Re: pcr, ineed answers to, i did a mistake, sorry

[Guest guest]

Hi Jeaney: You better recheck what number the doctor is referring to.

As Zavie and others have said, you want the PCR to read 0.0000. I think it

might be another figure that you are mxed up about.

Just ask them to explain it clearly to you, and always get a copy of any blood

work or test that any doctor does. Keep your own file.

Hope your daughter is doing well.

A.

> >>

> >> OK, I talked to my trial nurse today. My marrow pcr is 0.06. So it has

gone slightly up again. But she said the pcr of the blood is.0000. I am happy

as long as I am ccr, but am curious as to the difference in the two. Any help

there? She said the fish has not come back yet, and was surprised when I told

her I heard some drs don't even do fish anymore. Was I wrong?

> >> I am at this moment waiting the arrival of my second great grand son. I

have many step great grand children, but only one other blood great grand child.

Michele is not quite 21, has worked full time as a hair dresser up until today

and goes to college full time. Will keep you posted, Bobby

> >

> >________________________

> >

> >Hi Bobby.....Gee Gee,

> >Congrats on the new baby.....great grandchildren are proof that you have been

around the block a time or two!

> >

> >I think that marrow pcr is usually a bit larger than blood pcr...which is why

you usually stay with one of them and don't compare. As for the increase, I

think you are just seeing a normal variation that occurs when you are not a

solid zero.

> >

> >Dr. Druker has not done FISH as far as I know for a long time...which is why

I did not think it was used any more. FISH is not so highly accurate, and has

the false positives......and now that pcr testing is so easy to get and probably

more accurate, he relies on that.

> >

> >Bobby, I don't always keep up....are you bald at the moment! at least you

have a hairdresser in the family that can work with your 'do' as you let it grow

back in. Any photos?

> >

> > C.

> >

> >

> >

>

>

> __________________________________________________________

> Live connected with Messenger on your phone

> http://go.microsoft.com/?linkid=9712958

>

>

[Guest guest]

Hi Jeanny

I agree with other responders to your post. PCR is a very sensitive test that

looks to see how much of the leukaemia there is. You want it to be as low as

possible, preferably zero. In my case, it started at 83.0 before treatment, then

went to 3.6, then 0.06 and now it is 0.000.  Which is what everyone wants to

see.  I won't speculate on what the 3 number is but it sounds like a primary

blood count to me.  It could be WBC (your white blood count the lower end of

which I think is considered to be 3 by some labs at least) - this is the one

that is usually far too high (in the 100s) when diagnosed.  It can drop below

the lower end of normal on treatment - mine got close - although it typically

recovers. Your doctor can advise you better than I but my immediate reaction is

not to worry. 2.7 is close to 3 and I'm told that what really matters is your

absolute neutrophil count, which is normally above 2 but they don't worry until

it is below 1 (quite a

few CML patients on Gleevec have neutrophil counts between 1 and 2: mine went

below 2 at first then recovered and is fine now).

Bottom line - this doesn't sound like PCR at all but also doesn't seem too

worrying at first sight. Best speak to your daughter's doctor again though.

________________________________

From: jeanny forest <jeanny-f@...>

" " < >

Sent: Thu, March 4, 2010 1:42:01 AM

Subject: RE: [ ] Re: pcr, ineed answers to, i did a mistake, sorry

sorry about that,, my daughter is here with me, and she said i did a mistake, it

was 2.7 and it is supose to be a 3 or more, and he said he was worried about

that, i really dont understand

From: rcd1929@...

Date: Wed, 3 Mar 2010 07:35:45 -0800

Subject: RE: [ ] Re: pcr, ineed answers to

 

Jeanny, the pcr is supposed to be low.  Are you sure you are talking about pcr

and not another blood count, perhaps ANC, absolute neutrophil count?  That is

not supposed to go way low, below 1.00, but the lower the pcr, the better for

the patient. All these labs and their meaning are very confusing, but there are

experts here that can ease your mind.

Maybe you could post her last labs?  Bobby

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

11/2009 PCR 0.034

#840 Zavie's Zero Club

>

>

>

>>

>> OK, I talked to my trial nurse today.  My marrow pcr is 0.06.  So it has gone

slightly up again.  But she said the pcr of the blood is.0000.  I am happy as

long as I am ccr, but am curious as to the difference in the two.  Any help

there?  She said the fish has not come back yet, and was surprised when I told

her I heard some drs don't even do fish anymore.  Was I wrong?

>> I am at this moment waiting the arrival of my second great grand son.  I have

many step great grand children, but only one other blood great grand child. 

Michele is not quite 21, has worked full time as a hair dresser up until today

and goes to college full time.  Will keep you posted, Bobby

>

>________________________

>

>Hi Bobby.....Gee Gee,

>Congrats on the new baby.....great grandchildren are proof that you have been

around the block a time or two!

>

>I think that marrow pcr is usually a bit larger than blood pcr...which is why

you usually stay with one of them and don't compare. As for the increase, I

think you are just seeing a normal variation that occurs when you are not a

solid zero.

>

>Dr. Druker has not done FISH as far as I know for a long time...which is why I

did not think it was used any more. FISH is not so highly accurate, and has the

false positives......and now that pcr testing is so easy to get and probably

more accurate, he relies on that.

>

>Bobby, I don't always keep up....are you bald at the moment! at least you have

a hairdresser in the family that can work with your 'do' as you let it grow back

in. Any photos?

>

> C.

>

>

>

                         

__________________________________________________________

Live connected with Messenger on your phone

http://go.microsoft.com/?linkid=9712958

[Guest guest]

> sorry about that,, my daughter is here with me, and she said i did a mistake,

it was 2.7 and it is supose to be a 3 or more, and he said he was worried about

that, i really dont understand

________________________________

Hi Jeanny,

I think you are talking about a blood count (not prc), maybe it is the white

count. I think both you and your daughter should spend a bit more time talking

to the doctor, or his nurse....and they should explain things to you so you

understand. You have a right to expect that. You need to have a good working

relationship with her doctor.

I do not remember how old your daughter is (I think she is independent?)......so

she could also do this alone, but she needs to understand all the counts well

enough so that she can explain them to you. If you can also go to her

appointments, then the doctor can explain to both of you. You don't want to be

always in the dark about what the numbers mean. This is what I would suggest.

C.