Health matters

[Guest guest]

updated

_www.healthmatters.ws_ (http://www.healthmatters.ws)

[Guest guest]

We still don't know how we developed CML, but there are various chemicals that

are being blamed as carcinogens and formaldehyde gas is certainly in that class.

If you are interested, I have posted a portion of the article from Pub Med, the

rest you can read from the website. For health reasons, it is worth the long

read.

January 10, 2010........ " Formaldehyde (gas) is listed in the Eleventh Report on

Carcinogens (RoC) as reasonably anticipated to be a human carcinogen based on

limited evidence of carcinogenicity in humans and sufficient evidence of

carcinogenicity in laboratory animals (NTP 2005a); it was first listed in the

2nd RoC (NTP 1981). Formaldehyde (all physical forms) was nominated by NIEHS for

possible reclassification in the 12th RoC based on the 2004 review by the

International Agency for Research on Cancer (IARC 2006), which concluded that

there was sufficient evidence for the carcinogenicity of formaldehyde in humans.

Human Exposure: Formaldehyde has numerous industrial and commercial uses and is

produced in very large amounts (billions of pounds per year in the United

States) by CATALYTIC OXIDATION OF METHANOL.

" Formaldehyde gas is also created from the combustion of organic material and

can be produced secondarily in air from photochemical reactions involving

virtually all classes of hydrocarbon pollutants. In some instances, secondary

production may exceed direct air emissions. Formaldehyde is also produced

endogenously in humans and animals. Formaldehyde is a simple, one-carbon

molecule that is rapidly metabolized, is endogenously produced, and is also

formed through the metabolism of many xenobiotic agents. levels of formaldehyde

or its metabolites in blood or urine, have proven to be ineffective measures of

exposure. Formaldehyde can bind covalently to single-stranded DNA and protein to

form crosslinks, or with human serum albumin or the N-terminal valine of

hemoglobin to form molecular adducts, and these reaction products of

formaldehyde might serve as biomarkers for exposure to formaldehyde.

" Occupational exposure to formaldehyde is highly variable and can occur in

numerous industries, including the manufacture of formaldehyde and

formaldehyde-based resins, wood-composite and furniture production, plastics

production, histology and pathology, embalming and biology laboratories,

foundries, fiberglass production, construction, agriculture, and firefighting,

among others. In fact, because formaldehyde is ubiquitous, it has been suggested

that occupational exposure to formaldehyde occurs in all work places.

Formaldehyde is also ubiquitous in the environment and has been detected in

indoor and outdoor air; in treated drinking water, bottled drinking water,

surface water, and groundwater; on land and in the soil; and in numerous types

of food.

" The primary source of exposure is from inhalation of formaldehyde gas in indoor

settings (both residential and occupational); however, formaldehyde also may

adsorb to respirable particles, providing a source of additional exposure. Major

sources of formaldehyde exposure for the general public have included combustion

sources (both indoor and outdoor sources including industrial and automobile

emissions, home cooking and heating, and cigarette smoke), off-gassing from

numerous construction and home furnishing products, and off-gassing from

numerous consumer goods. Ingestion of food and water can also be a significant

source of exposure to formaldehyde.

" Numerous agencies, including the Department of Homeland Security, CPSC, DOT,

EPA, FDA, HUD, the Mine Safety and Health Administration, OSHA, ACGIH, and

NIOSH, have developed regulations and guidelines to reduce exposure to

formaldehyde. "

http://www.ncbi.nlm.nih.gov/pubmed/20737003

__________________________________

WHAT'S IN YOUR CAPSAICIN MAY SURPRISE YOU!

" Capsicum-derived ingredients function as skin-conditioning

agents--miscellaneous, external analgesics, flavoring agents, or fragrance

components in cosmetics. These ingredients are used in 19 cosmetic products at

concentrations as high as 5%.

" Cosmetic-grade material may be extracted using hexane, ethanol, or vegetable

oil and contain the full range of phytocompounds that are found in the Capsicum

annuum or Capsicum frutescens plant (aka red chiles), including Capsaicin.

Aflatoxin and N-nitroso compounds (N-nitrosodimethylamine and

N-nitrosopyrrolidine) have been detected as contaminants. The ultraviolet (UV)

absorption spectrum for Capsicum Annuum Fruit Extract indicates a small peak at

approximately 275 nm, and a gradual increase in absorbance, beginning at

approximately 400 nm.

