Tasigna no longer working poss bmt?

September 29, 2010

Where do I start. I've been a member of this group since diagnosis 5/2000. I've

had interferon and arac, moved onto the Gleevec trials, hit 0 twice, but didn't

last long. I was on that drug for 5 yrs. Then I moved to Sprycel trial, that

held me for 2.5 yrs, then quit working. Started Tasigna 1.5 years ago and now I

have had 3 consecutive increases in the pcr and my cyto results went up from 5%

to 25% in the last 3 months. I currently am at Greenebaum Cancer Ctr in Balt Md.

They do not have the Ariad drug as of yet, will be getting it, possibly late

October. I have had my Transplant Consult and am awaiting another next week at

Hopkins, trying to gather as much info as I can. My insurance just changed in

April of this year. In July, I just moved on to a full time position. (because I

have been feeling so good)! I'm not sure and no one can tell me how much time I

have until the disease progresses to next phase and transplant won't be an

option, they say. This new insurance is not allowing me the Clinical trial

option, says they won't pay at all. I'm not sold yet on the BMT, I have a

sibling 7/8 match. Last night got results of a mutation which follows. Does

anyone at all have any ideas, thoughts, advice? Just scheduled to visit Hershey

Medical Center and ins is also allowing Cleveland Clinic consult all for bmt

only.

* Final Report *

BCR-ABL1 kinase domain

Result: ? ? ? ?

A mutation was detected within the BCR-ABL1 kinase domain.

Nucleotide Change:

? ? ? ?

742 C>G

Predicted Amino Acid Change:

? ? ? ?

L248V

Interpretation:

Comment:

? ? ?

A nucleotide change encoding a leucine to valine substitution

at position 248 was detected within the BCR-ABL1 kinase

domain. The significance of this mutation in causing

resistance to imatinib mesylate is not known.

****************************************************************

Anxious for any input anyone may have!

Theresa Migut age 43

v

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