Cardiac News from an unlikely place

[Guest guest]

" Researchers in Newfoundland have cracked the genetic code of a sudden death

cardiac killer. As a result, they have developed a unique prevention program in

which people with no symptoms, but with a suspect gene and a family history, are

being implanted with internal cardiac defibrillators (ICDs) which can restart

their hearts if they stop.

" Our discovery has led to a targeted genetic screening and individualized

therapy that is significantly improving survival rates, " Dr. Connors told

the Canadian Cardiovascular Congress 2010, co-hosted by the Heart and Stroke

Foundation and the Canadian Cardiovascular Society. " It's allowing people with

the condition to live normal, longer lives. Individualized genetic therapies

like this are the future of medicine. "

Genetic profiling?

The surest sign that a disease is genetic in origin is when it is manifests

itself in family histories, showing up in generation after generation.

" Our diagnostic testing showed that some members of these families have a

specific, genetic, electrocardiogram (ECG) mutation - ARVD5, " said Dr. Connors.

There is a 50 per cent chance that children of those with the condition will

also be carriers of the gene. It is considered the second-most common cause of

sudden cardiac death in young people. The mutation causes premature sudden

cardiac death in males: 50 per cent die by age 40 years and 80 per cent by 50

years. "

Source:

Jane-Diane Fraser Heart and Stroke Foundation of Canada

http://www.medicalnewstoday.com/articles/205956.php

=======================

FYI,

Lottie Duthu

[Guest guest]

Hi, Folks,

Had cardiac cath Friday and heart disease has not progressed since heart attack

five years ago.

Cholesterol is 135 and has been low since starting Gleevec eight years ago and

changing to Sprycel two years ago.

My MSKCC doc says Gleevec may suppress cholesterol, in turn reducing heart

disease risk.

Have any of your docs mentioned this or have you seen any reports that Gleevec

and/or other TKI's may lower cholesterol??

Hang in,

Carl

________________________________

From: Lottie Duthu <lotajam@...>

CML < >

Sent: Thu, November 4, 2010 1:24:06 PM

Subject: [ ] Cardiac News from an unlikely place

" Researchers in Newfoundland have cracked the genetic code of a sudden death

cardiac killer. As a result, they have developed a unique prevention program in

which people with no symptoms, but with a suspect gene and a family history, are

being implanted with internal cardiac defibrillators (ICDs) which can restart

their hearts if they stop.

" Our discovery has led to a targeted genetic screening and individualized

therapy that is significantly improving survival rates, " Dr. Connors told

the Canadian Cardiovascular Congress 2010, co-hosted by the Heart and Stroke

Foundation and the Canadian Cardiovascular Society. " It's allowing people with

the condition to live normal, longer lives. Individualized genetic therapies

like this are the future of medicine. "

Genetic profiling?

The surest sign that a disease is genetic in origin is when it is manifests

itself in family histories, showing up in generation after generation.

" Our diagnostic testing showed that some members of these families have a

specific, genetic, electrocardiogram (ECG) mutation - ARVD5, " said Dr. Connors.

There is a 50 per cent chance that children of those with the condition will

also be carriers of the gene. It is considered the second-most common cause of

sudden cardiac death in young people. The mutation causes premature sudden

cardiac death in males: 50 per cent die by age 40 years and 80 per cent by 50

years. "

Source:

Jane-Diane Fraser Heart and Stroke Foundation of Canada

http://www.medicalnewstoday.com/articles/205956.php

=======================

FYI,

Lottie Duthu

[Guest guest]

Yes. I had brought up to the group that my mother who has been on gleevec for

approx 5 months had a physical and her cholesterol levels were amazing! They

were all within normal range. My mom's cholesterol numbers were always

horrible and so we even questioned if the lab could of had someone else's

numbers LOL. So then I asked the group if anyone else had this response. It's

very interesting to me because Im a cardiac nurse. One of the group members

sent me to a site where they are currently doing research on gleevec helping

with atherosclerosis.

I gave a copy of the info to one of the cardiologist I work with.

Karine

On Sat Nov 6th, 2010 10:02 AM EDT Carl Davies wrote:

>Hi, Folks,

>Had cardiac cath Friday and heart disease has not progressed since heart attack

>five years ago.

>

>Cholesterol is 135 and has been low since starting Gleevec eight years ago and

>changing to Sprycel two years ago.

>

>My MSKCC doc says Gleevec may suppress cholesterol, in turn reducing heart

>disease risk.

>

>Have any of your docs mentioned this or have you seen any reports that Gleevec

>and/or other TKI's may lower cholesterol??

