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Resistance & side effects

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Article Date: 01 Mar 2010

" Huixin He, associate professor of nanoscale chemistry at Rutgers University,

Newark, and Tamara Minko, professor at the Rutgers Ernest School of

Pharmacy, have developed a nanotechnology approach that could potentially

eliminate the problems of side effects and drug resistance in the treatment of

cancer. Under traditional chemotherapy, cancer cells, like bacteria, can develop

resistance to drug therapy, leading to a relapse of the disease.

" As reported in the December 21, 2009, issue of the journal Small, He, Minko and

their co-researchers, including investigators from Merck & Co. and Carl Zeiss

SMT, a global nanotechnology firm, have designed nanomaterials that allow for

the delivery of both a chemical (doxorubicin) to destroy cancer cells and a

genetic drug to prevent drug resistance.

" When administered to drug-resistant ovarian cancer cells, the treatment was

more than 130 times lethal than when doxorubicin was administrated alone. " The

drug can only be released when it is inside the cancer cells, " He said. " This

controlled internal release mechanism can dramatically eliminate side effects

associated with anticancer drugs to normal tissues. "

More on this subject at this website:

http://www.medicalnewstoday.com/articles/180586.php

FYI,

Lottie Duthu

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