pcr...which is

why you usually stay with one of them and don't compare. As for the

increase, I think you are just seeing a normal variation that occurs when

you are not a solid zero.

>

>Dr. Druker has not done FISH as far as I know for a long time...which is

why I did not think it was used any more. FISH is not so highly accurate,

and has the false positives......and now that pcr testing is so easy to get

and probably more accurate, he relies on that.

>

>Bobby, I don't always keep up....are you bald at the moment! at least you

have a hairdresser in the family that can work with your 'do' as you let it

grow back in. Any photos?

>

> C.

>

_________________________________________________________________

Live connected with Messenger on your phone

http://go.microsoft.com/?linkid=9712958

March 3, 2010

I cant believe that Natasha's dr has not explained this to you

Her PCR is wonderful. Mine is 0. You want to be low and yes she has to

stay on the Sprycel as we all have to stay on either gleevic, sprycel or

Tasigna. If you stop you run the risk of your PCR going up. 0 pcr means

there are no cancer cells detected in your blood. GOOD NEWS!!!

AS far as I know there is no normal pcr. I would say 0 is normal. I bet

when she goes again in 3 months she will be at 0%.....I hope I am

understanding your question correctly.

I too get checked every 3 months.

Sharon T

Re: [ ] Re: pcr

and Bobby,

Dr. Druker did a FISH test for me 6 months ago at my one year bone marrow

test. Not sure why...maybe because at the same time he tested for Gleevec

levels --- I'll ask Carolyn and let you know. Kim

On Tue Mar 2nd, 2010 7:04 AM PST hey00nanc wrote:

>

>>

>> OK, I talked to my trial nurse today. My marrow pcr is 0.06. So it has

gone slightly up again. But she said the pcr of the blood is.0000. I am

happy as long as I am ccr, but am curious as to the difference in the two.

Any help there? She said the fish has not come back yet, and was surprised

when I told her I heard some drs don't even do fish anymore. Was I wrong?

>> I am at this moment waiting the arrival of my second great grand son. I

have many step great grand children, but only one other blood great grand

child. Michele is not quite 21, has worked full time as a hair dresser up

until today and goes to college full time. Will keep you posted, Bobby

>

>________________________

>

>Hi Bobby.....Gee Gee,

>Congrats on the new baby.....great grandchildren are proof that you have

been around the block a time or two!

>

>I think that marrow pcr is usually a bit larger than blood pcr...which is

why you usually stay with one of them and don't compare. As for the

increase, I think you are just seeing a normal variation that occurs when

you are not a solid zero.

>

>Dr. Druker has not done FISH as far as I know for a long time...which is

why I did not think it was used any more. FISH is not so highly accurate,

and has the false positives......and now that pcr testing is so easy to get

and probably more accurate, he relies on that.

>

>Bobby, I don't always keep up....are you bald at the moment! at least you

have a hairdresser in the family that can work with your 'do' as you let it

grow back in. Any photos?

>

> C.

>

_________________________________________________________________

Live connected with Messenger on your phone

http://go.microsoft.com/?linkid=9712958

March 3, 2010

Jeanny, the pcr is supposed to be low. Are you sure you are talking about pcr

and not another blood count, perhaps ANC, absolute neutrophil count? That is

not supposed to go way low, below 1.00, but the lower the pcr, the better for

the patient. All these labs and their meaning are very confusing, but there are

experts here that can ease your mind.

Maybe you could post her last labs? Bobby

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

11/2009 PCR 0.034

#840 Zavie's Zero Club