RE: Follow Up on Question About PPI's

[Guest guest]

Hi Pat,

What kind of an oncologist do you have? One of the best known and most

understood side effect of Gleevec is GI upset. I have never heard of any doctor

denying that. The question remains however, how to treat it.

Judging by the few responses we got here and the little bit of information I

found on the net (I haven't had time to dig really deep yet), it would appear

that the PPI's probably are safe to use with Gleevec.

Here is one article that looks supportive:

http://tinyurl.com/23q6yqo

Tracey

>

> Hi all -

> Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> ago that Gleevec must be exposed to an acidic environment in order to be

> metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

>

> I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

>

> Thanks,

> Pat in Phoenix

>

[Guest guest]

Thanks, Tracey, this is very helpful. I have a hematologist who prescribed

protonix which the insurance company denied and they then forced a prescription

change (after a six week battle) to omeprazole which carries a warning to not

take for more than for a 14-day period and no more often than once every four

months. I saw the physician assistant at my last visit and asked whether it was

safe to take the omeprazole daily, he asked about the symptoms and then made his

pronoucement about it not being Gleevec and needing a gastro appointment. All of

this is, of course, very frustrating.

> >

> > Hi all -

> > Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> > ago that Gleevec must be exposed to an acidic environment in order to be

> > metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

> >

> > I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

> >

> > Thanks,

> > Pat in Phoenix

> >

>

[Guest guest]

I am not part of your group but I was havng a awful time waking up with acid

relux  and I have a small hiatel hernia.  My gi drs and onc. gave me aciphex

to take in the mornings cause I take the gleevec later.  I dont take it all the

time, just when I need it.  Just my 2 cents worth.

                   Dee145

________________________________

From: phoenixpat <phoenixpat@...>

Sent: Thu, June 3, 2010 11:30:29 AM

Subject: [ ] Re: Follow Up on Question About PPI's

 

Thanks, Tracey, this is very helpful. I have a hematologist who prescribed

protonix which the insurance company denied and they then forced a prescription

change (after a six week battle) to omeprazole which carries a warning to not

take for more than for a 14-day period and no more often than once every four

months. I saw the physician assistant at my last visit and asked whether it was

safe to take the omeprazole daily, he asked about the symptoms and then made his

pronoucement about it not being Gleevec and needing a gastro appointment. All of

this is, of course, very frustrating.

> >

> > Hi all -

> > Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> > ago that Gleevec must be exposed to an acidic environment in order to be

> > metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

> >

> > I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

> >

> > Thanks,

> > Pat in Phoenix

> >

>

[Guest guest]

I am no longer on Gleevec, but when I was it was acceptable to take Prevacid,

but as I remember, not within two hours of taking Gleevec,  Bobby

a ( Bobby ) Doyle, dob 12/17/29

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.01

11/2009 PCR 0.034

02/2010 PCRU

#840 Zavie's Zero Club

From: traceyincanada <traceyincanada@...>

Subject: [ ] Re: Follow Up on Question About PPI's

Date: Thursday, June 3, 2010, 10:05 AM

 

Hi Pat,

What kind of an oncologist do you have? One of the best known and most

understood side effect of Gleevec is GI upset. I have never heard of any doctor

denying that. The question remains however, how to treat it.

Judging by the few responses we got here and the little bit of information I

found on the net (I haven't had time to dig really deep yet), it would appear

that the PPI's probably are safe to use with Gleevec.

Here is one article that looks supportive:

http://tinyurl.com/23q6yqo

Tracey

>

> Hi all -

> Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> ago that Gleevec must be exposed to an acidic environment in order to be

> metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

>

> I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

>

> Thanks,

> Pat in Phoenix

>

[Guest guest]

Omeprazole has a nasty side effect with some people, like me, severe gas!! 