" Capsicum and paprika are generally recognized as safe by the U.S. Food and Drug

Administration for use in food. Hexane, chloroform, and ethyl acetate extracts

of Capsicum Frutescens Fruit at 200 mg/kg resulted in death of all mice. In a

short-term inhalation toxicity study using rats, no difference was found between

vehicle control and a 7% Capsicum Oleoresin solution. In a 4-week feeding study,

red chilli (Capsicum annuum) in the diet at concentrations up to 10% was

relatively nontoxic in groups of male mice. In an 8-week feeding study using

rats, intestinal exfoliation, cytoplasmic fatty vacuolation and centrilobular

necrosis of hepatocytes, and aggregation of lymphocytes in the portal areas were

seen at 10% Capsicum Frutescens Fruit, but not 2%. Rats fed 0.5 g/kg day-1 crude

Capsicum Fruit Extract for 60 days exhibited no significant gross pathology at

necropsy, but slight hyperemia of the liver and reddening of the gastric mucosa

were observed. Weanling rats fed basal diets supplemented with whole red pepper

at concentrations up to 5.0% for up to 8 weeks had no pathology of the large

intestines, livers, and kidneys, but destruction of the taste buds and

keratinization and erosion of the gastrointestinal (GI) tract were noted in

groups fed 0.5% to 5.0% red pepper. The results of 9-and 12-month extension of

this study showed normal large intestines and kidneys. In rabbits fed Capsicum

Annuum Powder at 5 mg/kg day-1 in the diet daily for 12 months damage to the

liver and spleen was noted. A rabbit skin irritation test of Capsicum Annuum

Fruit Extract at concentrations ranging from 0.1% to 1.0% produced no

irritation, but Capsicum Frutescens Fruit Extract induced

concentration-dependent (at 25 to 500 microg/ml) cytotoxicity in a human buccal

mucosa fibroblast cell line. An ethanol extract of red chili was mutagenic in

Salmonella typhimurium TA98, but not in TA100, or in Escherichia coli. " More at

website.

http://www.ncbi.nlm.nih.gov/pubmed/17365137

________________________

FYI,

Lottie Duthu

[Guest guest]

I would like to know about geopathic stress as it has come up a lot recently.

Has anyone delved into this possible cause?

Luv UK Beth

From: Lottie Duthu <lotajam@...>

Subject: [ ] Health matters

" CML " < >

Date: Tuesday, 5 October, 2010, 8:01

 

We still don't know how we developed CML, but there are various chemicals

that are being blamed as carcinogens and formaldehyde gas is certainly in that

class. If you are interested, I have posted a portion of the article from Pub

Med, the rest you can read from the website. For health reasons, it is worth

the long read.

January 10, 2010........ " Formaldehyde (gas) is listed in the Eleventh Report on

Carcinogens (RoC) as reasonably anticipated to be a human carcinogen based on

limited evidence of carcinogenicity in humans and sufficient evidence of

carcinogenicity in laboratory animals (NTP 2005a); it was first listed in the

2nd RoC (NTP 1981). Formaldehyde (all physical forms) was nominated by NIEHS for

possible reclassification in the 12th RoC based on the 2004 review by the

International Agency for Research on Cancer (IARC 2006), which concluded that

there was sufficient evidence for the carcinogenicity of formaldehyde in humans.

Human Exposure: Formaldehyde has numerous industrial and commercial uses and is

produced in very large amounts (billions of pounds per year in the United

States) by CATALYTIC OXIDATION OF METHANOL.

" Formaldehyde gas is also created from the combustion of organic material and

can be produced secondarily in air from photochemical reactions involving

virtually all classes of hydrocarbon pollutants. In some instances, secondary

production may exceed direct air emissions. Formaldehyde is also produced

endogenously in humans and animals. Formaldehyde is a simple, one-carbon

molecule that is rapidly metabolized, is endogenously produced, and is also

formed through the metabolism of many xenobiotic agents. levels of formaldehyde

or its metabolites in blood or urine, have proven to be ineffective measures of

exposure. Formaldehyde can bind covalently to single-stranded DNA and protein to

form crosslinks, or with human serum albumin or the N-terminal valine of

hemoglobin to form molecular adducts, and these reaction products of

formaldehyde might serve as biomarkers for exposure to formaldehyde.

