RE: Re: pcr, ineed answers to, i did a mistake, sorry

March 4, 2010

sorry about that,, my daughter is here with me, and she said i did a mistake,

it was 2.7 and it is supose to be a 3 or more, and he said he was worried about

that, i really dont understand

From: rcd1929@...

Date: Wed, 3 Mar 2010 07:35:45 -0800

Subject: RE: [ ] Re: pcr, ineed answers to

Jeanny, the pcr is supposed to be low. Are you sure you are talking about pcr

and not another blood count, perhaps ANC, absolute neutrophil count? That is

not supposed to go way low, below 1.00, but the lower the pcr, the better for

the patient. All these labs and their meaning are very confusing, but there are

experts here that can ease your mind.

Maybe you could post her last labs? Bobby

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

11/2009 PCR 0.034

#840 Zavie's Zero Club

>

>>

>> OK, I talked to my trial nurse today. My marrow pcr is 0.06. So it has gone

slightly up again. But she said the pcr of the blood is.0000. I am happy as

long as I am ccr, but am curious as to the difference in the two. Any help

there? She said the fish has not come back yet, and was surprised when I told

her I heard some drs don't even do fish anymore. Was I wrong?

>> I am at this moment waiting the arrival of my second great grand son. I have

many step great grand children, but only one other blood great grand child.

Michele is not quite 21, has worked full time as a hair dresser up until today

and goes to college full time. Will keep you posted, Bobby

>

>________________________

>

>Hi Bobby.....Gee Gee,

>Congrats on the new baby.....great grandchildren are proof that you have been

around the block a time or two!

>

>I think that marrow pcr is usually a bit larger than blood pcr...which is why

you usually stay with one of them and don't compare. As for the increase, I

think you are just seeing a normal variation that occurs when you are not a

solid zero.

>

>Dr. Druker has not done FISH as far as I know for a long time...which is why I

did not think it was used any more. FISH is not so highly accurate, and has the

false positives......and now that pcr testing is so easy to get and probably

more accurate, he relies on that.

>

>Bobby, I don't always keep up....are you bald at the moment! at least you have

a hairdresser in the family that can work with your 'do' as you let it grow back

in. Any photos?

>

> C.

>

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March 4, 2010

Hi , I think you and your daughter may have misunderstood your doctor. A

PCR shows the percentage of leukemic cells in your marrow, or blood, and the

lower the number, the fewer cells there are. for instance, when I entered the

trial I am in I began with a PCR of 5.69. It went from there to 0.017, to

0.03. They are terrific numbers, as they are way down from 5.69. My last labs

were, white blood count - 6.6; hemoglobin - 10.6, hematocrit 31.9; platelet

count 179, Absolute Neutrophil Count - 4.8. These counts are normal for me, and

I would think normal for the average person with CML, on Gleevec, or Sprycel or

whatever they are taking. The PCR is taken from the bone marrow, or from the

blood, and believe me, you want this number to be LOW as possible, you do not

want it to go up. I am sure others could explain this to you better than me, and

they will chip in here and advise you. This is truly a learning experience, and

the more people

that can give you their advice or experiences, the better. Good luck, Bobby