Re: how long before its too long out of remision?

[Guest guest]

Gosh I never reached full remission on Gleevec and there was never any talk

of a bone marrow transplant. I was on it for four years. I did better on

Sprycel, and will soon find out how I'm doing on Tasigna. By remission do

you mean PCRU?

On Sat, May 29, 2010 at 4:50 PM, lisadutton1981 <minx101@...> wrote:

>

>

> Hi

>

> I dont post on here much but read the emails that come though. My husband

> was dx with CML 15 months ago and is on Glivec 400 a day. His doing well but

> this weeks appointment had no remission yet, so discussion about BMT

> started. His last load of tests in Feb showed reduction in BCR ABL results

> but his due another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec? His

> specialist seemed to think it may be a option later as my husband is only 33

> and we have 2 small children.

>

> We would rather try other options before consdiering BMT but im not sure.

> Any help would be great.

>

>

>

[Guest guest]

Hi, I have had CML for 15 years, and never reached PCRU until a few months

ago.  I have been fortunate enough to be in 6 trials, the first being Gleevec,

which after `1 1/2 years no longer worked.  Sprycel was the first drug to put

me in CCR, which, if you achieve this, even Dr. Druker says it is good enough. I

would surely not jump into a transplant without exhausting all possibilities. 

Lottie, on our list, only just recently reached CCR, and she has had CML almost

as long as me. Some of us just take longer than others, be patient, and if your

doctor insists on transplant, get another opinion, like from Dr. Druker or Dr.

Talpaz.  Take care, Bobby

Is there a time limit that you have to reach remission by if on glivec? His

specialist seemed to think it may be a option later as my husband is only 33 and

we have 2 small children.

We would rather try other options before consdiering BMT but im not sure.

Any help would be great.

[Guest guest]

Hi :  What do you mean by remission?  You said your husband is on Gleevec

now for 15 months.  Has he achieved a cytogenetic remission, meaning has his

counts come down to normal.  You did not post too much information, but I can

tell you that if Gleevec is not working that there are other treatments

available.  There is Tasigna and Sprycel.  There are also new drugs in trial.

     The first thing I ask is if your husband is seeing a CML Specialist. 

Someone who really knows all about CML.  So many people lately have been told

to go for a BMT right away because their drug is not working.

     We have some very experienced people on here, and they will advise you

better than myself as to what your husband should do. I am not good at

explaining things in detail.

     Do not panic until your husband seeks other opinions.  There is so

much available out there since Gleevec was introduced as the first line of

treatment.

     Its a holiday weekend , and there are not too many people on here

sometimes over the weekend.  You will get plenty of responses during the

week.  Once your husband gets the right treatment and right doctor he will do

okay.

    Keep checking the message board for a answer to your questions.

From: lisadutton1981 <minx101@...>

Subject: [ ] how long before its too long out of remision?

Date: Saturday, May 29, 2010, 7:50 PM

 

Hi

I dont post on here much but read the emails that come though. My husband was dx

with CML 15 months ago and is on Glivec 400 a day. His doing well but this weeks

appointment had no remission yet, so discussion about BMT started. His last load

of tests in Feb showed reduction in BCR ABL results but his due another BMB

soon.

Is there a time limit that you have to reach remission by if on glivec? His

specialist seemed to think it may be a option later as my husband is only 33 and

we have 2 small children.

We would rather try other options before consdiering BMT but im not sure.

Any help would be great.

[Guest guest]

I have been PCRU since I as diagnosised 7 yrs. ago. I am fortunate that Gleevec

worked well for 5 yrs. While a lot of doctors are still pushing for younger

patients have a BMT, most of the medicines available to us have made that option

one of the last options to consider. As long as the CML tests keep indicating a

reduction or that the levels are being maintained then I believe the medicine

should be continued. Since there are now several different medicines and trails

that option is much better than the one option I had when I was diagnosed. Good

luck on the next set of tests.

H.

dxd 2/2003

400mg Gleevec 3/2003

Undetectable 11/03

RT-PCR negative 11/04

QT-PCR .003 11/05

RBC 8.