> Hang in,

>Carl

>

>

>

>

>

>

>________________________________

>From: Lottie Duthu <lotajam@...>

>CML < >

>Sent: Thu, November 4, 2010 1:24:06 PM

>Subject: [ ] Cardiac News from an unlikely place

>

>

> " Researchers in Newfoundland have cracked the genetic code of a sudden death

>cardiac killer. As a result, they have developed a unique prevention program in

>which people with no symptoms, but with a suspect gene and a family history,

are

>being implanted with internal cardiac defibrillators (ICDs) which can restart

>their hearts if they stop.

>

>

> " Our discovery has led to a targeted genetic screening and individualized

>therapy that is significantly improving survival rates, " Dr. Connors told

>the Canadian Cardiovascular Congress 2010, co-hosted by the Heart and Stroke

>Foundation and the Canadian Cardiovascular Society. " It's allowing people with

>the condition to live normal, longer lives. Individualized genetic therapies

>like this are the future of medicine. "

>

>

>Genetic profiling?

>

>The surest sign that a disease is genetic in origin is when it is manifests

>itself in family histories, showing up in generation after generation.

>

>

> " Our diagnostic testing showed that some members of these families have a

>specific, genetic, electrocardiogram (ECG) mutation - ARVD5, " said Dr. Connors.

>There is a 50 per cent chance that children of those with the condition will

>also be carriers of the gene. It is considered the second-most common cause of

>sudden cardiac death in young people. The mutation causes premature sudden

>cardiac death in males: 50 per cent die by age 40 years and 80 per cent by 50

>years. "

>

>Source:

>Jane-Diane Fraser Heart and Stroke Foundation of Canada

>

>http://www.medicalnewstoday.com/articles/205956.php

>=======================

>FYI,

>Lottie Duthu

>

>

[Guest guest]

Thanks, Karine. My cholesterol remains low on Sprycel, so I was wondering there

is any literature on this, or if anyone on Sprycel has discussed this with

his/her doc.

Best,

Carl

________________________________

From: Karine Vallier <karinevallier@...>

Sent: Sat, November 6, 2010 8:06:17 PM

Subject: Re: [ ] Cardiac News from an unlikely place

Yes. I had brought up to the group that my mother who has been on gleevec for

approx 5 months had a physical and her cholesterol levels were amazing! They

were all within normal range. My mom's cholesterol numbers were always

horrible and so we even questioned if the lab could of had someone else's

numbers LOL. So then I asked the group if anyone else had this response. It's

very interesting to me because Im a cardiac nurse. One of the group members

sent me to a site where they are currently doing research on gleevec helping

with atherosclerosis.

I gave a copy of the info to one of the cardiologist I work with.

Karine

On Sat Nov 6th, 2010 10:02 AM EDT Carl Davies wrote:

>Hi, Folks,

>Had cardiac cath Friday and heart disease has not progressed since heart attack

>five years ago.

>

>Cholesterol is 135 and has been low since starting Gleevec eight years ago and

>changing to Sprycel two years ago.

>

>My MSKCC doc says Gleevec may suppress cholesterol, in turn reducing heart

>disease risk.

>

>Have any of your docs mentioned this or have you seen any reports that Gleevec

>and/or other TKI's may lower cholesterol??

> Hang in,

>Carl

>

>

>

>

>

>

>________________________________

>From: Lottie Duthu <lotajam@...>

>CML < >

>Sent: Thu, November 4, 2010 1:24:06 PM

>Subject: [ ] Cardiac News from an unlikely place

>

>

> " Researchers in Newfoundland have cracked the genetic code of a sudden death

>cardiac killer. As a result, they have developed a unique prevention program in

>which people with no symptoms, but with a suspect gene and a family history,

are

>

>being implanted with internal cardiac defibrillators (ICDs) which can restart

>their hearts if they stop.

>

>

> " Our discovery has led to a targeted genetic screening and individualized

>therapy that is significantly improving survival rates, " Dr. Connors told

>the Canadian Cardiovascular Congress 2010, co-hosted by the Heart and Stroke

>Foundation and the Canadian Cardiovascular Society. " It's allowing people with

>the condition to live normal, longer lives. Individualized genetic therapies

>like this are the future of medicine. "

>

>

>Genetic profiling?

>

>The surest sign that a disease is genetic in origin is when it is manifests

>itself in family histories, showing up in generation after generation.

>

>

> " Our diagnostic testing showed that some members of these families have a

>specific, genetic, electrocardiogram (ECG) mutation - ARVD5, " said Dr. Connors.

>There is a 50 per cent chance that children of those with the condition will

>also be carriers of the gene. It is considered the second-most common cause of

>sudden cardiac death in young people. The mutation causes premature sudden

>cardiac death in males: 50 per cent die by age 40 years and 80 per cent by 50

>years. "

>

>Source:

>Jane-Diane Fraser Heart and Stroke Foundation of Canada

>

>http://www.medicalnewstoday.com/articles/205956.php

>=======================

>FYI,

>Lottie Duthu

>

>