Guest guest Posted September 12, 2010 Report Share Posted September 12, 2010 This is an older interview by Schorr, a CLL survivor himself, given by Dr. Talpaz and Dr. Giles. There is a webcast that you can download rather than read the interview. I read it and noted that AMN & BMS were in trials, but they referred to other therapies that targeted mutations were also in the pipes. I found it interesting and anyway, maybe some of you will, too, especially newcomers or those worried about what happens if Gleevec doesn't work for them, there are other drugs forthcoming. I have and perhaps some of you may have already read some of his other articles. ( Schorr of Seattle is a medical journalist who was diagnosed with chronic lymphocytic leukemia in 1996. By participating in a clinical trial he has enjoyed a deep and lasting remission which has enabled him to be a pioneer in providing authoritative medical information online for other people facing serious illness. As a passionate patient-advocate, and with support from many of America's leading medical centers, has hosted and helped produce several thousand webcasts and videos for patients who have cancer or a wide range of chronic and acute medical concerns.) http://www.everydayhealth.com/cancer/webcasts/new-discoveries-in-cml-treatment-t\ ranscript-2.aspx _____________________________________ PEOPLE WHO STOP DRUGS BECAUSE OF ECONOMIC REASONS WEDNESDAY, Aug. 4 (HealthDay News) -- In 2009 and 2010, as the economic collapse shuddered across the globe, oncologists in California noticed a troubling trend: Three patients who had had serious tumors under control for as long as eight years reappeared in the clinic with massive cancer regrowth which, in one case, required emergency surgery. http://www.everydayhealth.com/publicsite/news/view.aspx?id=641844 ____________________________________ Are FDA Regulators Preventing the Terminally Ill From Accessing Promising New Cancer Drugs? " Sen. Sam Brownback (R-Kans.) and Rep. Diane (D-Calif.) held a press conference on May 21 to announce the introduction of the Access, Compassion, Care, and Ethics for Seriously Ill Patients Act. The ACCESS Act seeks to increase terminally ill patients' access to promising treatments in the investigational phase of Food and Drug Administration (FDA) approval. I had the chance to interview one of the speakers at the press conference, Emil J. Freireich, M.D., the director of the Adult Leukemia Research Program at M.D. Cancer Center at The University of Texas. His opinions are quite provocative. " http://www.revolutionhealth.com/blogs/valjonesmd/are-fda-regulators-pr-13871 _________________________________ 2010 Aug 23;5(8). pii: e12300. Optimizing combination therapies with existing and future CML drugs. Abstract " Small-molecule inhibitors imatinib, dasatinib and nilotinib have been developed to treat Chromic Myeloid Leukemia (CML). The existence of a triple-cross-resistant mutation, T315I, has been a challenging problem, which can be overcome by finding new inhibitors. Many new compounds active against T315I mutants are now at different stages of development. In this paper we develop an algorithm which can weigh different combination treatment protocols according to their cross-resistance properties, and find the protocols with the highest probability of treatment success. This algorithm also takes into account drug toxicity by minimizing the number of drugs used, and their concentration. Although our methodology is based on a stochastic model of CML microevolution, the algorithm itself does not require measurements of any parameters (such as mutation rates, or division/death rates of cells), and can be used by medical professionals without a mathematical background. For illustration, we apply this algorithm to the mutation data obtained in.........(SORRY, this is short, but it after all an abstract and more will be released in journals later, but it is small window of what is developing or already developed.) http://www.ncbi.nlm.nih.gov/pubmed/20808800 FYI, Lottie Duthu Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 13, 2010 Report Share Posted September 13, 2010 Lottie - Thank you for including this information from Schorr, who I first in 1987 when he was a medical journalist doing a documentary for a national cable network. You're right, this is an older interview. He has more current information at his website http://www.patientpower.info/ and I reconnected after I was diagnosed with CML. I found helpful information on his PatientPower site, and then I found ! It was a wonderful reunion. He's in Seattle and I'm in Phoenix, and we got together this March with several people from the website I work for http://www.empowher.com/, and is now a contributor. He's a great person to have in your corner, and is truly dedicated to our best interests. He always welcomes hearing from patients about what's on our minds, and takes our concerns to the experts when he interviews them. On a personal level, he has been part of my support team for the past year, and his prayers and good wishes have helped keep me strong. Pat in Phoenix > > This is an older interview by Schorr, a CLL survivor himself, given by Dr. Talpaz and Dr. Giles. There is a webcast that you can download rather than read the interview. I read it and noted that AMN & BMS were in trials, but they referred to other therapies that targeted mutations were also in the pipes. I found it interesting and anyway, maybe some of you will, too, especially newcomers or those worried about what happens if Gleevec doesn't work for them, there are other drugs forthcoming. I have and perhaps some of you may have already read some of his other articles. > ( Schorr of Seattle is a medical journalist who was diagnosed with chronic lymphocytic leukemia in 1996. By participating in a clinical trial he has enjoyed a deep and lasting remission which has enabled him to be a pioneer in providing authoritative medical information online for other people facing serious illness. As a passionate patient-advocate, and with support from many of America's leading medical centers, has hosted and helped produce several thousand webcasts and videos for patients who have cancer or a wide range of chronic and acute medical concerns.) > > http://www.everydayhealth.com/cancer/webcasts/new-discoveries-in-cml-treatment-t\ ranscript-2.aspx > _____________________________________ > Quote Link to comment Share on other sites More sharing options...
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