Gleevec Vacation 11/06-6/07

Iron infusion 11/06

Transfusions 12/06-5/07

QT-PCR .7

Gleevec 1/08 -5/08

Procrit 8/08-11/08

Gleevec Vacation 7/08-Pressent

QT-PCR .03 4/09

QT-PCR .015 6/09

QT-PCR .021 9/09

QT-PCR .028 1/10

QT-PCR .01+ 4/10

>

> Hi

>

> I dont post on here much but read the emails that come though. My husband was

dx with CML 15 months ago and is on Glivec 400 a day. His doing well but this

weeks appointment had no remission yet, so discussion about BMT started. His

last load of tests in Feb showed reduction in BCR ABL results but his due

another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec? His

specialist seemed to think it may be a option later as my husband is only 33 and

we have 2 small children.

>

> We would rather try other options before consdiering BMT but im not sure.

> Any help would be great.

>

[Guest guest]

I have never posted, but have read e-mails and posts since being diagnosed with

CML about a year and a half ago. I am a 35 year old lucky husband and a father

of a two-and-a-half year old beautiful little girl.

I was on 400 mg of Gleevec until my PCR results at 1 year showed that I was

still had not achieved a Complete Cytogenetic Response (CCyR, 2 log reduction).

My test showed the same ratio as the test 3 months prior. My doctor sent my

blood in for Gleevec Blood Level Testing and found that I was not receiving

nearly enough medication. My dose was increased to 600 mg, and in early May, I

finally achieved CCyR. Another Blood Level Test showed that my dose is now

right on target. I have been fortunate to have no side effects at either dose.

This is only my experience, and I am certainly no expert, but I can relate a

little to your husband in terms of age, situation, and probable anxiety of being

at 15 months and still not where you need/want to be in CML response. I've

gathered that achieving CCyR by 18 months is kind of the " goal " and so far a

great indicator of long term success. I was worried about not achieving this,

but my doc assured me that this is true only when you are receiving the proper

dosage, so the clock started over for me when I started taking 600 mg.

Now if my numbers still were not decreasing with the proper dosage, the next

step was a mutation test and probably a switch to Tasigna. So far, we have

never even fancied the idea of a BMT.

If your husband's doc hasn't already mentioned it, perhaps you could ask about

the Blood Level Testing for Gleevec and see if it is something that could shed

some light on his response.

Wishing you well...

PJ in NC

PS - Zavie, do I get a number now? (If so, please make it a lucky one!!!)

>

> Hi

>

> I dont post on here much but read the emails that come though. My husband was

dx with CML 15 months ago and is on Glivec 400 a day. His doing well but this

weeks appointment had no remission yet, so discussion about BMT started. His

last load of tests in Feb showed reduction in BCR ABL results but his due

another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec? His

specialist seemed to think it may be a option later as my husband is only 33 and

we have 2 small children.

>

> We would rather try other options before consdiering BMT but im not sure.

> Any help would be great.

>

[Guest guest]

My husband was dx with CML 15 months ago and is on Glivec 400 a day. His doing

well but this weeks appointment had no remission yet, so discussion about BMT

started. His last load of tests in Feb showed reduction in BCR ABL results but

his due another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec?

_________________________________

Hi,

Where do you live? the spelling Glivec is not used in the US?

and as others ask, what do you mean by not reaching 'remission' yet in 15

months?

Rarely does any patient in the days of these new drugs go on to have a

BMT..because there are so many drug options. It does not sound like his doctor

knows the present protocols for treating CML. If he is responding to 400mg

Glivec (ph+ cells are getting less, on various tests, ie bmb....FISH.......PCR)

then it might just stay the course with Glivec. Or he might be put on another

drug....the 2nd generation drugs are all considered to be stronger/more potent.

Give the list more information about the response he has had so far, and we can

tell you more.

C.

[Guest guest]

O!!! YIPPEEE!!!

Number 1323 in the Zero Club

Zavie

Zavie (age 72)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

3.7 log reduction Jan/09

3.8 log reduction May/09

3.8 log reduction Aug/09

4.0 log reduction Dec/09

4.4 log reduction Apr/10

e-mail: zmiller@...

_____

From: [mailto: ] On Behalf Of

pjfroncz

Sent: May 30, 2010 2:20 PM

Subject: [ ] Re: how long before its too long out of remision?

