Glucosomine - Something to Think About - How Much is Too Much????

[Guest guest]

" High doses or prolonged use of glucosamine causes the death of pancreatic cells

and could increase the risk of developing diabetes, according to a team of

researchers at Université Laval's Faculty of Pharmacy. Details of this discovery

were recently published on the website of the Journal of Endocrinology.

" In vitro tests conducted by Professor Frédéric Picard and his team revealed

that glucosamine exposure causes a significant increase in mortality in

insulin-producing pancreatic cells, a phenomenon tied to the development of

diabetes. Cell death rate increases with glucosamine dose and exposure time. " In

our experiments, we used doses five to ten times higher than that recommended by

most manufacturers, or 1,500 mg/day, " stressed Professor Picard. " Previous

studies showed that a significant proportion of glucosamine users up the dose

hoping to increase the effects, " he explained.

" Picard and his team have shown that glucosamine triggers a mechanism intended

to lower very high blood sugar levels. However, this reaction negatively affects

SIRT1, a protein critical to cell survival. A high concentration of glucosamine

diminishes the level of SIRT1, leading to cell death in the tissues where this

protein is abundant, such as the pancreas. Individuals who use large amounts of

glucosamine, those who consume it for long periods, and those with little SIRT1

in their cells are therefore believed to be at greater risk of developing

diabetes. In a number of mammal species, SIRT1 level diminishes with age. This

phenomenon has not been shown in humans but if it were the case, the elderly -

who constitute the target market for glucosamine - would be even more

vulnerable. "

http://www.medicalnewstoday.com/articles/206049.php

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FY,

Lottie Duthu