Prevacid does not, and neither did Prilosec, which is supposed to be the same as

Omeprazole.  Bobby

a ( Bobby ) Doyle, dob 12/17/29

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.01

11/2009 PCR 0.034

02/2010 PCRU

#840 Zavie's Zero Club

From: phoenixpat <phoenixpat@...>

Subject: [ ] Re: Follow Up on Question About PPI's

Date: Thursday, June 3, 2010, 11:30 AM

 

Thanks, Tracey, this is very helpful. I have a hematologist who prescribed

protonix which the insurance company denied and they then forced a prescription

change (after a six week battle) to omeprazole which carries a warning to not

take for more than for a 14-day period and no more often than once every four

months. I saw the physician assistant at my last visit and asked whether it was

safe to take the omeprazole daily, he asked about the symptoms and then made his

pronoucement about it not being Gleevec and needing a gastro appointment. All of

this is, of course, very frustrating.

> >

> > Hi all -

> > Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> > ago that Gleevec must be exposed to an acidic environment in order to be

> > metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

> >

> > I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

> >

> > Thanks,

> > Pat in Phoenix

> >

>

[Guest guest]

Hi Pat:  These insurance companies make me crazy.  I do not need referrals

with my insurance, but I would insist on a referral.  If you need a

Gastroenterologist to run some tests on you to find the cause of this

indigestion they have to let you go to a specialist.

Fight it and appeal their decision.  They will give it to you if your doctor

says that  he feels you need further testing.  Gleevec does cause GERD.

From: phoenixpat <phoenixpat@...>

Subject: [ ] Follow Up on Question About PPI's

Date: Thursday, June 3, 2010, 12:48 AM

 

Hi all -

Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI since

it reduces the acid content of the stomach. "

I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

Thanks,

Pat in Phoenix

[Guest guest]

Hi Dee:  You should join our group here at .  We have a group of very good

people here, and always ready to help you out with whatever is bothering you. 

You can be part of any boards to post and help or get help anytime.

     Gleevec does cause Acid Reflux.  Glad your taking something for it.

A.

From: Dee <dallen145@...>

Subject: Re: [ ] Re: Follow Up on Question About PPI's

Date: Thursday, June 3, 2010, 11:44 AM

 

I am not part of your group but I was havng a awful time waking up with acid

relux  and I have a small hiatel hernia.  My gi drs and onc. gave me aciphex

to take in the mornings cause I take the gleevec later.  I dont take it all the

time, just when I need it.  Just my 2 cents worth.

                   Dee145

________________________________

From: phoenixpat <phoenixpat@...>

Sent: Thu, June 3, 2010 11:30:29 AM

Subject: [ ] Re: Follow Up on Question About PPI's

 

Thanks, Tracey, this is very helpful. I have a hematologist who prescribed

protonix which the insurance company denied and they then forced a prescription

change (after a six week battle) to omeprazole which carries a warning to not

take for more than for a 14-day period and no more often than once every four

months. I saw the physician assistant at my last visit and asked whether it was

safe to take the omeprazole daily, he asked about the symptoms and then made his

pronoucement about it not being Gleevec and needing a gastro appointment. All of

this is, of course, very frustrating.

> >

> > Hi all -

> > Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> > ago that Gleevec must be exposed to an acidic environment in order to be

> > metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

> >

> > I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

> >

> > Thanks,

> > Pat in Phoenix

> >

>

[Guest guest]

Hi Bobby:  Nobody ever told me not to take my Nexium within a certain length of

time between my Gleevec.  Maybe I am doing something wrong, but have had no

problems at all like I did before.  Because all my meds are to be taken once a

day, I take everything together with a good breakfast and water.  This way its

all done for the day.  It helps me not to forget anything too.  I suffered so

bad with GERD, and started to have errosion in the esophagus from the Gleevec,

and the Nexium has been great.  I am also on it for a few years now, even

though they say you should not take it long term.  None of my doctors have told

me to stop it etc.  Hope this helps somebody else out with the same problem.

A.

From: traceyincanada <traceyincanada@...>

Subject: [ ] Re: Follow Up on Question About PPI's

Date: Thursday, June 3, 2010, 10:05 AM

 

Hi Pat,

What kind of an oncologist do you have? One of the best known and most

understood side effect of Gleevec is GI upset. I have never heard of any doctor

denying that. The question remains however, how to treat it.

Judging by the few responses we got here and the little bit of information I

found on the net (I haven't had time to dig really deep yet), it would appear

that the PPI's probably are safe to use with Gleevec.