I have never posted, but have read e-mails and posts since being diagnosed

with CML about a year and a half ago. I am a 35 year old lucky husband and a

father of a two-and-a-half year old beautiful little girl.

I was on 400 mg of Gleevec until my PCR results at 1 year showed that I was

still had not achieved a Complete Cytogenetic Response (CCyR, 2 log

reduction). My test showed the same ratio as the test 3 months prior. My

doctor sent my blood in for Gleevec Blood Level Testing and found that I was

not receiving nearly enough medication. My dose was increased to 600 mg, and

in early May, I finally achieved CCyR. Another Blood Level Test showed that

my dose is now right on target. I have been fortunate to have no side

effects at either dose.

This is only my experience, and I am certainly no expert, but I can relate a

little to your husband in terms of age, situation, and probable anxiety of

being at 15 months and still not where you need/want to be in CML response.

I've gathered that achieving CCyR by 18 months is kind of the " goal " and so

far a great indicator of long term success. I was worried about not

achieving this, but my doc assured me that this is true only when you are

receiving the proper dosage, so the clock started over for me when I started

taking 600 mg.

Now if my numbers still were not decreasing with the proper dosage, the next

step was a mutation test and probably a switch to Tasigna. So far, we have

never even fancied the idea of a BMT.

If your husband's doc hasn't already mentioned it, perhaps you could ask

about the Blood Level Testing for Gleevec and see if it is something that

could shed some light on his response.

Wishing you well...

PJ in NC

PS - Zavie, do I get a number now? (If so, please make it a lucky one!!!)

>

> Hi

>

> I dont post on here much but read the emails that come though. My husband

was dx with CML 15 months ago and is on Glivec 400 a day. His doing well but

this weeks appointment had no remission yet, so discussion about BMT

started. His last load of tests in Feb showed reduction in BCR ABL results

but his due another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec?

His specialist seemed to think it may be a option later as my husband is

only 33 and we have 2 small children.

>

> We would rather try other options before consdiering BMT but im not sure.

> Any help would be great.

>

[Guest guest]

Thanks for all the replys.

Sorry I should have said more on first post.

And yes I spelt it wrong too, it was late

Darren was dx in March 2009 after a blood test as he has been unwell for a long

time. He was pulled straight into hospital with wbc of 414.

Started on hydreroxia (sp??) and then Gleevec at 400.

They lost his baseline results from first week, but second BCR ABL showed 90%,

second lost 6 months later 36% and last lot at a year was 9% so all going down.

When I say remission I mean that the FISH and BCR ABL show less than 0.1% (well

thats the way we have been told)

Does that all make sense?

Also his doc has said he doesnt require any BMB at all now, as the bloods are a

good sign. I know of one man who had good blood reductions but BMB showed little

impact. Do you lot get BMB often?

I do sometimes feel that his doc is kinda just waving us off because its a " good

cancer " (in their words) and isnt a problem for them.

Thanks to all

[Guest guest]

LISA, MY SON PAT WAS DIAGNOSED IN AUGUST OF LAST YEAR AND HE HAS HAD 3 BMB/BMA.

HE IS GOING FOR HIS 4TH. IN AUGUST.HE IS STILL NOT CCR OR PCR. OUR HEMO/ONCO

SAID IT IS NOT UNUSUAL FOR THIS AS EVERYONE IS DIFFERENT AND IF HE DOESEN'T

REACH THESE THERE ARE ALTERNATIVE MEDS TO USE. WITH IT IS A WAITING GAME.

YOUR HUSBAND NEEDS A NEW DOC. IF HE THINKS THIS DISEASE IS A " GOOD CANCER " THERE

IS NO SUCH ANIMAL! JUST KEEP ON PLUGGING AND GET A NEW DOC. OUR PRAYERS ARE WITH

YOU.                                      \

                           

                                        \

                      PEGGY BIEBER,MOTHER OF PAT, 38

DIAGNOSED 8/09

63

From: lisadutton1981 <minx101@...>

Subject: Re: [ ] how long before its too long out of remision?

Date: Monday, May 31, 2010, 9:50 AM

 

Thanks for all the replys.

Sorry I should have said more on first post.

And yes I spelt it wrong too, it was late

Darren was dx in March 2009 after a blood test as he has been unwell for a long

time. He was pulled straight into hospital with wbc of 414.

