Re: PPI's (Proton Pump Inhibitors)

[Guest guest]

Hi tracey I am taking Nexium once a day and I am not sure if it does have any

effect on my PCRU. I lost my PCRU when they reduce my Gleevec dose to 200mg

after taking 400mg my numbers are getting better slowly in spite of Nexium,

T

Sent from my Verizon Wireless BlackBerry

[ ] PPI's (Proton Pump Inhibitors)

Hi Everyone,

I'm curious to know how many of you are taking a Proton Pump Inhibitor such as

Losec, Prilosec, Prevacid, Nexium, or Protonix and if it's had any effect on

your PCR?

Tracey

[Guest guest]

Hi Tracey, I have been on Prevacid about one month, so don't really know.  I

was on Imeprasole  and it was fine with the PCR, but had dire side effects. 

Dr. Talpaz has ok'd  Prevacid, so I doubt it will bother anything.  Bobby

a ( Bobby ) Doyle, dob 12/17/29

DX 5/1995

Interferon 9 weeks/Hydroxyurea 5 years

02/2000 to 06/2002 Gleevec trial, OHSU

06/2002 Gleevec/Trisenox Trial, OHSU

06/2003 Gleevec/Zarnestra Trial, OHSU

04/2004 Sprycel Trial, MDACC, CCR in 10 months

04/2008 XL228 Trial, U of Mich.

01/2009 PCR 5.69

04/2009 Ariad Trial AP24534

09/2009 PCR 0.01

11/2009 PCR 0.034

02/2010 PCRU

#840 Zavie's Zero Club

From: mtadros9@... <mtadros9@...>

Subject: Re: [ ] PPI's (Proton Pump Inhibitors)

" CML Group " < >

Date: Tuesday, June 1, 2010, 9:57 AM

 

Hi tracey I am taking Nexium once a day and I am not sure if it does have

any effect on my PCRU. I lost my PCRU when they reduce my Gleevec dose to 200mg

after taking 400mg my numbers are getting better slowly in spite of Nexium,

T

Sent from my Verizon Wireless BlackBerry

[ ] PPI's (Proton Pump Inhibitors)

Hi Everyone,

I'm curious to know how many of you are taking a Proton Pump Inhibitor such as

Losec, Prilosec, Prevacid, Nexium, or Protonix and if it's had any effect on

your PCR?

Tracey

[Guest guest]

Hi ,

I take Pantoprazole (Somac in OZ) ~ Protonix after I was dx with a gastric

ulcer last July. I have since reduced my Tasigna from 800mg a day to 600mg

in February, as Tasigna has caused a nasty flare up of my Crohn's Disease

and still remain PCRU since Dec 08.

Regards,

From: [mailto: ] On Behalf Of

traceyincanada

Sent: Tuesday, 1 June 2010 11:18 PM

Subject: [ ] PPI's (Proton Pump Inhibitors)

Hi Everyone,

I'm curious to know how many of you are taking a Proton Pump Inhibitor such

as Losec, Prilosec, Prevacid, Nexium, or Protonix and if it's had any effect

on your PCR?

Tracey

E-mail message checked by Internet Security (7.0.0.514)

Database version: 6.15120

http://www.pctools.com/internet-security/

<http://www.pctools.com/en/internet-security/>

E-mail message checked by Internet Security (7.0.0.514)

Database version: 6.15120

http://www.pctools.com/en/internet-security/

[Guest guest]

:

Is there an issue with PPI's?

Sent from my iPhone

On Jun 1, 2010, at 9:18 AM, " traceyincanada "

<traceyincanada@...> wrote:

> Hi Everyone,

>

> I'm curious to know how many of you are taking a Proton Pump

> Inhibitor such as Losec, Prilosec, Prevacid, Nexium, or Protonix and

> if it's had any effect on your PCR?

>

> Tracey

>

>

[Guest guest]

That's what I'm trying to determine Matt. There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach but so far I haven't found any

evidence to suggest that there is any interaction.

Tracey

>

> > Hi Everyone,

> >

> > I'm curious to know how many of you are taking a Proton Pump

> > Inhibitor such as Losec, Prilosec, Prevacid, Nexium, or Protonix and

> > if it's had any effect on your PCR?

> >

> > Tracey

> >

> >

>

>

>

[Guest guest]

Was told not to take PPIs.

Sent from my Verizon Wireless BlackBerry

Re: [ ] PPI's (Proton Pump Inhibitors)

That's what I'm trying to determine Matt. There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI

since it reduces the acid content of the stomach but so far I haven't found any

evidence to suggest that there is any interaction.

Tracey

>

> > Hi Everyone,

> >

> > I'm curious to know how many of you are taking a Proton Pump

> > Inhibitor such as Losec, Prilosec, Prevacid, Nexium, or Protonix and

> > if it's had any effect on your PCR?

> >

> > Tracey

> >

> >

>

>

>

[Guest guest]

I have taken Nexium since day one and I am stillPCRU. Lynn F.

Re: [ ] PPI's (Proton Pump Inhibitors)

That's what I'm trying to determine Matt. There was some speculation a while

ago that Gleevec must be exposed to an acidic environment in order to be

metabolized. This of course would be a problem if someone was taking a PPI since

it reduces the acid content of the stomach but so far I haven't found any

evidence to suggest that there is any interaction.

Tracey

>

> > Hi Everyone,

> >

> > I'm curious to know how many of you are taking a Proton Pump

> > Inhibitor such as Losec, Prilosec, Prevacid, Nexium, or Protonix and

> > if it's had any effect on your PCR?

> >

> > Tracey

> >

> >

>

>

>

[Guest guest]

Hi Tracey: I developed GERD after starting my Gleevec in 2000, and I have been

on Nexium now for years, even before I became PCRU. In my case it has not done

anything to my PCR results. I have had no problems.

A.

>

> Hi Everyone,

>

> I'm curious to know how many of you are taking a Proton Pump Inhibitor such as

Losec, Prilosec, Prevacid, Nexium, or Protonix and if it's had any effect on

your PCR?

>

> Tracey

>

[Guest guest]

Ah, I see, it may explain

some people's poor absorbtion

and performance. Very

insightful.

Sent from my iPhone

On Jun 1, 2010, at 12:26 PM, " traceyincanada "

<traceyincanada@...> wrote:

> That's what I'm trying to determine Matt. There was some speculation

> a while ago that Gleevec must be exposed to an acidic environment in

> order to be metabolized. This of course would be a problem if

> someone was taking a PPI since it reduces the acid content of the

> stomach but so far I haven't found any evidence to suggest that

> there is any interaction.

>

> Tracey

>

>

> >

> > > Hi Everyone,

> > >

> > > I'm curious to know how many of you are taking a Proton Pump

> > > Inhibitor such as Losec, Prilosec, Prevacid, Nexium, or Protonix

> and

> > > if it's had any effect on your PCR?

> > >

> > > Tracey

> > >

> > >

> >

> >

> >

[Guest guest]

I was on Prilosec for years before I was diagnosed with CML in 2000. I have

been on Nexium for about six or seven years. I remain PCR-U (since September,

2002).

B from California

(must change e-mail address; I see this is an old one. New is

nancybelcher@...)

[Guest guest]

Yes, I'm taking PPI due to horrible reflux. Don't know if it has affected my

PCR. Is there some link to that?

Vicki

>

> Hi Everyone,

>

> I'm curious to know how many of you are taking a Proton Pump Inhibitor such as

Losec, Prilosec, Prevacid, Nexium, or Protonix and if it's had any effect on

your PCR?

>

> Tracey

>