" Occupational exposure to formaldehyde is highly variable and can occur in

numerous industries, including the manufacture of formaldehyde and

formaldehyde-based resins, wood-composite and furniture production, plastics

production, histology and pathology, embalming and biology laboratories,

foundries, fiberglass production, construction, agriculture, and firefighting,

among others. In fact, because formaldehyde is ubiquitous, it has been suggested

that occupational exposure to formaldehyde occurs in all work places.

Formaldehyde is also ubiquitous in the environment and has been detected in

indoor and outdoor air; in treated drinking water, bottled drinking water,

surface water, and groundwater; on land and in the soil; and in numerous types

of food.

" The primary source of exposure is from inhalation of formaldehyde gas in indoor

settings (both residential and occupational); however, formaldehyde also may

adsorb to respirable particles, providing a source of additional exposure. Major

sources of formaldehyde exposure for the general public have included combustion

sources (both indoor and outdoor sources including industrial and automobile

emissions, home cooking and heating, and cigarette smoke), off-gassing from

numerous construction and home furnishing products, and off-gassing from

numerous consumer goods. Ingestion of food and water can also be a significant

source of exposure to formaldehyde.

" Numerous agencies, including the Department of Homeland Security, CPSC, DOT,

EPA, FDA, HUD, the Mine Safety and Health Administration, OSHA, ACGIH, and

NIOSH, have developed regulations and guidelines to reduce exposure to

formaldehyde. "

http://www.ncbi.nlm.nih.gov/pubmed/20737003

__________________________________

WHAT'S IN YOUR CAPSAICIN MAY SURPRISE YOU!

" Capsicum-derived ingredients function as skin-conditioning

agents--miscellaneous, external analgesics, flavoring agents, or fragrance

components in cosmetics. These ingredients are used in 19 cosmetic products at

concentrations as high as 5%.

" Cosmetic-grade material may be extracted using hexane, ethanol, or vegetable

oil and contain the full range of phytocompounds that are found in the Capsicum

annuum or Capsicum frutescens plant (aka red chiles), including Capsaicin.

Aflatoxin and N-nitroso compounds (N-nitrosodimethylamine and

N-nitrosopyrrolidine) have been detected as contaminants. The ultraviolet (UV)

absorption spectrum for Capsicum Annuum Fruit Extract indicates a small peak at

approximately 275 nm, and a gradual increase in absorbance, beginning at

approximately 400 nm.

" Capsicum and paprika are generally recognized as safe by the U.S. Food and Drug

Administration for use in food. Hexane, chloroform, and ethyl acetate extracts

of Capsicum Frutescens Fruit at 200 mg/kg resulted in death of all mice. In a

short-term inhalation toxicity study using rats, no difference was found between

vehicle control and a 7% Capsicum Oleoresin solution. In a 4-week feeding study,

red chilli (Capsicum annuum) in the diet at concentrations up to 10% was

relatively nontoxic in groups of male mice. In an 8-week feeding study using

rats, intestinal exfoliation, cytoplasmic fatty vacuolation and centrilobular

necrosis of hepatocytes, and aggregation of lymphocytes in the portal areas were

seen at 10% Capsicum Frutescens Fruit, but not 2%. Rats fed 0.5 g/kg day-1 crude

Capsicum Fruit Extract for 60 days exhibited no significant gross pathology at

necropsy, but slight hyperemia of the liver and reddening of the gastric mucosa

were observed.

Weanling rats fed basal diets supplemented with whole red pepper at

concentrations up to 5.0% for up to 8 weeks had no pathology of the large

intestines, livers, and kidneys, but destruction of the taste buds and

keratinization and erosion of the gastrointestinal (GI) tract were noted in

groups fed 0.5% to 5.0% red pepper. The results of 9-and 12-month extension of

this study showed normal large intestines and kidneys. In rabbits fed Capsicum

Annuum Powder at 5 mg/kg day-1 in the diet daily for 12 months damage to the

liver and spleen was noted. A rabbit skin irritation test of Capsicum Annuum

Fruit Extract at concentrations ranging from 0.1% to 1.0% produced no

irritation, but Capsicum Frutescens Fruit Extract induced

concentration-dependent (at 25 to 500 microg/ml) cytotoxicity in a human buccal

mucosa fibroblast cell line. An ethanol extract of red chili was mutagenic in

Salmonella typhimurium TA98, but not in TA100, or in Escherichia coli. " More at

website.

http://www.ncbi.nlm.nih.gov/pubmed/17365137

________________________

FYI,

Lottie Duthu