Started on hydreroxia (sp??) and then Gleevec at 400.

They lost his baseline results from first week, but second BCR ABL showed 90%,

second lost 6 months later 36% and last lot at a year was 9% so all going down.

When I say remission I mean that the FISH and BCR ABL show less than 0.1% (well

thats the way we have been told)

Does that all make sense?

Also his doc has said he doesnt require any BMB at all now, as the bloods are a

good sign. I know of one man who had good blood reductions but BMB showed little

impact. Do you lot get BMB often?

I do sometimes feel that his doc is kinda just waving us off because its a " good

cancer " (in their words) and isnt a problem for them.

Thanks to all

[Guest guest]

Hi , you did not spell it wrong, there are just two different ways to say it

and spell it, in other countries it is Glivec, in the U.S.  it is Gleevec, same

thing.

I  think from his FISH it sounds like he is doing real well and very fast.  It

took me 4 years, from the time I was on Gleevec in 2000, and 3 trials later to

reach cytogenic remission.  I don't know of doctors that do a BMA every 3

months unless they are in a clinical trial for a drug, especially when they are

responding so well.  If I am wrong, I am sure someone will let us know.  

Where do you live, maybe someone here can suggest a doctor with  more

experience, or perhaps you could suggest to your doctor, while you are with him

to listen that he consult Dr. Druker in Oregon, or Dr. Talpaz in Michigan. 

They are the two

best doctors on CML, in my opinion in the whole world, and either one would be

glad to consult with your doctor.

About " good cancer " ....when I was first diagnosed in May of 1995, I went to a

support group for CML.  The speaker said this:  when people are first

diagnosed with CML, they are in denial first, then when they accept it they get

angry and wonder " why me " , and finally, they are thankful they have a " good

cancer " , meaning as opposed to bone cancer, or

uterine cancer or brain cancer, we should consider ourselves very lucky.  I

have a son in law with Parkinson's, and when he was diagnosed I told him if he

was going to get something at age 50, why couldn't it have been what I've got, a

good cancer!!  I would not want to be in his shoes for anything, and I thank

God every day for the truly good life I have led since I first took Gleevec,

even if it didn't work for me.

Good luck to you and your husband, and remember if

gleevec ends up not working for him, Sprycel and Tasigna are out there, plus

the drug Ariad that I am in trial now for is showing great results.  Put the

word transplant out of your mind until you have exhausted all the other great

choices out there, and lead a good and happy life.  When us old timers were

diagnosed, before the event of Gleevec, the treatment was Interferon, and

believe me, when most of us look back on that shot every day and the terrible

side effects, we shudder!!! But then, we were only given about 5 years to live

- today there is no limit, thanks to Gleevec.

How many BMA/BNB 's do we usually get? Lottie and I and quite a few others

that have been in trials for about 10 years have had 45, maybe 50, but once

someone has reached cytogenic remission I think maybe only one a year? Not

sure, because I am always in a trial, I have stubborn cells that to not respond

very well the the drugs as well or as fast as others.

I seems your husband is responding well, get on with your life and don't even

worry about CML, eat, drink and be merry!!!! Bobby

a ( Bobby ) Doyle, dob 12/17/29

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.01

11/2009 PCR 0.034

02/2010 PCRU

#840 Zavie's Zero Club

--- On

Mon, 5/31/10, lisadutton1981 <minx101@...> wrote:

From: lisadutton1981 <minx101@...>

Subject: Re: [ ] how long before its too long out of remision?

Date: Monday, May 31, 2010, 5:50 AM

 

Thanks for all the replys.

Sorry I should have said more on first post.

And yes I spelt it wrong too, it was late

Darren was dx in March 2009 after a blood test as he has been unwell for a long

time. He was pulled straight into hospital with wbc of 414.

Started on hydreroxia (sp??) and then Gleevec at 400.

They lost his baseline results from first week, but second BCR ABL showed 90%,

second lost 6 months later 36% and last lot at a year was 9% so all going down.

When I say remission I mean that the FISH and BCR ABL show less than 0.1% (well

thats the way we have been told)

Does that all make sense?

Also his doc has said he doesnt require any BMB at all now, as the bloods are a

good sign. I know of one man who had good blood reductions but BMB showed little

impact. Do you lot get BMB often?

