RES: Re: Who Can help me

[Guest guest]

Hi tracey, thank you for your answer.

At the begin the lab showed only BCR-ABL transcript. From the last 2 results

now show b3a2 and b2a2 transcripts

Below my results; according the international scaling

Jun/09

Bcr/abl = 0,049 %

Aug/09

Bcr/abl = 0,039%

Nov/09

Bcr/abl (b2a2) = 0,0024 %

Bcr/abl (b3a2) = 0,004%

Mar/10

Bcr/abl (b2a2) = undetectable

Bcr/abl (b3a2) = 0,097%

References:

Decrease 1 log: 10%

Decrease 2 log: 1%

Decrease 3 log: 0,1 %

Decrease 4 log: 0,01%

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De: [mailto: ] Em nome de

traceyincanada

Enviada em: segunda-feira, 5 de abril de 2010 23:08

Para:

Assunto: [ ] Re: Who Can help me

Hi Ciro,

Do you have a previous test done from the same lab that can be used to

compare or was this the first test you had and they are using their baseline

to come up with the numbers? Or is it possible that the result is a 1.5 log

reduction and not a 1.5 log increase?

Did you always have the b2a2 transcript and now is the first time it's

undetectable or is it possible that you never had that transcript before?

Not everyone has both transcripts, in fact very few do but to answer your

question yes it is possible to have very different values for the two.

If I were you, I'd have another test as soon as possible to confirm the

results from this one and if the increase is still there I'd have a mutation

test to see if there's a mutation present that would respond better to one

of the newer drugs.

Try not to panic, there are many options out there if this does turn out to

be a real increase.

Tracey

>

>

> I just received my last PCR test.

> But my labs shows tho results, according Internationa Scaling b2a2 and

b3a2 transcripts.

> B2a2 went to undetectable, nice... but the other b3a2 increased 1,5 log

!!!!

> Is this possibile one transcript goes to ZERO and other increased ??

>

> I´m very worried and would be very grateful if anyone can help me to

undertand this results.

>

> Ciro

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