Here is one article that looks supportive:

http://tinyurl.com/23q6yqo

Tracey

>

> Hi all -

> Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> ago that Gleevec must be exposed to an acidic environment in order to be

> metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

>

> I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

>

> Thanks,

> Pat in Phoenix

>

[Guest guest]

Hi Pat

I have horrible acid and reflux. I take previcid for it and it really makes a

big difference. The over the counter stuff does nothing for me. My GP is the one

who prescibed, not the oncologist. I have been on Gleevec for a little over 2

years since the CML started to resurface about 3 years ago and following a BM

transplant 15 years ago.

I just came back from my bi annual check up a couple of hours ago and found that

all is working the way it is suppose to. So previcid has had no adverse effect

on the Gleevec as far as my condition is concerned.

Walt

________________________________

From: phoenixpat <phoenixpat@...>

Sent: Thu, June 3, 2010 12:48:07 AM

Subject: [ ] Follow Up on Question About PPI's

Hi all -

Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI since

it reduces the acid content of the stomach. "

I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

Thanks,

Pat in Phoenix

[Guest guest]

Hi Pat.

Sorry I don't use Previcid..that did not work for me. I use Nexium and have for

a couple years. I take it in the AM just before breakfast.

Walt

________________________________

From: phoenixpat <phoenixpat@...>

Sent: Thu, June 3, 2010 12:48:07 AM

Subject: [ ] Follow Up on Question About PPI's

Hi all -

Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI since

it reduces the acid content of the stomach. "

I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

Thanks,

Pat in Phoenix

[Guest guest]

Hi Pat,

I can sympathize with you re the digestive issues! I was officially dx with

inflammatory bowel disease in 2002 after years of problems, then when I was

on Glivec, it actually helped the symptoms. I have been on Tasigna for just

on 2 years and it has now progressed to Crohn's and also caused a stomach

ulcer, because of the acid environment. I am now taking Mesalazine as well

to try and control it with intermittent doses of Flagyl and have avoided

prednisolone so far. Another friend who is on Glivec has just been dx with

lymphocytic colitis with one of the treatments being Mesalazine. It is no

fun and it is appalling your Dr won't listen to you! I also have at a

minimum yearly top and bottom scopes to keep tabs on it all. I hope you can

get your referral ASAP.

Regards,

From: [mailto: ] On Behalf Of

phoenixpat

Sent: Thursday, 3 June 2010 2:48 PM

Subject: [ ] Follow Up on Question About PPI's

Hi all -

Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary.

I need some expert advice that I can use to either battle the insurance

company or take back to the oncologist...and, more than anything, I really

need some relief from this!

Thanks,

Pat in Phoenix

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[Guest guest]

I have been diagnosised with Barrett's Esophagus (it does run in my famiy)and

take Omeprazole twice a day 30 minutes before my meal. I had no problems with

taking 400mg Gleevec at the same time. Nothing was ever said about seperating

it from the time I took Gleevec.

H.

>

> Hi all -

> Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> ago that Gleevec must be exposed to an acidic environment in order to be

> metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

>

> I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

>

> Thanks,

> Pat in Phoenix

>

[Guest guest]

I too have sporadic bad reflux and esophagus problems, so my consultant told me

to take low dose omeprazole which I am told by many is oK with Gleevec. I do

stop from time to time - when it seems under control - but as soon as it shows

signs of returning, I start again - and it works. There has been no effect on

my use of Gleevec. I think it's Dasatinib you cant take antacids with but the

docs can advise.

> >

> > Hi all -

> > Is anyone in the group in contact with an expert who can help with Tracey's

question and comment - " There was some speculation a while

> > ago that Gleevec must be exposed to an acidic environment in order to be

> > metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach. "

> >

> > I'm personally having horrid digestive issues and my oncologist says it has

nothing to do with Gleevec and asked for a referral to a gastroenterologist.

Meanwhile the insurance company is holding up the referral as not necessary. I

need some expert advice that I can use to either battle the insurance company or

take back to the oncologist...and, more than anything, I really need some relief

from this!

> >

> > Thanks,

> > Pat in Phoenix

> >

>