Intolerant to both Gleevec and Sprycel (cross post)

[Guest guest]

Hi,

I am a new member and have joined this group on behalf of my mother who lives in

Europe. She is 64 yrs. old and was diagnosed with CML in Nov 09. She was put on

Gleevec immediately after diagnosis and she very quickly went into remission.

Gleevec was doing an awesome job on the CML ,but as it turns out her liver was

not tolerating the drug. She was recently switched to Sprycel and now we just

found out that her liver does not tolerate this drug either. I cannot find any

information out there regarding intolerance to both drugs. Her doctors in Europe

are scratching their heads, as all of their patients with these types of liver

reactions have done well when switched to the other drug.

I am curious if anyone on this group has experience with multi drug intolerance.

Also, I live near s Hopkins Hospital in Baltimore and my mother is coming

for a visit in September. Anyone on this forum working with doctors there? Just

wondering if it might be worth a consultation, although my mom does feel that

she is in competent hands in Denmark.I can't help but hope that perhaps there is

a study or perhaps the experts at Hopkins are further ahead in their research.

I appreciate any input- as we can't bear to think that she might have run out of

options. Her doctors have told her that having a BMT at her age is very risky,

although she is extremely fit and healthy and active otherwise.

Thanks so much and I am looking forward to your insights!

Charlotte