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Open letter from Novartis

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Keeping you informed. This letter was published last month after the story

broke about the website not containing the risks of using Gleevec. This is to

set the record straight and the website has now been shut down.

August, 2010

Dear Patient or Caregiver:

Recently Novartis Pharmaceuticals Corporation received a Warning Letter from the

US Food and Drug Administration (FDA) stating that our www.cmlalliance.com

website contained misleading information about Gleevec because the website did

not contain any information about the serious risks of using Gleevec. As someone

registered to receive information from the program, this letter is being sent to

you at FDA’s request to provide important information about these serious risks

and to correct the messages and presentations that you may have seen on this

website about Gleevec that the FDA considered to be misleading.

Novartis takes the FDA Warning Letter very seriously and as a result has

suspended this website and all related materials. Novartis values the safety of

patients and believes that providing patients access to accurate, timely and

relevant disease information on rare diseases is important.

The entire letter can be read at this website:

http://www.cmlalliance.com/Aug-2010-Novartis-FDA-Ltr2CMLRev7.pdf

FYI,

Lottie Duthu

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