RE: Subclass 3 deficiency

[Guest guest]

Hi all,

I was wondering if anyone here has any information on a subclass 3 deficiency.

My son has a total IgG deficiency and he's been on IVIG since April 2008,but his

latest labs show an subclass 3 deficiency. His IgG level has risen to about 700

from 500 but his subclass 3 is low @ 17 ref. range (26-113). His subclasses 1

and 2 are also very borderline but not low? Thanks for any info. and take good

care.

@...: iamlaurasmith@...: Fri, 12 Dec 2008

00:27:16 +0000Subject: RE: Subclass 2 deficiency

's illnesses were not major. Ear infections, cold, " asthma " like coughs.

Seems like his nose ran for 10 years. He had a cough for 42 days and was

admitted. He was also admitted when he was on IVIG and there was a shortage. He

went 5 weeks and got sick. He is almost 13 and only been in the hospital twice.

His neutrophils have always been fine. The only thing that was off with him is

total IgG and Ig1 and Ig2. We have been really lucky. His IgG dropped to 201

before we decided to treat him. I don't know about the shots, sorry. Someone on

here will though! @...:

momof2withga2@...: Thu, 11 Dec 2008 16:17:20 -0800Subject: RE:

Subclass 2 deficiencyThanks for the great explanation. I also found

some of the things you said online. Would this possibly account for my sons very

high fever with his baby shots last week? He has now had 10 ear infections.

Currently had one plus a sinus infection. How do you know whether to blame

neutrophils or Igg levels for infections?Best Regards,Krystena

sAmbassador, United Mitochondrial Disease

Foundationhttp://www.umdf.org/site/c.dnJEKLNqFoG/b.3041929/Region 4 " Genetics

Care Coordation " phone:859-749-7366fax:859-499-3477From: laura smith

<iamlaurasmith@...>Subject: RE: Subclass 2 deficiencyTo:

" healyh " < >Date: Thursday, December 11, 2008, 3:53

PMHello,My son has IgG Subclass def. He is Ig1 and Ig2 deficient. (Leave it to

us to have the most common and the most rare forms!) As I understand it, Ig2 is

the most common. Here is what I found on the internet. Because IgG2 is important

in response to polysaccharides, encapsulated bacteria (eg, H influenzae type b,

S pneumoniae) are common causes of infection in these patients. Antibodies

reactive with bacterial cell wall antigens are thought to be predominantly of

the IgG2 isotype. Patients may be unable to produce specific antibodies after

immunization with purified polysaccharide antigens (eg, pneumococcal vaccine

polyvalent [Pneumovax]) . More than 10% of these patients also present with

dermal or visceral vasculitis.This makes sense because my son had problems with

colds, brochitis, flus, more lung and sinus related issues. Several drs thought

he had asthma. He also does not make responses to polysccharide vaccines. Hope

this helps some. groups (DOT) comFrom: momof2withga2@

Date: Thu, 11 Dec 2008 09:53:01 -0800Subject: Subclass 2

deficiencyHi all, We just found out that our little one has a subclass 2

deficiency. We haven't yet talked to the immunologist as these results were

passed on by the geneticist.Does anyone know what this means?Best

Regards,Krystena sAmbassador, United Mitochondrial Disease

Foundationhttp: //www.umdf. org/site/ c.dnJEKLNqFoG/ b.3041929/ Region 4

" Genetics Care Coordation " phone: 859-749-7366fax: 859-499-3477[ Non-text

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