TKI's-could be future cures?????

[Guest guest]

Skip found this and I am referring it to you for your reading pleasure:

Tyrosine kinase inhibitor therapy can cure chronic myeloid leukemia without

hitting leukemic stem cells: http://www.cmlsupport.org.uk/node/6532

Gleevec pharmacology - courtesy of Dr. Druker and Novartis:

http://www.cmlsupport.org.uk/video (comes in 2 parts)

http://www.cmlsupport.org.uk/files/BLT_backgrounder_EUTOS.pdf

Treatment strategy for aggressive leukemias:

This is a quote from the article: " The work appears in Nature online on July 18.

Their findings implicate a protein called Mushashi that prevents cells from

maturing, creating a large population. "

http://www.cmlsupport.org.uk/node/6585

http://www.physorg.com/news198572075.html

FYI,

Lottie Duthu

of immature cells, which is one of the hallmarks of CML.