Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 Hello, My son has IgG Subclass def. He is Ig1 and Ig2 deficient. (Leave it to us to have the most common and the most rare forms!) As I understand it, Ig2 is the most common. Here is what I found on the internet. Because IgG2 is important in response to polysaccharides, encapsulated bacteria (eg, H influenzae type b, S pneumoniae) are common causes of infection in these patients. Antibodies reactive with bacterial cell wall antigens are thought to be predominantly of the IgG2 isotype. Patients may be unable to produce specific antibodies after immunization with purified polysaccharide antigens (eg, pneumococcal vaccine polyvalent [Pneumovax]). More than 10% of these patients also present with dermal or visceral vasculitis. This makes sense because my son had problems with colds, brochitis, flus, more lung and sinus related issues. Several drs thought he had asthma. He also does not make responses to polysccharide vaccines. Hope this helps some. @...: momof2withga2@...: Thu, 11 Dec 2008 09:53:01 -0800Subject: Subclass 2 deficiency Hi all, We just found out that our little one has a subclass 2 deficiency. We haven't yet talked to the immunologist as these results were passed on by the geneticist.Does anyone know what this means?Best Regards,Krystena sAmbassador, United Mitochondrial Disease Foundationhttp://www.umdf.org/site/c.dnJEKLNqFoG/b.3041929/Region 4 " Genetics Care Coordation " phone:859-749-7366fax:859-499-3477[Non-text portions of this message have been removed] _________________________________________________________________ Send e-mail faster without improving your typing skills. http://windowslive.com/Explore/hotmail?ocid=TXT_TAGLM_WL_hotmail_acq_speed_12200\ 8 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 A really simplified version would be: If your son's Immunoglobulins were a soccer team -- he's missing all his mid-fielders and the other players are having to run farther and cover more territory. They may or may not be able to " cover " adequately. It is thought that some people have low IgG subclasses and the body adequately covers. The way to check and see if everything is covered is #1 to check the titers to vaccinations to make sure that the other IgG's have built an adequate response. If they have not - -then he will need IgG replacement. #2 looking at the clinical picture -- if the other IgG's are exhausted and not covering well, he may qualify for IgG replacement in order to give his body a break from the constant infections. Hope that helps to picture what is happening. I believe someone else sent you the technical response. In this group -- you can get both. It helps me to have a visual picture of what's going on! May God bless you as you continue in the diagnostic process. In His service, dale Krystena s wrote: > > > Hi all, > > We just found out that our little one has a subclass 2 deficiency. We > haven't yet talked to the immunologist as these results were passed on > by the geneticist. > Does anyone know what this means? > > Best Regards, > Krystena s > Ambassador, United Mitochondrial Disease Foundation > http://www.umdf.org/site/c.dnJEKLNqFoG/b.3041929/ > <http://www.umdf.org/site/c.dnJEKLNqFoG/b.3041929/> > Region 4 " Genetics Care Coordation " > phone:859-749-7366 > fax:859-499-3477 > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 Thanks for the great explanation. I also found some of the things you said online. Would this possibly account for my sons very high fever with his baby shots last week? He has now had 10 ear infections. Currently had one plus a sinus infection. How do you know whether to blame neutrophils or Igg levels for infections? Best Regards, Krystena s Ambassador, United Mitochondrial Disease Foundation http://www.umdf.org/site/c.dnJEKLNqFoG/b.3041929/ Region 4 " Genetics Care Coordation " phone:859-749-7366 fax:859-499-3477 From: laura smith <iamlaurasmith@...