Gleveec + Zileuton at UMass

[Guest guest]

Hi Everyone,

I inquired about this trial and got the following information via a telephone

conversation with Dr Cerny:

We talked for a lengthy amount of time about how the trial was going to work and

when it was going to start.

They currently have one patient enrolled in the Phase I trial and plan on

ramping up to 15. They plan on starting everyone one on a minimum dose of

Zileuton and 400 mg (I guess they are assuming standard dose) of Gleevec and

monitor every two weeks. As the patient shows tolerance for the drugs, they will

increase to a medium dose. They will continue to monitor and if the patient

shows tolerance for the medium dose, they will increase to the maximum dose.

They will stop the patient at the level they can tolerate.

Patients will be monitored by PCR's and other methods (don't know what they are

but they must be new and awaiting patents). The concentration level of the drugs

will be monitored for each patient.

You will not be required to do a BMB unless it is your annual (or whatever time

period you have agreed to with your local onc), or you request one.

Dr Cerny's team is already in discussion about testing Sprycel (and other TKI's)

and Zileuton as the next step. Of course they have to prove their concept first

with Gleevec.

Dr Cerny has agreed to call me back with additional information in the next

couple of days. I will post any new info I get.

http://www.unav.es/ciencias/estudios/doctorado/articulos/Naturegenetics09def.pdf

I hope this information is useful.

Warmest regards,

Don