I do sometimes feel that his doc is kinda just waving us off because its a " good

cancer " (in their words) and isnt a problem for them.

Thanks to all

[Guest guest]

Hi Bobby,

Well said. I am so thankful that you and Lottie and some of the other " Old

Timers " are members of this group. You all have a way of putting things in

perspective. Lots of wisdom -- and no I'm not saying you are old - ha...

Have a great Memorial Day!

Warmest,

Don

>

> From: lisadutton1981 <minx101@...>

> Subject: Re: [ ] how long before its too long out of remision?

>

> Date: Monday, May 31, 2010, 5:50 AM

>

>

>

>

>

>

>

>  

>

>

>

>

>

>

>

>

>

>

>

> Thanks for all the replys.

>

> Sorry I should have said more on first post.

>

> And yes I spelt it wrong too, it was late

>

>

>

> Darren was dx in March 2009 after a blood test as he has been unwell for a

long time. He was pulled straight into hospital with wbc of 414.

>

> Started on hydreroxia (sp??) and then Gleevec at 400.

>

> They lost his baseline results from first week, but second BCR ABL showed 90%,

second lost 6 months later 36% and last lot at a year was 9% so all going down.

>

> When I say remission I mean that the FISH and BCR ABL show less than 0.1%

(well thats the way we have been told)

>

> Does that all make sense?

>

> Also his doc has said he doesnt require any BMB at all now, as the bloods are

a good sign. I know of one man who had good blood reductions but BMB showed

little impact. Do you lot get BMB often?

>

> I do sometimes feel that his doc is kinda just waving us off because its a

" good cancer " (in their words) and isnt a problem for them.

>

>

>

> Thanks to all

>

[Guest guest]

> Hi,

> Where do you live? the spelling Glivec is not used in the US?

> and as others ask, what do you mean by not reaching 'remission' yet in 15

months?

_____________________

Hi, I was not criticizing your spellling...I figured you were from Canada or

Europe, where the drug is spelled that way.....and sometimes we assume people

are from the US and recommend doctors that they do not have access to. I should

have written it differently.

There is a story about the 2 spellings.....the drug makers/FDA thought that

those of us in the US would not know how to pronounce the drug correctly like it

is spelled everywhere else (Glivec)....so they spelled it phonetically for us!

About the good cancer.....actually I think it was originally called the 'good

leukemia'. Before Gleevec, CML was a pretty automatic death sentence in 5-7

years unless you had a successful transplant (and some people are too old and

some don't have a donor). This all changed with Gleevec....it went from

basically fatal to a chronic treatable disease, and most people will have a

normal life span. So, almost overnight, it did become the 'good leukemia'....and

is also better than most cancers.

Your husband is making good progress....and no one should be talking about a BMT

for him. Whoever said that is not current with cml treatment. Just enjoy life as

Bobby says.

C.

[Guest guest]

Hi : First let me say that its a good thing for you to post on here. We

are all here to help. From what you are saying, I think you need to get a new

Oncologist. If your husband is only in a cytogenetic remission, he still should

be monitored every 6 months with A BMB. Also are they doing a PCR Blood Test?

Just make sure you are seeing an experienced doctor who works with CML, and

knows what he is doing.

Do your husband and yourself a favor and go see another doctor for a second

opinion. I went for numerous opinions to be sure I was on the right track. You

might be near one of the big hospitals who has the top doctors in the field of

CML. I was diagnosed in 1998, and even though I am doing good. I still keep up

on what is going on in the study and research and trials that are going on for

CML.

Take Care No Cancer is A Good Cancer, but what they say is that if you have to

get Leukemia that the CML is a good one compared to others, because it can be

treated better.

A

>

>

> Thanks for all the replys.

> Sorry I should have said more on first post.

> And yes I spelt it wrong too, it was late

>

> Darren was dx in March 2009 after a blood test as he has been unwell for a

long time. He was pulled straight into hospital with wbc of 414.

> Started on hydreroxia (sp??) and then Gleevec at 400.

> They lost his baseline results from first week, but second BCR ABL showed 90%,

second lost 6 months later 36% and last lot at a year was 9% so all going down.