> Subject: RE: Subclass 2 deficiency " healyh " < > Date: Thursday, December 11, 2008, 3:53 PM Hello, My son has IgG Subclass def. He is Ig1 and Ig2 deficient. (Leave it to us to have the most common and the most rare forms!) As I understand it, Ig2 is the most common. Here is what I found on the internet. Because IgG2 is important in response to polysaccharides, encapsulated bacteria (eg, H influenzae type b, S pneumoniae) are common causes of infection in these patients. Antibodies reactive with bacterial cell wall antigens are thought to be predominantly of the IgG2 isotype. Patients may be unable to produce specific antibodies after immunization with purified polysaccharide antigens (eg, pneumococcal vaccine polyvalent [Pneumovax]) . More than 10% of these patients also present with dermal or visceral vasculitis. This makes sense because my son had problems with colds, brochitis, flus, more lung and sinus related issues. Several drs thought he had asthma. He also does not make responses to polysccharide vaccines. Hope this helps some. groups (DOT) comFrom: momof2withga2Date: Thu, 11 Dec 2008 09:53:01 -0800Subject: Subclass 2 deficiency Hi all, We just found out that our little one has a subclass 2 deficiency. We haven't yet talked to the immunologist as these results were passed on by the geneticist.Does anyone know what this means?Best Regards,Krystena sAmbassador, United Mitochondrial Disease Foundationhttp: //www.umdf. org/site/ c.dnJEKLNqFoG/ b.3041929/ Region 4 " Genetics Care Coordation " phone: 859-749-7366fax: 859-499-3477[ Non-text portions of this message have been removed] ____________ _________ _________ _________ _________ _________ _ Send e-mail faster without improving your typing skills. http://windowslive. com/Explore/ hotmail?ocid= TXT_TAGLM_ WL_hotmail_ acq_speed_ 122008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 's illnesses were not major. Ear infections, cold, " asthma " like coughs. Seems like his nose ran for 10 years. He had a cough for 42 days and was admitted. He was also admitted when he was on IVIG and there was a shortage. He went 5 weeks and got sick. He is almost 13 and only been in the hospital twice. His neutrophils have always been fine. The only thing that was off with him is total IgG and Ig1 and Ig2. We have been really lucky. His IgG dropped to 201 before we decided to treat him. I don't know about the shots, sorry. Someone on here will though! @...: momof2withga2@...: Thu, 11 Dec 2008 16:17:20 -0800Subject: RE: Subclass 2 deficiency Thanks for the great explanation. I also found some of the things you said online. Would this possibly account for my sons very high fever with his baby shots last week? He has now had 10 ear infections. Currently had one plus a sinus infection. How do you know whether to blame neutrophils or Igg levels for infections?Best Regards,Krystena sAmbassador, United Mitochondrial Disease Foundationhttp://www.umdf.org/site/c.dnJEKLNqFoG/b.3041929/Region 4 " Genetics Care Coordation " phone:859-749-7366fax:859-499-3477From: laura smith <iamlaurasmith@...>Subject: RE: Subclass 2 deficiencyTo: " healyh " < >Date: Thursday, December 11, 2008, 3:53 PMHello,My son has IgG Subclass def. He is Ig1 and Ig2 deficient. (Leave it to us to have the most common and the most rare forms!) As I understand it, Ig2 is the most common. Here is what I found on the internet. Because IgG2 is important in response to polysaccharides, encapsulated bacteria (eg, H influenzae type b, S pneumoniae) are common causes of infection in these patients. Antibodies reactive with bacterial cell wall antigens are thought to be predominantly of the IgG2 isotype. Patients may be unable to produce specific antibodies after immunization with purified polysaccharide antigens (eg, pneumococcal vaccine polyvalent [Pneumovax]) . More than 10% of these patients also present with dermal or visceral vasculitis.This makes sense because my son had problems with colds, brochitis, flus, more lung and sinus related issues. Several drs thought he had asthma. He also does not make responses to polysccharide vaccines. Hope this helps some. groups (DOT) comFrom: momof2withga2@ Date: Thu, 11 Dec 2008 09:53:01 -0800Subject: Subclass 2 deficiencyHi all, We just found out that our little one has a subclass 2 deficiency. We haven't yet talked to the immunologist as these results were passed on by the geneticist.Does anyone know what this means?Best Regards,Krystena sAmbassador, United Mitochondrial Disease Foundationhttp: //www.umdf. org/site/ c.dnJEKLNqFoG/ b.3041929/ Region 4 " Genetics Care Coordation " phone: 859-749-7366fax: 859-499-3477[ Non-text portions of this message have been removed] ____________ _________ _________ _________ _________ _________ _Send e-mail faster without improving your typing skills.http://windowslive. com/Explore/ hotmail?ocid= TXT_TAGLM_ WL_hotmail_ acq_speed_ 122008 Quote Link to comment Share on other sites More sharing options...
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