Possible allergie to gleevec?

[Guest guest]

Hi, I used to post on here quite a bit. My wife Beth has had CML for over two

years now and has been doing great on Gleevec. She reached total remission in

less than 6 months. recently she has been having episodes of vomiting after

taking her nightly dose but it only happens about every other week or so. The

last time she also had a slight rash develop on her neck. I'm wondering if any

one else has had a similar experiance in the past. Does it look like she may be

developing an allergie to the gleevec. We hate this idea just because the

Gleevec has worked so well the thought of having to come off it is pretty scarey

to us. Any ideas?

[Guest guest]

You said she takes a nightly dose?  Does she lie down right away, or wait a

while?  You should not lie down right after taking Gleevec, but if she doesn't,

then I don't know what it could be.  I doubt she would be allergic after two

years, but check with her dr.  Good luck, and don't let a rash get ahead of

itself, they can be the devil to get rid of.  bobby

a ( Bobby ) Doyle, dob 12/17/29

Brecksville, Ohio, USA

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.017

11/2009 PCR 0.034

#840 Zavie's Zero Club

From: monkeyfun_16901 <monkeyfun_16901@...>

Subject: [ ] Possible allergie to gleevec?

Date: Wednesday, April 21, 2010, 7:31 AM

 

Hi, I used to post on here quite a bit. My wife Beth has had CML for over

two years now and has been doing great on Gleevec. She reached total remission

in less than 6 months. recently she has been having episodes of vomiting after

taking her nightly dose but it only happens about every other week or so. The

last time she also had a slight rash develop on her neck. I'm wondering if any

one else has had a similar experiance in the past. Does it look like she may be

developing an allergie to the gleevec. We hate this idea just because the

Gleevec has worked so well the thought of having to come off it is pretty scarey

to us. Any ideas?

[Guest guest]

The rash is probably associated with the vomiting. When we vomit, it's common

to break little tiny capillaries and/or become flushed. Does the rash resolve

after some time? If so, then I highly doubt it would be an allergy. If she was

truly allergic to the Gleevec, she wouldn't get any relief since she takes the

drug daily. The rash would just get worse.

I used to vomit after taking my dose until I realized that I wasn't drinking

enough water with the pill. When I increased my water to at least 6 oz, I

noticed the nausea was cut down tremendously.

I would suggest that she try eating more food to cushion the stomach and drink

an entire glass of water when taking the pill. Hope that helps.

Tracey

dx Jan 2002

>

> Hi, I used to post on here quite a bit. My wife Beth has had CML for over two

years now and has been doing great on Gleevec. She reached total remission in

less than 6 months. recently she has been having episodes of vomiting after

taking her nightly dose but it only happens about every other week or so. The

last time she also had a slight rash develop on her neck. I'm wondering if any

one else has had a similar experiance in the past. Does it look like she may be

developing an allergie to the gleevec. We hate this idea just because the

Gleevec has worked so well the thought of having to come off it is pretty scarey

to us. Any ideas?

>