> When I say remission I mean that the FISH and BCR ABL show less than 0.1%

(well thats the way we have been told)

> Does that all make sense?

> Also his doc has said he doesnt require any BMB at all now, as the bloods are

a good sign. I know of one man who had good blood reductions but BMB showed

little impact. Do you lot get BMB often?

> I do sometimes feel that his doc is kinda just waving us off because its a

" good cancer " (in their words) and isnt a problem for them.

>

> Thanks to all

>

[Guest guest]

Hi ,

I think it is premature to talk about a BMT at this point... that's a rough

process and your husband should be in otherwise very good health... even

then there are no guarantees. I agree with those who say that as long as

there is a continuing reduction in the BRC/ABL counts you should stay the

course or, maybe, try one of the other drugs. I know that there are medical

considerations that we may not all be aware of, but a BMT is a BFD (pardon

my language) and not to be taken lightly.

Troxel

dx 2/2003

Gleevec 3/2003

On 5/29/10, lisadutton1981 <minx101@...> wrote:

>

>

>

> Hi

>

> I dont post on here much but read the emails that come though. My husband

> was dx with CML 15 months ago and is on Glivec 400 a day. His doing well but

> this weeks appointment had no remission yet, so discussion about BMT

> started. His last load of tests in Feb showed reduction in BCR ABL results

> but his due another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec? His

> specialist seemed to think it may be a option later as my husband is only 33

> and we have 2 small children.

>

> We would rather try other options before consdiering BMT but im not sure.

> Any help would be great.

>

>

>

[Guest guest]

Hi ,

I may be out of line here, but I am on 400 Gleevec a day and told that if my

fish starts to show more they would increase it. I go to Strong Memorial Hosp in

Rochester, NY and had a BMT 15 years ago and was told if I did not do it, I

would only live 3 years. So I did it. But now for the CML, I was told at my bi

annual check up earlier today, that they would not do BMT on people any more for

the CML unless it is a urgent issue, because they can really control it well

with the Gleevec and then with other drugs if that does not continue to work. (

She told me that people can live over 20 years on Gleevec) I was told that if

there was more activity, they would do high doses of the Gleevec. They told me

the 400 is the base low. So from what I was told, there is a lot more to add to

it if needed.

I did an autologist BTM and donated to myself. Therefore after my transplant I

gave my self the CML again. But I was on an experimental drug for four years.( I

am only 1 of 2 survivors of the trial to still be alive) If I knew then what I

know know about Gleevec (which was not invented then!) I would not have done the

BMT.

The Leukemia Society has great information on all studies being done and all

trials being conducted all over the country. That is how I found Strong. Doing

research is a great source of taking control for the one with the Leukemia. They

also helped with financial assistance for transportation and cost for lodging

when I was first going through the testing and the follow up visits.

Just a thought. I was 34 when I started the journey. I had five kids. So I know

what he must be feeling. But a strong and loving family will definitely make his

journey much easier to understand what he must do and when he should do it.

Best to all of you

Walt

________________________________

From: Troxel <richard.troxel@...>

Sent: Tue, June 1, 2010 10:41:03 PM

Subject: Re: [ ] how long before its too long out of remision?

Hi ,

I think it is premature to talk about a BMT at this point... that's a rough

process and your husband should be in otherwise very good health... even

then there are no guarantees. I agree with those who say that as long as

there is a continuing reduction in the BRC/ABL counts you should stay the

course or, maybe, try one of the other drugs. I know that there are medical

considerations that we may not all be aware of, but a BMT is a BFD (pardon

my language) and not to be taken lightly.

Troxel

dx 2/2003

Gleevec 3/2003

On 5/29/10, lisadutton1981 <minx101@...> wrote:

>

>

>

> Hi

>

> I dont post on here much but read the emails that come though. My husband

> was dx with CML 15 months ago and is on Glivec 400 a day. His doing well but

> this weeks appointment had no remission yet, so discussion about BMT

> started. His last load of tests in Feb showed reduction in BCR ABL results

> but his due another BMB soon.

>

> Is there a time limit that you have to reach remission by if on glivec? His

> specialist seemed to think it may be a option later as my husband is only 33

> and we have 2 small children.

>

> We would rather try other options before consdiering BMT but im not sure.

> Any help would be great.

>

>

>